Free volume, molecular grains, self-organisation, and anisotropic entropy : machining materials

In this article, the relationship between molecular architecture and the formation of twist-bend phases is reviewed under the context of shape dependency. We conclude that the twist-bend phase is a universal phenomenon, which occurs in a wide variety of materials, for dimers through to main chain polymers. In the process, the chemical information on molecular design is effectively lost or irrelevant, and molecular topology takes precedence over electrostatic interactions in mesophase formation. As a consequence of this macro-scale material, engineering by shape alone becomes a possibility, potentially more phases may be realised, and entropy is anisotropic

Las masculinidades de los hombres homosexuales en Plata quemada, de Ricardo Piglia

El artículo propone un análisis de la novela Plata quemada (1997) de RicardoPiglia desde los postulados de los Estudios de varones y masculinidades. Apartir de estos, se revisa la función que cumple el imaginario en torno al rol degénero masculino, específicamente en lo que concierne al origen y desarrollo de la violencia. También se examina la influencia del falogocentrismo en el hombre homosexual y la influencia de la mujer en la construcción y disputa de los roles de género en estos individuos. El objetivo central es ver la manera en que la cultura patriarcal y heterosexista está presente en el varón homosexual como en el resto de la sociedad, proyectándose tanto en su visión del mundo como en sus dinámicas de comportamiento, y también como un factor coercitivo en su relación con los individuos y colectivos que lo circundan

The role of T-cell protein tyrosine phosphatase in epithelial carcinogenesis

T-cell protein tyrosine phosphatase (TC-PTP, encoded by PTPN2) is a non-receptor PTP that is mostly highly expressed in hematopoietic tissues. TC-PTP modulates a variety of physiological functions including cell cycle progression, cell survival and proliferation, and hematopoiesis through tyrosine dephosphorylation of its target substrates, such as EGFR, JAK1, JAK3, STAT1, and STAT3. Studies with whole or tissue-specific loss of TC-PTP function transgenic mice have shown that TC-PTP has crucial roles in the regulation of the immune response, insulin signaling, and oncogenic signaling. More recently, generation of epidermal-specific TC-PTP-deficient mice for use in multistage skin carcinogenesis bioassays demonstrated that TC-PTP suppresses skin tumor formation by negatively regulating STAT3 and AKT signaling. Further investigation showed that TC-PTP also minimizes UVB-induced epidermal cell damage by promoting apoptosis through the negative regulation of Flk-1/JNK signaling. These findings provide major evidence for a tumor suppressive function for TC-PTP against environment-induced skin cancer. Here, we will discuss TC-PTP, its substrates, and its functions with an emphasis on its role in skin carcinogenesis

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2 p. ; 24 cm

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Understanding the twist-bend nematic phase: the characterisation of 1-(4-cyanobiphenyl-4'-yloxy)-6-(4-cyanobiphenyl-4'-yl) hexane (CB6OCB) and comparison with CB7CB

Acknowledgements The FFTEM data were obtained at the (Cryo) TEM facility at the Liquid Crystal Institute, Kent State University, supported by the Ohio Research Scholars Program Research Cluster on Surfaces in Advanced Materials. ODL acknowledges the support of NSF DMR-1410378 grant. The authors are grateful for financial support from MINECO/FEDER MAT2015-66208-C3-2-P and from the Gobierno Vasco (GI/IT-449-10) OA via RSC Gold4GoldPeer reviewedPublisher PD

Allelic polymorphism in the T cell receptor and its impact on immune responses

In comparison to human leukocyte antigen (HLA) polymorphism, the impact of allelic sequence variation within T cell receptor (TCR) loci is much less understood. Particular TCR loci have been associated with autoimmunity, but the molecular basis for this phenomenon is undefined. We examined the T cell response to an HLA-B*3501-restricted epitope (HPVGEADYFEY) from Epstein-Barr virus (EBV), which is frequently dominated by a TRBV9*01 public TCR (TK3). However, the common allelic variant TRBV9*02, which differs by a single amino acid near the CDR2β loop (Gln55→His55), was never used in this response. The structure of the TK3 TCR, its allelic variant, and a nonnaturally occurring mutant (Gln55→Ala55) in complex with HLA-B*3501 revealed that the Gln55→His55 polymorphism affected the charge complementarity at the TCR-peptide-MHC interface, resulting in reduced functional recognition of the cognate and naturally occurring variants of this EBV peptide. Thus, polymorphism in the TCR loci may contribute toward variability in immune responses and the outcome of infection

Injury patterns in U15 rugby players in Ulster Schools: A Rugby Injury Surveillance (RISUS) study

Participation in collision sports such as rugby union has inherent risk of injury. The aim of this study was to examine injury patterns and risk factors in adolescent rugby players (U15 years). A prospective injury surveillance study was undertaken involving 26 schools (599 male rugby players, mean age 14.7years). Data were collected over the 2016/17 playing season, with injuries classified by body part and diagnosis. We explored the association between risk factors (demographic/biometric; injury history, protective equipment, training profile, level of play) using cox proportional hazard models with time to injury as the dependent variable. Nearly, 30% of players (178/599) suffered at least one injury. Injury incidence is estimated at 14.7 injuries/1000 match hours. Most injuries occurred in the tackle situation (64.6%, 135/209). Common injury sites were head/face (n = 95, 45.5%), ankle (n = 21, 10.0%), or wrist/hand (n = 15, 7.2%). Concussion (n = 79, 37.8%), wrist/ hand fractures (n = 19, 9.1%), or ankle sprains (n = 16, 7.6%) were the most common diagnoses. Seven concussions (8.9%) resulted in more than 28 days absence from play. A higher risk of injury was associated with: previous concussion (AHR 1.45; 95% CI 1.02 to 2.06), and any previous injury (AHR 1.85; 95% CI 1.23 to 2.78). One in three U15 rugby players sustained an injury over a single playing season. Concussion remains a concern in this age group and should be prioritized in future research

Implementing physically active learning: Future directions for research, policy, and practice

Objective Identify co-produced multi-stakeholder perspectives important for successful widespread physically active learning (PAL) adoption and implementation. Method A total of 35 stakeholders (policy makers, n = 9; commercial education sector, n = 8; teachers, n = 3; researchers, n = 15) attended a design thinking PAL workshop. Participants formed 5 multi-disciplinary groups with at least 1 representative from each stakeholder group. Each group, facilitated by a researcher, undertook 2 tasks: (1) using Post-it Notes, the following question was answered: within the school day, what are the opportunities for learning combined with movement? and (2) structured as a washing-line task, the following question was answered: how can we establish PAL as the norm? All discussions were audio-recorded and transcribed. Inductive analyses were conducted by 4 authors. After the analyses were complete, the main themes and subthemes were assigned to 4 predetermined categories: (1) PAL design and implementation, (2) priorities for practice, (3) priorities for policy, and (4) priorities for research. Results The following were the main themes for PAL implementation: opportunities for PAL within the school day, delivery environments, learning approaches, and the intensity of PAL. The main themes for the priorities for practice included teacher confidence and competence, resources to support delivery, and community of practice. The main themes for the policy for priorities included self-governance, the Office for Standards in Education, Children's Services and Skill, policy investment in initial teacher training, and curriculum reform. The main themes for the research priorities included establishing a strong evidence base, school-based PAL implementation, and a whole-systems approach. Conclusion The present study is the first to identify PAL implementation factors using a combined multi-stakeholder perspective. To achieve wider PAL adoption and implementation, future interventions should be evidence based and address implementation factors at the classroom level (e.g., approaches and delivery environments), school level (e.g., communities of practice), and policy level (e.g., initial teacher training)