Rural sustainable drainage systems:a practical design and build guide for Scotland's farmers and landowners

Soil cultivation, manure / fertiliser applications and chemical spraying can all contribute to diffuse pollution from agricultural land. Rainfall runoff from farm roads, tracks, yards and dusty roofs are also potential sources of diffuse pollution. Whilst many changes in farming practice have dealt with these sources of pollution there still remains instances where small amounts escape from a farmyard into a nearby ditch or where sediment laden overland field flows make their way into a ditch or burn, river or natural wetland and finally the sea. This not only has cost implications for a farmer but these incidents across a catchment have a huge impact on our water environment. Rural Sustainable Drainage Systems (Rural SuDS) will reduce agricultural diffuse pollution impacts as they are physical barriers that treat rainfall runoff. They are low cost, above ground drainage structures that capture soil particles, organic matter, nutrients and pesticides before they enter our water environment. Rural SuDS for steadings prevent blockages in drains and ditches. They contribute to good environmental practice and farm assurance schemes. In fields they can be used for returning fertile soil back to farmland and will help your business become more resilient to the impacts of climate change. Trapping soils, organic matter and nutrients means that valuable assets can be reclaimed – recent studies indicate savings of £88 per hectare per year! This Design and Build guide can be used by farmers and land managers to reduce diffuse pollution

Book Reviews

Book Reviews: Overthrow: America's Century of Regime Change From Hawaii to Iraq by Stephen Kinzer ; Longitude and Empire: How Captain Cook's Voyages Changed the World by Brian W. Richardson ; Pacific Encounters: Art & Diversity in Polynesia 1760-1860 by Steven Hooper ; All Men Are Brothers: The Life & Times of Francis Williams Damon by Paul Berry ; Broken Trust: Greed, Mismanagement, & Political Manipulation at America's Largest Charitable Trust by Samuel P. King and Randall W. Roth ; Crowning the Nice Girl: Gender, Ethnicity, and Culture in Hawai'i's Cherry Blossom Festival by Christine R. Yano ; Combat Chaplain: The Personal Story of the World War II Chaplain of the Japanese American 100th Battalion by Israel A. S. Yost ; Hawaiian Volcanoes by Clarence Edward Dutton ; Reworking Race: The Making of Hawaii's Interracial Labor Movement by Moon-Kie Jung ; Islands in a Far Sea: The Fate of Nature in Hawai'i by John L. Culliney

Barking Up the Wrong Tree? Reconsidering Policy Compliance as a Dependent Variable within Behavioral Cybersecurity Research

A rich body of research examines the cybersecurity behavior of employees, with a particular focus on explaining the reasons why employees comply with (or violate) organizational cybersecurity policies. However, we posit that this emphasis on policy compliance is susceptible to several notable limitations that could lead to inaccurate research conclusions. In this commentary, we examine the limitations of using cybersecurity policy compliance as a dependent variable by presenting three assertions: (1) the link between policy compliance and organizational-level outcomes is ambiguous; (2) policies vary widely in terms of their clarity and completeness; and (3) employees have an inconsistent familiarity with their own organization’s cybersecurity policies. Taken together, we suggest that studying compliance with cybersecurity policies reveals only a partial picture of employee behavior. In response, we offer recommendations for future research

FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1)

Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease with no effective treatment. The genetic cause of FSHD is complex and the primary pathogenic insult underlying the muscle disease is unknown. Several disease candidate genes have been proposed including DUX4 and FRG1. Expression analysis studies of FSHD report the deregulation of genes which mediate myoblast differentiation and fusion. Transgenic mice overexpressing FRG1 recapitulate the FSHD muscular dystrophy phenotype. Our current study selectively examines how increased expression of FRG1 may contribute to myoblast differentiation defects. We generated stable C2C12 cell lines overexpressing FRG1, which exhibited a myoblast fusion defect upon differentiation. To determine if myoblast fusion defects contribute to the FRG1 mouse dystrophic phenotype, this strain was crossed with skeletal muscle specific FHL1-transgenic mice. We previously reported that FHL1 promotes myoblast fusion in vitro and FHL1-transgenic mice develop skeletal muscle hypertrophy. In the current study, FRG1 mice overexpressing FHL1 showed an improvement in the dystrophic phenotype, including a reduced spinal kyphosis, increased muscle mass and myofiber size, and decreased muscle fibrosis. FHL1 expression in FRG1 mice, did not alter satellite cell number or activation, but enhanced myoblast fusion. Primary myoblasts isolated from FRG1 mice showed a myoblast fusion defect that was rescued by FHL1 expression. Therefore, increased FRG1 expression may contribute to a muscular dystrophy phenotype resembling FSHD by impairing myoblast fusion, a defect that can be rescued by enhanced myoblast fusion via expression of FHL1

