Continuously Accelerating Research

Science is facing a software reproducibility crisis. Software powers experimentation, and fuels insights, yielding new scientific contributions. Yet, the research software is often difficult for other researchers to reproducibly run. Beyond reproduction, research software that is truly reusable will speed science by allowing other researchers to easily build upon and extend prior work. As software engineering researchers, we believe that it is our duty to create tools and processes that instill reproducibility, reusability, and extensibility into research software. This paper outlines a vision for a community infrastructure that will bring the benefits of continuous integration to scientists developing research software. To persuade researchers to adopt this infrastructure, we will appeal to their self-interest by making it easier for them to develop and evaluate research prototypes. Building better research software is a complex socio-technical problem that requires stakeholders to join forces to solve this problem for the software engineering community, and the greater scientific community. This vision paper outlines an agenda for realizing a world where the reproducibility and reusability barriers in research software are lifted, continuously accelerating research

Echocardiographic assessment and percutaneous closure of multiple atrial septal defects

Atrial septal defect closure is now routinely performed using a percutaneous approach under echocardiographic guidance. Centrally located, secundum defects are ideal for device closure but there is considerable morphological variation in size and location of the defects. A small proportion of atrial septal defects may have multiple fenestrations and these are often considered unsuitable for device closure. We report three cases of multiple atrial septal defects successfully closed with two Amplatzer septal occluders

Flecainide overdose – support using an intra-aortic balloon pump

BACKGROUND: Flecainide is an antiarrhythmic agent which is being used increasingly for the management of super-ventricular arrhythmias. Overdose with flecainide is frequently fatal with mortality reported as high as 22% due to arrhythmias, myocardial depression and conduction defects leading to electro-mechanical dissociation and asytole. Supportive measures are often required during the case and previously have included inotropes, extracorporeal membrane oxygenation and cardiopulmonary bypass. CASE PRESENTATION: A 47 year old lady presented to the emergency department with a four hour history of severe central chest pain. Her ECG showed atrial fibrillation and broad QRS complexes with a sine wave appearance. She had a past history of paroxysmal atrial fibrillation and significant psychiatric history. Following thrombolysis for a presumed myocardial infarction she developed cardiogenic shock with severely impaired left ventricular function. An intra-aortic balloon pump was inserted and coronary angiography demonstrated normal coronary arteries. With inotropic support she improved over 48 hours, with both her QRS duration and left ventricular function returning to normal. Biochemical testing following her discharge demonstrated significantly elevated levels of flecainide. CONCLUSION: The use of an intra-aortic balloon pump is a useful supportive measure during the acute phase of flecainide overdose associated with severe myocardial depression

Advice on assistance and protection from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons : Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents

The Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) has provided advice in relation to the Chemical Weapons Convention on assistance and protection. We present the SAB’s response to a request from the OPCW Director-General in 2014 for information on the best practices for preventing and treating the health effects from acute, prolonged, and repeated organophosphorus nerve agent (NA) exposure. The report summarises pre- and post-exposure treatments, and developments in decontaminants and adsorbing materials, that at the time of the advice, were available for NAs. The updated information provided could assist medics and emergency responders unfamiliar with treatment and decontamination options related to exposure to NAs. The SAB recommended that developments in research on medical countermeasures and decontaminants for NAs should be monitored by the OPCW, and used in assistance and protection training courses and workshops organised through its capacity building programmes.Peer reviewe

Traditional and industrial approaches to oil palm cultivation alter the biodiversity of ground-dwelling arthropods in Liberia (West Africa)

Oil palm cultivation is vital to global food security and economically important to farmers. However, the rapid expansion of oil palm plantations has caused large-scale deforestation in the tropics and, consequently, biodiversity loss and changes in ecosystem functioning. Oil palm is primarily cultivated in Southeast Asia, where the ecological impacts of production have been studied extensively. It is also grown in West Africa, using traditional and industrial methods of cultivation. However, in comparison to Southeast Asia, relatively little research on the impacts of oil palm cultivation in West Africa has occurred. Working in the framework of the Sustainable Oil Palm in West Africa (SOPWA) Project (Sinoe County, Liberia), we investigated differences in the biodiversity of ground-dwelling arthropods across rainforest (the regional natural habitat) and oil palm systems cultivated under traditional (called “country palm”) and industrial management. We sampled arthropods with pitfall traps (160 retrieved) across 54 monitoring plots in rainforest, country palm, and industrial oil palm. We found no differences in total arthropod abundance across systems, but we did find changes in arthropod order-level community composition, driven by differences in the relative abundance of Araneae, Collembola, Dermaptera, and Diptera. We conducted focused morphospecies-level analyses on spiders, owing to their key roles as predators within tropical agricultural systems, and to determine if our order-level findings held true at increased taxonomic resolution. Our spider analyses indicated that country palm supported the greatest number of spider individuals and species, and that all systems supported distinct spider assemblages. Our findings have implications for both arthropod conservation and oil palm productivity, owing to the important ecosystem functions (e.g., pest control) that many arthropods provide. Future research should investigate whether changes in on-farm management practices influence arthropod communities – and the ecosystem functions they support – in West Africa

Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on riot control agents in connection to the Chemical Weapons Convention

Compounds that cause powerful sensory irritation to humans were reviewed by the Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) in response to requests in 2014 and 2017 by the OPCW Director-General to advise which riot control agents (RCAs) might be subject to declaration under the Chemical Weapons Convention (the Convention). The chemical and toxicological properties of 60 chemicals identified from a survey by the OPCW of RCAs that had been researched or were available for purchase, and additional chemicals recognised by the SAB as having potential RCA applications, were considered. Only 17 of the 60 chemicals met the definition of a RCA under the Convention. These findings were provided to the States Parties of the Convention to inform the implementation of obligations pertaining to RCAs under this international chemical disarmament and non-proliferation treaty.Peer reviewe

The Freshwater Sounds Archive

AbstractFreshwater ecosystems are full of underwater sounds produced by amphibians, aquatic arthropods, reptiles, plants, fishes, and methane bubbles escaping from the sediment. Although much headway has been made in recent years investigating the overall soundscapes of various freshwater ecosystems around the world, there remains a significant knowledge gap in our collective inability to accurately and reliably link recorded sounds with the species that produced them. Here, we present The Freshwater Sounds Archive, a new global initiative, which seeks to address this knowledge gap by collating species-specific freshwater sound recordings into a publicly available database. By means of metadata collection, we also present a snapshot of the species studied, the recording equipment, and recording parameters used by freshwater ecoacousticians globally. In total, 61 entries were submitted to the archive between the 4th of March 2023 and the 30th of April 2025, representing 16 countries and 6 continents. The most numerous taxonomic group was arthropods (29 entries), followed by fishes (14 entries), amphibians (10 entries), macrophytes (7 entries), and a freshwater mollusk (1 entry). The majority of the submissions were from European countries (27 entries), of which the United Kingdom was the most represented with 14 entries. The next most represented region was North America (11 entries), followed by South America (8 entries), Oceania and Asia (5 entries each), Africa (3 entries), and the Middle East and Central America with 1 entry each. The global south, polar regions, and areas with an elevation &gt;500 m (asl) were underrepresented. The field of freshwater ecoacoustics to date has largely focused on the analysis of ‘sound types’ due to a current lack of knowledge of species-specific sounds. The Freshwater Sounds Archive presents an opportunity to move beyond the ‘sound type’ approach, and towards an approach with higher taxonomic resolution, ultimately resulting in species-specific descriptions. Furthermore, The Freshwater Sounds Archive will provide freshwater ecoacousticians with one of the main tools required to start creating annotated training datasets for machine learning models from soundscape recordings by referring to known species sounds present in the archive. In the long-term, this will result in the automatic detection and classification of species-specific freshwater sounds from soundscape recordings, such as indicator, invasive, and endangered species.</jats:p

The socioecological benefits and consequences of oil palm cultivation in its native range: the sustainable oil palm in West Africa (SOPWA) project

Agriculture is expanding rapidly across the tropics. While cultivation can boost socioeconomic conditions and food security, it also threatens native ecosystems. Oil palm (Elaeis guineensis), which is grown pantropically, is the most productive vegetable oil crop worldwide. The impacts of oil palm cultivation have been studied extensively in Southeast Asia and – to a lesser extent – in Latin America but, in comparison, very little is known about its impacts in Africa: oil palm's native range, and where cultivation is expanding rapidly. In this paper, we introduce a large-scale research programme – the Sustainable Oil Palm in West Africa (SOPWA) Project – that is evaluating the relative ecological impacts of oil palm cultivation under traditional (i.e., by local people) and industrial (i.e., by a large-scale corporation) management in Liberia. Our paper is twofold in focus. First, we use systematic mapping to appraise the literature on oil palm research in an African context, assessing the geographic and disciplinary focus of existing research. We found 757 publications occurring in 36 African countries. Studies tended to focus on the impacts of palm oil consumption on human health and wellbeing. We found no research that has evaluated the whole-ecosystem (i.e., multiple taxa and ecosystem functions) impacts of oil palm cultivation in Africa, a knowledge gap which the SOPWA Project directly addresses. Second, we describe the SOPWA Project's study design and—using canopy cover, ground vegetation cover, and soil temperature data as a case study—demonstrate its utility for assessing differences between areas of rainforest and oil palm agriculture. We outline the socioecological data collected by the SOPWA Project to date and describe the potential for future research, to encourage new collaborations and additional similar projects of its kind in West Africa. Increased research in Africa is needed urgently to understand the combined ecological and sociocultural impacts of oil palm and other agriculture in this unique region. This will help to ensure long-term sustainability of the oil palm industry—and, indeed, all tropical agricultural activity—in Africa