PDF uncertainties: A strong test of goodness of fit to multiple data sets

We present a new criterion for the goodness of global fits. It involves an exploration of the variation of \chi^2 for subsets of data.Comment: 4 pages, 1 figure. To appear in Proceedings of 9th International Workshop on Deep Inelastic Scattering and QCD (DIS 2001), Bologna, Italy, 27 Apr-1 May 200

Are life-extending treatments for terminal illnesses a special case? Exploring choices and societal viewpoints

Criteria used by the National Institute for Health and Care Excellence (NICE) to assess life-extending, end-of-life (EoL) treatments imply that health gains from such treatments are valued more than other health gains. Despite claims that the policy is supported by societal values, evidence from preference elicitation studies is mixed and in-depth research has shown there are different societal viewpoints. Few studies elicit preferences for policies directly or combine different approaches to understand preferences.Survey questions were designed to investigate support for NICE EoL guidance at national and regional levels. These ‘Decision Rule’ and ‘Treatment Choice’ questions were administered to an online sample of 1496 UK respondents in May 2014. The same respondents answered questions designed to elicit their agreement with three viewpoints (previously identified and described) in relation to provision of EoL treatments for terminally ill patients. We report the findings of these choice questions and examine how they relate to each other and respondents' viewpoints.The Decision Rule questions described three policies: DA – a standard ‘value for money’ test, applied to all health technologies; DB – giving special consideration to all treatments for terminal illnesses; and DC – giving special consideration to specific categories of treatments for terminal illnesses e.g. life extension (as in NICE EoL guidance) or those that improve quality-of-life (QoL). Three Treatment Choices were presented: TA – improving QoL for patients with a non-terminal illness; TB – extending life for EoL patients; and TC – improving QoL at the EoL.DC received most support (45%) with most respondents giving special consideration to EoL only when treatments improved QoL. The most commonly preferred treatment choices were TA (51%) and TC (43%). Overall, this study challenges claims about public support for NICE's EoL guidance and the focus on life extension at EoL and substantiates existing evidence of plurality in societal values

Towards a generic research data management infrastructure

Until recent years, a focused and centralized strategy for the annotation, storage and curation of research data is something that has not been widely considered within academic communities. The majority of research data sits, fragmented, on a variety of disk structures (Desktops, network & external hard drives) and is usually managed locally, with little interest paid to policies governing how it is backed up, disseminated and organized for short or long term reuse. Recognition of how current practices and infrastructure present a barrier to research, has resulted in several recent academic programmes which have focused on developing comprehensive frameworks for the management and curation of research data1-3. Many of these frameworks (such as the Archer suite of e- Research tools1), however, are large and complex, and have an overreliance on new and novel technologies making them unwieldy and difficult to support. The paper discusses the development of a simpler framework for the management of research data through its full lifecycle, allowing users to annotate and structure their research in a secure and backed up environment. The infrastructure is being developed as a pilot system and is expected to work with data from approximately a dozen researchers and manage several Terabytes of data. The technical work is a strand of the MaDAM (Manchester Data Management) project at The University of Manchester which is funded by the JISC Managing Research Data Programme.

The Purple Haze of Eta Carinae: Binary-Induced Variability?

Asymmetric variability in ultraviolet images of the Homunculus obtained with the Advanced Camera for Surveys/High Resolution Camera on the Hubble Space Telescope suggests that Eta Carinae is indeed a binary system. Images obtained before, during, and after the recent ``spectroscopic event'' in 2003.5 show alternating patterns of bright spots and shadows on opposite sides of the star before and after the event, providing a strong geometric argument for an azimuthally-evolving, asymmetric UV radiation field as one might predict in some binary models. The simplest interpretation of these UV images, where excess UV escapes from the secondary star in the direction away from the primary, places the major axis of the eccentric orbit roughly perpendicular to our line of sight, sharing the same equatorial plane as the Homunculus, and with apastron for the hot secondary star oriented toward the southwest of the primary. However, other orbital orientations may be allowed with more complicated geometries. Selective UV illumination of the wind and ejecta may be partly responsible for line profile variations seen in spectra. The brightness asymmetries cannot be explained plausibly with delays due to light travel time alone, so a single-star model would require a seriously asymmetric shell ejection.Comment: 8 pages, fig 1 in color, accepted by ApJ Letter

Development of a pilot data management infrastructure for biomedical researchers at University of Manchester – approach, findings, challenges and outlook of the MaDAM Project

