Prompt Reversal of Airway Obstruction Secondary to Angiotensin Converting Enzyme Inhibitor (ACEI) Induced Angioedema by Ecallantide: A Case Report

Case: A 54 year old African-American male with a history of hypertension treated with lisinopril daily, remote cocaine abuse associated myocardial infarction, seizures and prostate cancer, presented with a 2 day history of facial and throat swelling along with dysphagia. He was treated in the emergency department with intravenous methylprednisolone, epinephrine and diphenhydramine. He was admitted, but angioedema progressed overnight, confirmed by laryngoscopy. ICU transfer and intubation was undertaken the next morning for airway protection. Tryptase level was 2 ng/ml. C3 and C4 and routine chemistries were normal. Ecallantide 30mg was administered subcutaneously at 1014 hours. Presented at: American Academy of Allergy Asthma and Immunology annual conference in Orlando Florida

Prostitution and Casual Sex: An Examination of Kantian Ethics and the Moral Acceptability of Prostitution

This paper concerns the ethics of prostitution. It begins with David Benatar’s distinction between “significant” and “casual” sex. Kant’s understanding of sex—fraught with worries about ends, autonomy, and objectification—falls under the significance view of sex, even more “special” because it seems to hold that sex is only morally acceptable within marriage. But this untenable position exposes an inconsistency in Kant’s thoughts on personhood and possession. Singer offers a preferable view of sex as sustenance. The author next argues that the service of prostitution is ethical so long as the prostitute’s job and her or his personal life remain distinct, the body is not harmed, and the prostitute chooses to prostitute. The author then dismisses dissenting opinions from Melissa Farley and Howard Klepper, who misplace the cause of psychological harm and misidentify coercion, respectively. The paper concludes with an analogy connecting the prostitute’s services with a Santa Claus impersonator’s service

Rethinking police accountability and transparency within the EU: reconciling national and supranational approaches

The new terrain of increasing interaction between national and supranational legal systems within the European Union presents new challenges for conventional approaches to police accountability and transparency. Each EU Member State is responsible for policing within its jurisdiction, and the EU institutions are increasingly responsible for enhancing the conduct of police cooperation between the Member States. The thesis explores the challenges of reconciling national approaches in the international sphere by conducting a critical analysis of ‘how and to what extent national legal and administrative norms on police accountability and transparency are informing the concept, design and operation of EU cross-border policing instruments’. Building on the work of Peter K. Manning, Geoffrey Marshall and David Bayley amongst others, the thesis develops a pragmatic typology of police accountability through which to view the evolution and adequacy of national and supranational approaches. The typology contains three key dimensions, namely codes, co-option and complaint. Using the typology to critique conventional approaches in the UK, Ireland and Denmark, the thesis identifies legal and procedural anomalies and challenges at both the national and supranational level since the traditional elements of police accountability were originally formulated within the confines of national legal, political, historical and cultural constraints. Employing the typology to both elucidate problems and suggest methods of internalisation, the thesis argues that the EU should follow the lead of the Member States’ legislatures by seeking to regulate a wider range of policing processes through more expansive procedural ‘codes’ which facilitate police discretion and co-option. The thesis shows that it is not sufficient for the EU to prioritise its post-Lisbon policy of ‘co-decision’ in order to remedy its democratic deficits but that it must oversee the establishment and enhancement of parliamentary committees, inspectorates and other oversight bodies in the interest of police accountability. A number of recommendations are made for police reform at both the national and supranational levels to this end. More particularly, the research indicates that additional treaty changes are needed beyond the Lisbon Treaty in order to adequately reconcile national and supranational approaches to police accountability. I am grateful to the Irish Research Council for supporting this research by the award of a Government of Ireland Research Scholarship

Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients

Background.: We and others have demonstrated that a low level of donor cell chimerism was present for years after transplantation in tissues and peripheral blood of heart and lung recipients; it was associated, in the latter, with a lower incidence of chronic rejection. To augment this phenomenon, we initiated a trial combining simultaneous infusion of donor bone marrow with heart or lung allotransplantation. Methods.: Between September 1993 and January 1995, 15 nonconditioned patients received either heart (n = 10) or lung (n = 5) allografts concurrently with an infusion of unmodified donor bone marrow (3.0 × 108 cells/kg), and were maintained on an immunosuppressive regimen consisting of tacrolimus and steroids. Results.: There was no complication associated with the infusion of donor bone marrow. Chimerism was detectable in 73% of bone marrow-augmented patients up to the last sample tested. Of the 5 control recipients who did not receive bone marrow infusion, only 1 had detectable chimerism by flow on postoperative day 15, which dwindled to an undetectable level by postoperative day 36. None of the patients had evidence of donor-specific immune modulation by mixed lymphocyte reaction. Conclusions.: The combined infusion of donor bone marrow and heart or lung transplantation, without preconditioning of the recipient, is safe and is associated with an augmentation of donor cell chimerism. © 1995 The Society of Thoracic Surgeons

Torso stabilization reduces the metabolic cost of producing cycling power

Journal ArticleMany researchers have used cycling exercise to evaluate muscle metabolism. Inherent in such studies is an assumption that changes in whole-body respiration are due solely to respiration at the working muscle. Some researchers, however, have speculated that the metabolic cost of torso stabilization may contribute to the metabolic cost of cycling

Prospective memory functioning among ecstasy/polydrug users: evidence from the Cambridge Prospective Memory Test (CAMPROMPT)

Rationale: Prospective memory (PM) deficits in recreational drug users have been documented in recent years. However, the assessment of PM has largely been restricted to self-reported measures that fail to capture the distinction between event-based and time-based PM. The aim of the present study is to address this limitation. Objectives: Extending our previous research, we augmented the range laboratory measures of PM by employing the CAMPROMPT test battery to investigate the impact of illicit drug use on prospective remembering in a sample of cannabis only, ecstasy/polydrug and non-users of illicit drugs, separating event and time-based PM performance. We also administered measures of executive function and retrospective memory in order to establish whether ecstasy/polydrug deficits in PM were mediated by group differences in these processes. Results: Ecstasy/polydrug users performed significantly worse on both event and time-based prospective memory tasks in comparison to both cannabis only and non-user groups. Furthermore, it was found that across the whole sample, better retrospective memory and executive functioning was associated with superior PM performance. Nevertheless, this association did not mediate the drug-related effects that were observed. Consistent with our previous study, recreational use of cocaine was linked to PM deficits. Conclusions: PM deficits have again been found among ecstasy/polydrug users, which appear to be unrelated to group differences in executive function and retrospective memory. However, the possibility that these are attributable to cocaine use cannot be excluded

Wind Ensemble and Concert Band

Kennesaw State University School of Music presents Wind Ensemble and Concert Band.https://digitalcommons.kennesaw.edu/musicprograms/1617/thumbnail.jp

Farancia abacura

Number of Pages: 2Integrative BiologyGeological Science