Trends in, and predictors of, anxiety and specific worries following colposcopy: a 12-month longitudinal study

Objective Little is known about which women are at greatest risk of adverse psychological after-effects following colposcopy. This study examined time trends in, and identified predictors of, anxiety and specific worries over 12 months. Methods Women attending two hospital-based colposcopy clinics for abnormal cervical cytology were invited to complete psychosocial questionnaires at 4, 8 and 12 months following colposcopy. General anxiety and screening-specific worries (about cervical cancer, having sex and future fertility) were measured. Generalised estimating equations were used to assess associations between socio-demographic, lifestyle and clinical variables and risk of psychological outcomes. Results Of 584 women initially recruited, 429, 343 and 303 completed questionnaires at 4, 8 and 12 months, respectively. Screening-specific worries declined significantly over time but were still relatively high at 12 months: 23%, 39% and 18% for worries about cervical cancer, fertility and having sex, respectively. Anxiety remained stable (20%) over time. Risks of cervical cancer worry and anxiety were both almost double in women without private health insurance (cervical cancer worry: OR = 1.80, 95% CI 1.25–2.61; anxiety: OR = 1.84, 95% CI 1.20–2.84). Younger women (<40 years) had higher risk of fertility worries. Non-Irish women had higher risk of anxiety (OR = 2.13, 95% CI 1.13–4.01). Conclusions Screening-specific worries declined over time but anxiety remained stable. Notable proportions of women still reported adverse outcomes 12 months following colposcopy, with predictors varying between outcomes. Women in socio-demographically vulnerable groups were at greatest risk of adverse psychological outcomes. This information could inform development of interventions to alleviate psychological distress post-colposcopy. Copyright © 2015 John Wiley & Sons, Ltd

The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer

The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance. This study aims to provide further evidence that MyD88 positive cancer cells are clinically significant, stem-like and reproducibly detectable for the purposes of prognostic stratification. Expression of TLR4 and MyD88 was assessed immunohistochemically in 198 paraffin-embedded ovarian tissues and in an embryonal carcinoma model of cancer stemness. In parallel, expression of TLR4 and MyD88 mRNA and regulatory microRNAs (miR-21 and miR-146a) was assessed, as well as in a series of chemosensitive and resistant cancer cells lines. Functional analysis of the pathway was assessed in chemoresistant SKOV-3 ovarian cancer cells. TLR4 and MyD88 expression can be reproducibly assessed via immunohistochemistry using a semi-quantitative scoring system. TLR4 expression was present in all ovarian epithelium (normal and neoplastic), whereas MyD88 was restricted to neoplastic cells, independent of tumour grade and associated with reduced progression-free and overall survival, in an immunohistological specific subset of serous carcinomas, p<0.05. MiR-21 and miR-146a expression was significantly increased in MyD88 negative cancers (p<0.05), indicating their participation in regulation. Significant alterations in MyD88 mRNA expression were observed between chemosensitive and chemoresistant cells and tissue. Knockdown of TLR4 in SKOV-3 ovarian cells recovered chemosensitivity. Knockdown of MyD88 alone did not. MyD88 expression was down-regulated in differentiated embryonal carcinoma (NTera2) cells, supporting the MyD88+ cancer stem cell hypothesis. Our findings demonstrate that expression of MyD88 is associated with significantly reduced patient survival and altered microRNA levels and suggest an intact/functioning TLR4/MyD88 pathway is required for acquisition of the chemoresistant phenotype. Ex vivo manipulation of ovarian cancer stem cell (CSC) differentiation can decrease MyD88 expression, providing a potentially valuable CSC model for ovarian cancer

Rural sustainable drainage systems:a practical design and build guide for Scotland's farmers and landowners

