Theoretical studies of the nucleation and growth of thin metal films: a focus on Ag deposited on Ag(100)

Theoretical studies of the nucleation and growth of metal films are performed, where the focus is the Molecular Beam Epitaxial (MBE) growth of Ag on the Ag(100) surface. Ag films grown under MBE, for the temperatures and atomic fluxes considered here (0→300K), are very far from equilibrium structures, due to the breaking of detailed balance during deposition. Included are studies of: metal film growth at very low temperatures; the temperature dependence of mound formation; the temperature dependence of kinetic roughening; the effect of the step-edge barrier on very thin films, and the post-deposition time dependence of nucleation. For these studies a range of lattice gas models are developed that are thought to contain the essential physics. These models contain such features as terrace diffusion, realistic edge diffusion process, a non-uniform Erlich-Schwoebel barrier, restricted and normal Downward Funneling, and low barrier diffusion process along micro-facets. The models were then tested by first performing a Kinetic Monte-Carlo simulation, and comparing the results to experimental data generated from previous Scanning Tunneling Microscopy studies. The models not only proved to be in good agreement with average quantities of the experimental film, but also proved to reproduce the details of the experimental morphologies quite well

Patterns of Structural Response to Simulated Partial Harvesting of Boreal Mixedwood Stands

Partial harvesting has been proposed as an approach for maintaining late-successional structure within managed boreal mixedwood stands. Although little long-term data is available to evaluate its effects in this stand type, recent advances in individual tree-based stand modeling provide an opportunity to simulate post-harvest stand development following different retention harvests. Using the stand dynamics model SORTIE-ND, we examined 40-year patterns of structural change in response to different intensities (30%, 50%, and 70% removal) and spatial patterns (uniform, small patch, large patch) of harvesting in aspen-dominated mixedwood stands. We assessed structural dynamics through a suite of variables representing the distribution of tree sizes, understory development, regeneration, standing and fallen dead wood characteristics, and within-stand heterogeneity. Partial harvesting induced a reciprocal increase in understory and downed woody debris development and decrease in overstory structure over the first 20 years after harvest, with this effect reversing after 25 years as harvest-induced regeneration reached the canopy. Densities of large trees and snags were reduced by harvesting, and did not recover to pre-harvest levels within 40 years. Harvesting promoted within-stand heterogeneity in the short and long term, and also produced transient increases in early-decay downed woody debris and ground exposure. These effects largely increased in proportion to harvest intensity. Although spatial pattern was of lesser importance than intensity, aggregated harvests induced somewhat less pronounced impacts on structure (with the exception of heterogeneity) than dispersed harvesting. These simulation results can form a basis for more detailed hypotheses regarding maintenance of late-successional stand structure and function through partial harvesting. Such hypotheses may in turn be translated into real-world silvicultural experiments to be evaluated, refined, and either accepted or rejected within an adaptive management framework

Impacts of climatic variation on the growth of black spruce across the forest-tundra ecotone : positive effects of warm growing seasons and heat waves are offset by late spring frosts

Climate strongly limits the physiological processes of trees near their range limits, leading to increased growth sensitivity. Northeastern North America is experiencing considerable warming, so the growth of trees near the northern treeline represents a key indicator of forest responses to climate change. However, tree-ring series and corresponding climatic data are scarce across the forest-tundra ecotone when compared to southern boreal regions, resulting in fewer studies on growth-climate relationships focused on this ecotone. Using daily climatic data, we identified trends in growing season heat accumulation and the intensity of acute climatic events over the last several decades in the southern and the northern parts of the forest-tundra ecotone in northeastern North America, and investigated their influence on black spruce radial growth. We found that black spruce trees responded positively to the increase in growing season temperatures and heat wave intensity, suggesting that growth is currently limited by suboptimal temperatures. While tree growth in the southern region generally benefited from warm spring temperatures, vulnerability to late spring frosts reduced tree growth in the northern region and increased probability of abrupt growth decline. In this region, late spring frosts offset approximately half of the additional growth that would otherwise occur over the course of a warm growing season. This vulnerability of northern trees may result from local adaptations to short growing seasons, which initiate biological activities at colder temperatures in the spring. Overall, our results highlight the need to explicitly incorporate acute climatic events into modeling efforts in order to refine our understanding of the impact of climate change on forest dynamics

BACE1 activity impairs neuronal glucose oxidation:rescue by beta-hydroxybutyrate and lipoic acid

Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), responsible for beta amyloid peptide generation, has recently been demonstrated to modify glucose metabolism. We therefore examined, using a human neuroblastoma (SH-SY5Y) cell line, whether increased BACE1 activity is responsible for a reduction in cellular glucose metabolism. Overexpression of active BACE1, but not a protease-dead mutant BACE1, protein in SH-SY5Y cells reduced glucose oxidation and the basal oxygen consumption rate, which was associated with a compensatory increase in glycolysis. Increased BACE1 activity had no effect on the mitochondrial electron transfer process but was found to diminish substrate delivery to the mitochondria by inhibition of key mitochondrial decarboxylation reaction enzymes. This BACE1 activity-dependent deficit in glucose oxidation was alleviated by the presence of beta hydroxybutyrate or α-lipoic acid. Consequently our data indicate that raised cellular BACE1 activity drives reduced glucose oxidation in a human neuronal cell line through impairments in the activity of specific tricarboxylic acid cycle enzymes. Because this bioenergetic deficit is recoverable by neutraceutical compounds we suggest that such agents, perhaps in conjunction with BACE1 inhibitors, may be an effective therapeutic strategy in the early-stage management or treatment of AD

A critique of general allometry-inspired models for estimating forest carbon density from airborne LiDAR.

There is currently much interest in developing general approaches for mapping forest aboveground carbon density using structural information contained in airborne LiDAR data. The most widely utilized model in tropical forests assumes that aboveground carbon density is a compound power function of top of canopy height (a metric easily derived from LiDAR), basal area and wood density. Here we derive the model in terms of the geometry of individual tree crowns within forest stands, showing how scaling exponents in the aboveground carbon density model arise from the height-diameter (H-D) and projected crown area-diameter (C-D) allometries of individual trees. We show that a power function relationship emerges when the C-D scaling exponent is close to 2, or when tree diameters follow a Weibull distribution (or other specific distributions) and are invariant across the landscape. In addition, basal area must be closely correlated with canopy height for the approach to work. The efficacy of the model was explored for a managed uneven-aged temperate forest in Ontario, Canada within which stands dominated by sugar maple (Acer saccharum Marsh.) and mixed stands were identified. A much poorer goodness-of-fit was obtained than previously reported for tropical forests (R2 = 0.29 vs. about 0.83). Explanations for the poor predictive power on the model include: (1) basal area was only weakly correlated with top canopy height; (2) tree size distributions varied considerably across the landscape; (3) the allometry exponents are affected by variation in species composition arising from timber management and soil conditions; and (4) the C-D allometric power function was far from 2 (1.28). We conclude that landscape heterogeneity in forest structure and tree allometry reduces the accuracy of general power-function models for predicting aboveground carbon density in managed forests. More studies in different forest types are needed to understand the situations in which power functions of LiDAR height are appropriate for modelling forest carbon stocks

Opportunities and limitations of thinning to increase resistance and resilience of trees and forests to global change

We reviewed recent literature to identify the positive and negative effects of thinning on both stand- and tree-level resistance and resilience to four stressors that are expected to increase in frequency and/or severity due to global change: (1) drought, (2) fire, (3) insects and pathogens, and (4) wind. There is strong evidence that thinning, particularly heavy thinning, reduces the impact of drought and also the risk and severity of fire when harvest slash is burned or removed. Thinning also increases the growth and vigor of residual trees, making them less susceptible to eruptive insects and pathogens, while targeted removal of host species, susceptible individuals and infected trees can slow the spread of outbreaks. However, the evidence that thinning has consistent positive effects is limited to a few insects and pathogens, and negative effects on root rot infection severity were also reported. At this point, our review reveals insufficient evidence from rigorous experiments to draw general conclusions. Although thinning initially increases the risk of windthrow, there is good evidence that thinning young stands reduces the long-term risk by promoting the development of structural roots and favouring the acclimation of trees to high wind loads. While our review suggests that thinning should not be promoted as a tool that will universally increase the resistance and resilience of forests, current evidence suggests that thinning could still be an effective tool to reduce forest vulnerability to several stressors, creating a window of opportunity to implement longer term adaptive management strategies such as assisted migration. We highlight knowledge gaps that should be targeted by future research to assess the potential contribution of thinning to adaptive forest management. One of these gaps is that studies from boreal and tropical regions are drastically underrepresented, with almost no studies conducted in Asia and the southern hemisphere. Empirical evidence from these regions is urgently needed to allow broader-scale conclusions

Research Exploring Physical Activity in Care Homes (REACH): study protocol for a randomised controlled trial

