Simulation and measurement of hts josephson heterodyne oscillator

We report continuing investigations into practical applications of the ac Josephson effect as the basis for a voltage-tunable radio-frequency oscillator. We have previously demonstrated experimentally that useful power levels (10 s of nW) and linewidths of a few kHz can be achieved in the heterodyne output from a High-Temperature-Superconducting Resistive SQUID (HTS-RSQUID) operating in the frequency range 1-50 MHz. Those results were achieved with 2-junction R-SQUIDs incorporating current-biased shunt resistors of a few micro-ohms. We have now modified the fabrication procedures, and adjusted the shunt resistors and bias current values so that higher frequencies can be achieved. The Josephson junctions are of step-edge type, rather than the bi-crystal type used in our earlier work. The step-edge technique permits much more flexibility in the geometrical lay-out and utilizes the more cost-effective single-crystal MgO substrates. In the present paper, we report numerical simulations and experimental measurements on these devices in the frequency range up to 2 GHz

'Learning together': Sharing international experience on new models of primary care

No abstract available

Evidence that process simulations reduce anxiety in patients receiving dental treatment: randomized exploratory trial

Process simulations – mental simulations that ask people to imagine the process of completing a task – have been shown to decrease anxiety in students facing hypothetical or psychological threats in the short term. The aim of the present study was to see whether process simulations could reduce anxiety in a sample of the general population attending a dental practice, and whether these effects could be sustained throughout treatment. Participants (N = 75) were randomized to an experimental condition where they were asked to simulate mentally the process of seeing the dentist, or to a control condition where they were asked to simulate mentally the outcome of seeing the dentist. Findings showed that participants in the experimental condition were significantly less anxious both before and after their consultations. Self-efficacy and self-esteem remained unchanged. This study suggests that process simulation is one active ingredient in anxiety treatment programs and further research is required to enhance its effects

Integrated Ocean Drilling Program Expedition 317/319 Scientific Prospectus: Pacific Equatorial Age Transect

As the world's largest ocean, the Pacific is intricately linked to major changes in the global climate system. Throughout the Cenozoic, Pacific plate motion has had a northward component. Thus, the Pacific is unique in that the thick sediment bulge of biogenic-rich deposits from the currently narrowly focused zone of equatorial upwelling is slowly moving away from the Equator. Hence, older sections are not deeply buried and can be recovered by drilling. Previous drilling in this area during Ocean Drilling Program (ODP) Legs 138 and 199 was remarkably successful in giving us new insights into the workings of the climate and carbon system, productivity changes across the zone of divergence, time-dependent calcium carbonate dissolution, bio- and magnetostratigraphy, the location of the Intertropical Convergence Zone (ITCZ), and evolutionary patterns for times of climatic change and upheaval. Together with older Deep Sea Drilling Project drilling in the eastern equatorial Pacific, both legs also helped to delineate the position of the paleoequator and variations in sediment thickness from ~150°W to 110°W.The Pacific equatorial age transect (PEAT) science program is based on Integrated Ocean Drilling Program (IODP) Proposal 626 and consists of Expeditions 317 and 319, grouped into one science program. The goal is to recover a continuous Cenozoic record of the equatorial Pacific by drilling at the paleoposition of the Equator at successive crustal ages on the Pacific plate. Records collected from Expeditions 317 and 319 are to be joined with records of previous drilling during ODP Legs 138 and 199 to make a complete equatorial Pacific record from 0 to 55 Ma. Previously, ODP Legs 138 and 199 were designed as transects across the paleoequator in order to study the changing patterns of sediment deposition across equatorial regions at critical time intervals. As we have gained more information about the past movement of plates and when in Earth's history "critical" climate events took place, it becomes possible to drill an age transect ("flow-line") along the position of the Pacific paleoequator. The goal of this transect is to target important time slices where calcareous sediments have been best preserved and the sedimentary archive will allow us to reconstruct past climatic and tectonic conditions. Leg 199 enhanced our understanding of extreme changes of the calcium carbonate compensation depth (CCD) across major geological boundaries during the last 55 m.y. A very shallow CCD during most of the Paleogene makes it difficult to obtain well-preserved sediments during these stratigraphic intervals, but the strategy of site locations for the current two expeditions is designed to occupy the most promising sites and to obtain a unique sedimentary biogenic sediment archive for time periods just after the Paleocene/Eocene boundary event, Eocene cooling, the Eocene–Oligocene transition, the "one cold pole" Oligocene, the Oligocene–Miocene transition, and the Miocene. These new cores and data will significantly contribute to the objectives of the IODP Extreme Climates Initiative and will provide material that the previous legs were not able to recover.For logistical reasons, the PEAT science program is composed of two expeditions but is being implemented as a single science program to best achieve the overall objectives of Proposal 626. Participants on both expeditions (as well as approved shore-based scientists) will comprise a single science party with equal access to data and materials from both cruises. Sampling aboard the ship will be minimal, and the bulk of the sampling will be completed postcruise.The operational plan is to occupy eight sites along the age transect with the goal of recovering as complete a sedimentary succession as possible. This will probably require three holes to be cored at each site with wireline logging operations in one hole. Basement will be tagged in at least one of the holes. Expedition 317 will be directed primarily to sample the Neogene sites (proposed Sites PEAT-2C, 6C, and 7C, in priority order). The second expedition (319) will primarily sample the Paleogene sites (proposed Sites PEAT-1C, 3C, 4C, and possibly 5C, in priority order)