Soil cultivation, manure / fertiliser applications and chemical spraying can all contribute to diffuse pollution from agricultural land. Rainfall runoff from farm roads, tracks, yards and dusty roofs are also potential sources of diffuse pollution. Whilst many changes in farming practice have dealt with these sources of pollution there still remains instances where small amounts escape from a farmyard into a nearby ditch or where sediment laden overland field flows make their way into a ditch or burn, river or natural wetland and finally the sea. This not only has cost implications for a farmer but these incidents across a catchment have a huge impact on our water environment. Rural Sustainable Drainage Systems (Rural SuDS) will reduce agricultural diffuse pollution impacts as they are physical barriers that treat rainfall runoff. They are low cost, above ground drainage structures that capture soil particles, organic matter, nutrients and pesticides before they enter our water environment. Rural SuDS for steadings prevent blockages in drains and ditches. They contribute to good environmental practice and farm assurance schemes. In fields they can be used for returning fertile soil back to farmland and will help your business become more resilient to the impacts of climate change. Trapping soils, organic matter and nutrients means that valuable assets can be reclaimed – recent studies indicate savings of £88 per hectare per year! This Design and Build guide can be used by farmers and land managers to reduce diffuse pollution

A marginal modelling approach for predicting wildfire extremes across the contiguous United States

This paper details a methodology proposed for the EVA 2021 conference data challenge. The aim of this challenge was to predict the number and size of wildfires over the contiguous US between 1993 and 2015, with more importance placed on extreme events. In the data set provided, over 14\% of both wildfire count and burnt area observations are missing; the objective of the data challenge was to estimate a range of marginal probabilities from the distribution functions of these missing observations. To enable this prediction, we make the assumption that the marginal distribution of a missing observation can be informed using non-missing data from neighbouring locations. In our method, we select spatial neighbourhoods for each missing observation and fit marginal models to non-missing observations in these regions. For the wildfire counts, we assume the compiled data sets follow a zero-inflated negative binomial distribution, while for burnt area values, we model the bulk and tail of each compiled data set using non-parametric and parametric techniques, respectively. Cross validation is used to select tuning parameters, and the resulting predictions are shown to significantly outperform the benchmark method proposed in the challenge outline. We conclude with a discussion of our modelling framework, and evaluate ways in which it could be extended.Comment: 13 pages, 5 figure

Stress in the cybersecurity profession: a systematic review of related literature and opportunities for future research

Purpose – The impact of stress on personal and work-related outcomes has been studied in the information systems (IS) literature across several professions. However, the cybersecurity profession has received little attention despite numerous reports suggesting stress is a leading cause of various adverse professional outcomes. Cybersecurity professionals work in a constantly changing adversarial threat landscape, are focused on enforcement rather than compliance, and are required to adhere to ever-changing industry mandates – a work environment that is stressful and has been likened to a war zone. Hence, this literature review aims to reveal gaps and trends in the current extant general workplace and IS-specific stress literature and illuminate potentially fruitful paths for future research focused on stress among cybersecurity professionals. Design/methodology/approach – Using the systematic literature review process (Okoli and Schabram, 2010), the authors examined the current IS research that studies stress in organizations. A disciplinary corpus was generated from IS journals and conferences encompassing 30 years. The authors analyzed 293 articles from 21 journals and six conferences to retain 77 articles and four conference proceedings for literature review. Findings – The findings reveal four key research opportunities. First, the demands experienced by cybersecurity professionals are distinct from the demands experienced by regular information technology (IT) professionals. Second, it is crucial to identify the appraisal process that cybersecurity professionals follow in assessing security demands. Third, there are many stress responses from cybersecurity professionals, not just negative responses. Fourth, future research should focus on stress-related outcomes such as employee productivity, job satisfaction, job turnover, etc., and not only security compliance among cybersecurity professionals. Originality/value – This study is the first to provide a systematic synthesis of the IS stress literature to reveal gaps, trends and opportunities for future research focused on stress among cybersecurity professionals. The study presents several novel trends and research opportunities. It contends that the demands experienced by cybersecurity professionals are distinct from those experienced by regular IT professionals and scholars should seek to identify the key characteristics of these demands that influence their appraisal process. Also, there are many stress responses, not just negative responses, deserving increased attention and future research should focus on unexplored stress-related outcomes for cybersecurity professionals

Denial of long-term issues with agriculture on tropical peatlands will have devastating consequences

Letter to the Editor