Recombination Algorithms and Jet Substructure: Pruning as a Tool for Heavy Particle Searches

We discuss jet substructure in recombination algorithms for QCD jets and single jets from heavy particle decays. We demonstrate that the jet algorithm can introduce significant systematic effects into the substructure. By characterizing these systematic effects and the substructure from QCD, splash-in, and heavy particle decays, we identify a technique, pruning, to better identify heavy particle decays into single jets and distinguish them from QCD jets. Pruning removes protojets typical of soft, wide angle radiation, improves the mass resolution of jets reconstructing a heavy particle decay, and decreases the QCD background. We show that pruning provides significant improvements over unpruned jets in identifying top quarks and W bosons and separating them from a QCD background, and may be useful in a search for heavy particles.Comment: 33 pages, 42 figure

The Stability of an Isotropic Cosmological Singularity in Higher-Order Gravity

We study the stability of the isotropic vacuum Friedmann universe in gravity theories with higher-order curvature terms of the form $(R_{ab}R^{ab})^{n}$ added to the Einstein-Hilbert Lagrangian of general relativity on approach to an initial cosmological singularity. Earlier, we had shown that, when $$, a special isotropic vacuum solution exists which behaves like the radiation-dominated Friedmann universe and is stable to anisotropic and small inhomogeneous perturbations of scalar, vector and tensor type. This is completely different to the situation that holds in general relativity, where an isotropic initial cosmological singularity is unstable in vacuum and under a wide range of non-vacuum conditions. We show that when $n\neq 1$, although a special isotropic vacuum solution found by Clifton and Barrow always exists, it is no longer stable when the initial singularity is approached. We find the particular stability conditions under the influence of tensor, vector, and scalar perturbations for general $n$ for both solution branches. On approach to the initial singularity, the isotropic vacuum solution with scale factor $a(t)=t^{P_{-}/3}$ is found to be stable to tensor perturbations for $0.5<n< 1.1309$ and stable to vector perturbations for $0.861425 < n \leq 1$, but is unstable as $t \to 0$ otherwise. The solution with scale factor $a(t)=t^{P_{+}/3}$ is not relevant to the case of an initial singularity for $n>1$ and is unstable as $t \to 0$ for all $n$ for each type of perturbation.Comment: 25 page

SuperWIMP Dark Matter Signals from the Early Universe

Cold dark matter may be made of superweakly-interacting massive particles, superWIMPs, that naturally inherit the desired relic density from late decays of metastable WIMPs. Well-motivated examples are weak-scale gravitinos in supergravity and Kaluza-Klein gravitons from extra dimensions. These particles are impossible to detect in all dark matter experiments. We find, however, that superWIMP dark matter may be discovered through cosmological signatures from the early universe. In particular, superWIMP dark matter has observable consequences for Big Bang nucleosynthesis and the cosmic microwave background (CMB), and may explain the observed underabundance of 7Li without upsetting the concordance between deuterium and CMB baryometers. We discuss implications for future probes of CMB black body distortions and collider searches for new particles. In the course of this study, we also present a model-independent analysis of entropy production from late-decaying particles in light of WMAP data.Comment: 19 pages, 5 figures, typos correcte

Focus Points and Naturalness in Supersymmetry

We analyze focus points in supersymmetric theories, where a parameter's renormalization group trajectories meet for a family of ultraviolet boundary conditions. We show that in a class of models including minimal supergravity, the up-type Higgs mass has a focus point at the weak scale, where its value is highly insensitive to the universal scalar mass. As a result, scalar masses as large as 2 to 3 TeV are consistent with naturalness, and {\em all} squarks, sleptons and heavy Higgs scalars may be beyond the discovery reaches of the Large Hadron Collider and proposed linear colliders. Gaugino and Higgsino masses are, however, still constrained to be near the weak scale. The focus point behavior is remarkably robust, holding for both moderate and large \tan\beta, any weak scale gaugino masses and A parameters, variations in the top quark mass within experimental bounds, and for large variations in the boundary condition scale.Comment: 30 pages, 17 figure

Electroweak Symmetry Breaking in the DSSM

We study the theoretical and phenomenological consequences of modifying the Kahler potential of the MSSM two Higgs doublet sector. Such modifications naturally arise when the Higgs sector mixes with a quasi-hidden conformal sector, as in some F-theory GUT models. In the Delta-deformed Supersymmetric Standard Model (DSSM), the Higgs fields are operators with non-trivial scaling dimension 1 < Delta < 2. The Kahler metric is singular at the origin of field space due to the presence of quasi-hidden sector states which get their mass from the Higgs vevs. The presence of these extra states leads to the fact that even as Delta approaches 1, the DSSM does not reduce to the MSSM. In particular, the Higgs can naturally be heavier than the W- and Z-bosons. Perturbative gauge coupling unification, a large top quark Yukawa, and consistency with precision electroweak can all be maintained for Delta close to unity. Moreover, such values of Delta can naturally be obtained in string-motivated constructions. The quasi-hidden sector generically contains states charged under SU(5)_GUT as well as gauge singlets, leading to a rich, albeit model-dependent, collider phenomenology.Comment: v3: 40 pages, 3 figures, references added, typos correcte