Background: As life expectancy increases and the number of older people, particularly those aged 85 years and over, expands there is an increase in demand for long-term care. A large proportion of people in a care home setting spend most of their time sedentary, and this is one of the leading preventable causes of death. Encouraging residents to engage in more physical activity could deliver benefits in terms of physical and psychological health, and quality of life. This study is the final stage of a programme of research to develop and preliminarily test an evidence-based intervention designed to enhance opportunities for movement amongst care home residents, thereby increasing levels of physical activity. Methods/design: This is a cluster randomised feasibility trial, aiming to recruit at least 8–12 residents at each of 12 residential care homes across Yorkshire, UK. Care homes will be randomly allocated on a 1:1 basis to receive either the intervention alongside usual care, or to continue to provide usual care alone. Assessment will be undertaken with participating residents at baseline (prior to care home randomisation) and at 3, 6, and 9 months post-randomisation. Data relating to changes in physical activity, physical function, level of cognitive impairment, mood, perceived health and wellbeing, and quality of life will be collected. Data at the level of the home will also be collected and will include staff experience of care, and changes in the numbers and types of adverse events residents experience (for example, hospital admissions, falls). Details of National Health Service (NHS) usage will be collected to inform the economic analysis. An embedded process evaluation will obtain information to test out the theory of change underpinning the intervention and its acceptability to staff and residents. Discussion: This feasibility trial with embedded process evaluation and collection of health economic data will allow us to undertake detailed feasibility work to inform a future large-scale trial. It will provide valuable information to inform research procedures in this important but challenging area

Plant functional traits have globally consistent effects on competition.

Phenotypic traits and their associated trade-offs have been shown to have globally consistent effects on individual plant physiological functions, but how these effects scale up to influence competition, a key driver of community assembly in terrestrial vegetation, has remained unclear. Here we use growth data from more than 3 million trees in over 140,000 plots across the world to show how three key functional traits--wood density, specific leaf area and maximum height--consistently influence competitive interactions. Fast maximum growth of a species was correlated negatively with its wood density in all biomes, and positively with its specific leaf area in most biomes. Low wood density was also correlated with a low ability to tolerate competition and a low competitive effect on neighbours, while high specific leaf area was correlated with a low competitive effect. Thus, traits generate trade-offs between performance with competition versus performance without competition, a fundamental ingredient in the classical hypothesis that the coexistence of plant species is enabled via differentiation in their successional strategies. Competition within species was stronger than between species, but an increase in trait dissimilarity between species had little influence in weakening competition. No benefit of dissimilarity was detected for specific leaf area or wood density, and only a weak benefit for maximum height. Our trait-based approach to modelling competition makes generalization possible across the forest ecosystems of the world and their highly diverse species composition.We are especially grateful to the researchers whose long-term commitment to establish and maintain forest plots and their associated databases made this study possible, and to those who granted us data access: forest inventories and permanent plots of New Zealand, Spain (MAGRAMA), France, Switzerland, Sweden, US and Canada (for the provinces of Quebec provided by the Ministère des Ressources Naturelles du Québec, Ontario provided by OnTAP’s Growth and Yield Program of the Ontario Ministry of Natural Resources, Saskatchewan, Manitoba, New Brunswick, Newfoundland and Labrador), CTFS (BCI and LTER-Luquillo), Taiwan (Fushan), Cirad (Paracou with funding by CEBA, ANR-10-LABX-25-01), Cirad, MEFCP and ICRA (M’Baïki) and Japan. We thank MPI-BGC Jena, who host TRY, and the international funding networks supporting TRY (IGBP, DIVERSITAS, GLP, NERC, QUEST, FRB and GIS Climate). G.K. was supported by a Marie Curie International Outgoing Fellowship within the 7th European Community Framework Program (Demo-Traits project, no. 299340). The working group that initiated this synthesis was supported by Macquarie University and by Australian Research Council through a fellowship to M.W.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/nature1647

Does Habitual Physical Activity Increase the Sensitivity of the Appetite Control System? A Systematic Review.

BACKGROUND: It has been proposed that habitual physical activity improves appetite control; however, the evidence has never been systematically reviewed. OBJECTIVE: To examine whether appetite control (e.g. subjective appetite, appetite-related peptides, food intake) differs according to levels of physical activity. DATA SOURCES: Medline, Embase and SPORTDiscus were searched for articles published between 1996 and 2015, using keywords pertaining to physical activity, appetite, food intake and appetite-related peptides. STUDY SELECTION: Articles were included if they involved healthy non-smoking adults (aged 18-64 years) participating in cross-sectional studies examining appetite control in active and inactive individuals; or before and after exercise training in previously inactive individuals. STUDY APPRAISAL AND SYNTHESIS: Of 77 full-text articles assessed, 28 studies (14 cross-sectional; 14 exercise training) met the inclusion criteria. RESULTS: Appetite sensations and absolute energy intake did not differ consistently across studies. Active individuals had a greater ability to compensate for high-energy preloads through reductions in energy intake, in comparison with inactive controls. When physical activity level was graded across cross-sectional studies (low, medium, high, very high), a significant curvilinear effect on energy intake (z-scores) was observed. LIMITATIONS: Methodological issues existed concerning the small number of studies, lack of objective quantification of food intake, and various definitions used to define active and inactive individuals. CONCLUSION: Habitually active individuals showed improved compensation for the energy density of foods, but no consistent differences in appetite or absolute energy intake, in comparison with inactive individuals. This review supports a J-shaped relationship between physical activity level and energy intake. Further studies are required to confirm these findings. PROSPERO REGISTRATION NUMBER: CRD42015019696