Management and curation of digital data has been becoming ever more important in a higher education and research environment characterised by large and complex data, demand for more interdisciplinary and collaborative work, extended funder requirements and use of e-infrastructures to facilitate new research methods and paradigms. This paper presents the approach, technical infrastructure, findings, challenges and outlook (including future development within the successor project, MiSS) of the ‘MaDAM: Pilot data management infrastructure for biomedical researchers at University of Manchester’ project funded under the infrastructure strand of the JISC Managing Research Data (JISCMRD) programme. MaDAM developed a pilot research data management solution at the University of Manchester based on biomedical researchers’ requirements, which includes technical and governance components with the flexibility to meet future needs across multiple research groups and disciplines

Participation in developing youth mental health services: ‘Cinderella Service’ to service re-design

Whilst there are pockets of excellence in the provision of Child and Adolescent Mental Health Services (CAMHS), many services fail to meet young people’s needs. Considering this, the current research aimed to ascertain perceptions of CAMHS provision in a rural county of the UK to inform re-design of youth mental health services. Design Methodology and Approach: The study comprised of two phases: phase one involved analysis of questionnaire data of youth views of CAMHS. Phase two involved analysis of the ‘Have Your Say’ event data which explored perceptions of CAMHS and future service re-design. Data were thematically analysed. Findings: Knowledge of the existence and purpose of CAMHS was variable. Participants wanted accessible information about services, rights, confidentiality and for this to be provided in multiple medias. Young people wanted staff that are easy to talk to, genuine, understanding and who value their insights. Participants wanted to be offered choice about appointments, location and timing. An ideal mental health service was described as a ‘one-stop-shop’ of co-locality and multi-agency collaboration. Young people clearly expressed a desire to influence the design and delivery of the radical re-design and to be embedded in its development. Practical Implications: The results highlighted multiple problems with CAMHS provision and provided a clear justification for the re-design of services. Originality/value: This was a novel approach demonstrating the importance, utility and power of effective participatory practices for informing the re-design of services

AZEuS: An Adaptive Zone Eulerian Scheme for Computational MHD

A new adaptive mesh refinement (AMR) version of the ZEUS-3D astrophysical magnetohydrodynamical (MHD) fluid code, AZEuS, is described. The AMR module in AZEuS has been completely adapted to the staggered mesh that characterises the ZEUS family of codes, on which scalar quantities are zone-centred and vector components are face-centred. In addition, for applications using static grids, it is necessary to use higher-order interpolations for prolongation to minimise the errors caused by waves crossing from a grid of one resolution to another. Finally, solutions to test problems in 1-, 2-, and 3-dimensions in both Cartesian and spherical coordinates are presented.Comment: 52 pages, 17 figures; Accepted for publication in ApJ

Measuring Parton Densities in the Pomeron

We present a program to measure the parton densities in the pomeron using diffractive deep inelastic scattering and diffractive photoproduction, and to test the resulting parton densities by applying them to other processes such as the diffractive production of jets in hadron-hadron collisions. Since QCD factorization has been predicted NOT to apply to hard diffractive scattering, this program of fitting and using parton densities might be expected to fail. Its success or failure will provide useful information on the space-time structure of the pomeron.Comment: Contains revisions based on Phys. Rev. D referee comments. RevTeX version 3, epsf, 31 pages. Uuencoded compressed postscript figures appended. Uncompressed postscript files available at ftp://ftp.phys.psu.edu/pub/preprint/psuth136

Phylogenetics of Trachylina (Cnidaria: Hydrozoa) with new insights on the evolution of some problematical taxa

Some of the most interesting and enigmatic cnidarians are classified within the hydrozoan subclass Trachylina. Despite being relatively depauperate in species richness, the clade contains four taxa typically accorded ordinal status: Actinulida, Limnomedusae, Narcomedusae and Trachymedusae. We bring molecular data (mitochondrial 16S and nuclear small and large subunit ribosomal genes) to bear on the question of phylogenetic relationships within Trachylina. Surprisingly, we find that a diminutive polyp form, Microhydrula limopsicola (classified within Limnomedusae) is actually a previously unknown life stage of a species of Stauromedusae. Our data confirm that the interstitial form Halammohydra sp. (Actinulida) is derived from holopelagic direct developing ancestors, likely within the trachymedusan family Rhopalonematidae. Trachymedusae is shown to be diphyletic, suggesting that the polyp stage has been lost independently at least two times within trachyline evolution. Narcomedusae is supported as a monophyletic group likely also arising from trachymedusan ancestors. Finally, some data, albeit limited, suggest that some trachyline species names refer to cryptic species that have yet to be sorted taxonomicall