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

Introduction: Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs. The anti-trypanosomal compound, 3-(oxazolo[4,5-b]pyridine-2-yl)anilide (OXPA), was initially identified in a phenotypic screen and subsequently optimized by structure–activity directed medicinal chemistry. It has been shown to be non-toxic and to be active against a number of trypanosomatid parasites. However, nothing is known about its mechanism of action. Objective: Here, we have utilized an untargeted metabolomics approach to investigate the biochemical effects and potential mode of action of this compound in T. brucei. Methods: Total metabolite extracts were analysed by HILIC-chromatography coupled to high resolution mass spectrometry. Results: Significant accumulation of ceramides was observed in OXPA-treated T. brucei. To further understand drug-induced changes in lipid metabolism, a lipidomics method was developed which enables the measurement of hundreds of lipids with high throughput and precision. The application of this LC–MS based approach to cultured bloodstream-form T. brucei putatively identified over 500 lipids in the parasite including glycerophospholipids, sphingolipids and fatty acyls, and confirmed the OXPA-induced accumulation of ceramides. Labelling with BODIPY-ceramide further confirmed the ceramide accumulation following drug treatment. Conclusion: These findings clearly demonstrate perturbation of ceramide metabolism by OXPA and indicate that the sphingolipid pathway is a promising drug target in T. brucei.No Full Tex

Double Parton Scattering Singularity in One-Loop Integrals

We present a detailed study of the double parton scattering (DPS) singularity, which is a specific type of Landau singularity that can occur in certain one-loop graphs in theories with massless particles. A simple formula for the DPS singular part of a four-point diagram with arbitrary internal/external particles is derived in terms of the transverse momentum integral of a product of light cone wavefunctions with tree-level matrix elements. This is used to reproduce and explain some results for DPS singularities in box integrals that have been obtained using traditional loop integration techniques. The formula can be straightforwardly generalised to calculate the DPS singularity in loops with an arbitrary number of external particles. We use the generalised version to explain why the specific MHV and NMHV six-photon amplitudes often studied by the NLO multileg community are not divergent at the DPS singular point, and point out that whilst all NMHV amplitudes are always finite, certain MHV amplitudes do contain a DPS divergence. It is shown that our framework for calculating DPS divergences in loop diagrams is entirely consistent with the `two-parton GPD' framework of Diehl and Schafer for calculating proton-proton DPS cross sections, but is inconsistent with the `double PDF' framework of Snigirev.Comment: 29 pages, 8 figures. Minor corrections and clarifications added. Version accepted for publication in JHE

Graviton Cosmology in Universal Extra Dimensions

In models of universal extra dimensions, gravity and all standard model fields propagate in the extra dimensions. Previous studies of such models have concentrated on the Kaluza-Klein (KK) partners of standard model particles. Here we determine the properties of the KK gravitons and explore their cosmological implications. We find the lifetimes of decays to KK gravitons, of relevance for the viability of KK gravitons as dark matter. We then discuss the primordial production of KK gravitons after reheating. The existence of a tower of KK graviton states makes such production extremely efficient: for reheat temperature T_RH and d extra dimensions, the energy density stored in gravitons scales as T_RH^{2+3d/2}. Overclosure and Big Bang nucleosynthesis therefore stringently constrain T_RH in all universal extra dimension scenarios. At the same time, there is a window of reheat temperatures low enough to avoid these constraints and high enough to generate the desired thermal relic density for KK WIMP and superWIMP dark matter.Comment: 19 pages, 1 figur

Signatures of multi-TeV scale particles in supersymmetric theories

Supersymmetric particles at the multi-TeV scale will escape direct detection at planned future colliders. However, such particles induce non-decoupling corrections in processes involving the accessible superparticles through violations of the supersymmetric equivalence between gauge boson and gaugino couplings. In a previous study, we parametrized these violations in terms of super-oblique parameters and found significant deviations in well-motivated models. Here, we systematically classify the possible experimental probes of such deviations, and present detailed investigations of representative observables available at a future linear collider. In some scenarios, the $e^-e^-$ option and adjustable beam energy are exploited to achieve high precision. It is shown that precision measurements are possible for each of the three coupling relations, leading to significant bounds on the masses and properties of heavy superparticles and possible exotic sectors.Comment: 37 pages including 17 figures, REVTe