Mastite lactacional grave: particularidades da internação à alta

RESUMO Objetivo: identificar as características de mulheres que sofreram mastite lactacional grave. Método: estudo descritivo, retrospectivo e documental, com abordagem quantitativa. Os dados foram coletados de registros da assistência nos prontuários de 114 mulheres internadas no período de janeiro de 2009 a dezembro de 2013. Análise mediante estatística descritiva. Resultados: constatou-se maior porcentagem de mastite lactacional grave em mulheres jovens, primíparas, com ensino médio completo, que não tinham companheiro e não trabalhavam fora do lar; 96,5% das mulheres tiveram alguma intercorrência mamária antes da internação e permaneceram internadas em média 4,4 dias; na alta hospitalar 23,7% das mulheres desmamaram. Conclusão: este estudo mostrou que a mastite lactacional grave pode causar grandes danos à mulher e ao bebê

Neuronal Nitric Oxide Synthase (NOS1) Polymorphisms Interact with Financial Hardship to Affect Depression Risk.

There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genotyped. Significant associations between eight NOS1 SNPs, comprising two regional haplotypes, and current depression score were identified that survived correction for multiple testing when current financial hardship was used as the interaction term. A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p=2.3E-05). These results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual's susceptibility to depression.Neuropsychopharmacology advance online publication, 16 July 2014; doi:10.1038/npp.2014.137