Reliability of Hallux Rigidus Radiographic Grading System

Introduction. The purpose of this study was to determine the inter- and intra-observer reliability of a clinical radiographic scale for hallux rigidus. Methods. A total of 80 patients were retrospectively selected from the patient population of two foot and ankle orthopaedic surgeons. Each corresponding series of radiographic images (weight-bearing anteroposterior, weight-bearing lateral, and oblique of the foot) was randomized and evaluated. Re-randomization was performed and the corresponding radiograph images re-numbered. Four orthopaedic foot and ankle surgeons graded each patient, and each rater reclassified the re-randomized radiographic images three weeks later. Results. Sixty-one out of 80 patients (76%) were included in this study. For intra-observer reliability, most of the raters showed “excellent” agreement except one rater had a “substantial” agreement. For inter-observer reliability, only 14 out of 61 cases (23%) showed total agreement between the eight readings from the four surgeons, and 11 out of the 14 cases (79%) were grade 3 hallux rigidus. One of the raters had a tendency to grade at a higher grade resulting in poorer agreement. If this rater was excluded, the results demonstrated a “substantial” agreement by using this classification. Conclusion. The hallux rigidus radiographic grading system should be used with caution. Although there is an “excellent” level of intra-observer agreement, there is only “moderate” to “substantial” level of inter-observer reliability

P09-15. Selection of higher avidity HLA-restricted T cell responses as a viral adaptation strategy

Loss of immune reactivity due to HIV mutational escape is well described. Data generated from a large population-based study (n>800) suggested that certain CD8 T cell epitopes are created as a result of HIV adaptation and are associated with enhanced viral replication. Here we sought to investigate the HLA-restricted T-cell responses associated with seven such adaptations

Coherent States and Modified de Broglie-Bohm Complex Quantum Trajectories

This paper examines the nature of classical correspondence in the case of coherent states at the level of quantum trajectories. We first show that for a harmonic oscillator, the coherent state complex quantum trajectories and the complex classical trajectories are identical to each other. This congruence in the complex plane, not restricted to high quantum numbers alone, illustrates that the harmonic oscillator in a coherent state executes classical motion. The quantum trajectories are those conceived in a modified de Broglie-Bohm scheme and we note that identical classical and quantum trajectories for coherent states are obtained only in the present approach. The study is extended to Gazeau-Klauder and SUSY quantum mechanics-based coherent states of a particle in an infinite potential well and that in a symmetric Poschl-Teller (PT) potential by solving for the trajectories numerically. For the coherent state of the infinite potential well, almost identical classical and quantum trajectories are obtained whereas for the PT potential, though classical trajectories are not regained, a periodic motion results as t --> \infty.Comment: More example

Cumulative impact assessment of tidal stream energy extraction in the Irish Sea

A cumulative impact assessment of tidal stream developments in the Irish Sea has been conducted on a high-resolution depth-averaged hydrodynamic model, using Telemac2D. Eight sites were investigated, representing the proposed developments at the time of study. These included: Ramsey Sound, Anglesey, Strangford Loch, Mull of Kintyre, Torr Head, Fair Head, Sound of Islay and West of Islay. Only three projects showed array-array interaction: Fair Head, Torr Head and Mull of Kintyre. A smaller model domain was created for further analysis. Results showed Mull of Kintyre had little impact. Fair Head reduced the energy production at Torr Head by 17%, whereas, Fair Head only reduced by 2%. This was caused by the tidal asymmetry whereby the flood was stronger. When operated concurrently, the maximum power-output at Torr Head is 64.5 MW, representing 31% reduction. If Torr Head can still operate commercially in the presence of Fair Head, then the additional environmental impact of Torr Head, such as the change in bed shear stress, is small. Within the Irish Sea, very few of the tidal projects investigated are geographically close to each other. As the industry develops, the risk of interaction to these sites will grow when more intermediary sites are developed

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis. While inflammatory cytokines, including interleukin (IL)-6, are elevated in IPF, the molecular mechanisms that underlie this disease are incompletely understood, although the development of fibrosis is believed to depend on canonical transforming growth factor (TGF)-β signalling. We examined bleomycin-induced inflammation and fibrosis in mice carrying a mutation in the shared IL-6 family receptor gp130. Using genetic complementation, we directly correlate the extent of IL-6-mediated, excessive Stat3 activity with inflammatory infiltrates in the lung and the severity of fibrosis in corresponding gp130757F mice. The extent of fibrosis was attenuated in B lymphocyte-deficient gp130757F;µMT−/− compound mutant mice, but fibrosis still occurred in their Smad3−/− counterparts consistent with the capacity of excessive Stat3 activity to induce collagen 1α1 gene transcription independently of canonical TGF-β/Smad3 signalling. These findings are of therapeutic relevance, since we confirmed abundant STAT3 activation in fibrotic lungs from IPF patients and showed that genetic reduction of Stat3 protected mice from bleomycin-induced lung fibrosis