What format of treatment do patients with emotional disorders prefer and why? Implications for public mental health settings and policies

Objective We analyzed the preference of three psychological intervention formats—individual, group, and online—in a sample of 267 patients with a primary diagnosis of emotional disorder in Spanish public mental health settings. Method We studied patients’ preferences considering sociodemographic characteristics, diagnoses, history of psychological treatments, number of sessions, and satisfaction with past interventions. Results Most participants (85.4%) preferred psychological treatment in an individual format, 14.2% in group, and 0.4% online. When comparing the people who chose individual and group treatment, no demographic or clinical differences were found. The arguments against group format were the lack of privacy and expression difficulties. Regarding online format, these included being considered impersonal and ineffective. Conclusion The rejection of group and online psychotherapy formats allows us to define the actions we should carry out in public mental health settings to improve the acceptance of more costeffective therapy formats

Genetic and genomic insights into age at natural menopause

The age at natural menopause shows great variability. It has been proposed that early age at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later age at menopause is a risk factor for breast cancer. In addition, it is thought that the genetic factors accounting for the genetic variability in age at menopause could also play a role in those diseases, as well as infertility in women. In this minireview we comment on the latest genetics and genomics insights into age at natural menopause

Promoter sequence of Shiga Toxin II (Stx2) is recognized in vivo leading to the production of biologically active Stx2

Shiga toxins (Stxs) are the main agent responsible for the development of hemolytic uremic syndrome (HUS), the most severe and life-threatening systemic complication of infection with enterohemorrhagic Escherichia coli (EHEC) strains. We previously reported Stx2 expression by eukaryotic cells after they were transfected in vitro with the stx2 gene cloned into a prokaryotic plasmid (pStx2). The aim of this study was to evaluate whether mammalian cells were also able to express Stx2 in vivo after pStx2 injection. Mice were inoculated by hydrodynamic based transfection (HBT) with pStx2. We studied the survival, the percentage of polymorphonuclear leukocytes in plasma, plasma urea levels and histology of the kidney and the brain of mice. Mice displayed a lethal dose-response to pStx2. Stx2-mRNA was recovered from the liver and Stx2 cytotoxic activity was observed in plasma of mice injected with pStx2. Stx2 was detected by immunofluorescence in the brains of mice inoculated with pStx2, and markers of central nervous system (CNS) damage were observed, including increased expression of glial fibrillary acidic protein (GFAP) and fragmentation of NeuN in neurons. Moreover, anti-Stx2B immunized mice were protected against pStx2 inoculation. Our results show that Stx2 is expressed in vivo from the wild stx2 gene, reproducing pathogenic damage induced by purified Stx2 or secondary to EHEC-infection.Fil: Bentancor, Leticia Veronica. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; ArgentinaFil: Mejias, Maria Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; ArgentinaFil: Pinto, Alípio. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Bilen, Marcos Fabian. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; ArgentinaFil: Meiss, Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; ArgentinaFil: Rodriguez Galan, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Baez, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Pedrotti, Luciano Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Goldstein Raij, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; ArgentinaFil: Ghiringhelli, Pablo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; ArgentinaFil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentin

Afectación de los aspectos económicos patrimoniales en la evaluación de la liquidación de la sociedad de gananciales en Huancayo 2021

La investigación partió del problema: ¿Cómo se afecta los aspectos económicos y patrimoniales en la evaluación de “la liquidación de la sociedad de gananciales” en Huancayo 2021?; siendo el objetivo Explicar Cómo se afecta los aspectos económicos y patrimoniales en la evaluación de la liquidación de la sociedad de gananciales en Huancayo 2021. “Esta publicación se asienta como el tipo de investigación teórica o básica, en el nivel explicativo; para comparar la hipótesis se manejó el método General es decir el analítico – sintético, como métodos particulares se empleó el exegético, con un diseño no experimental transeccional, con una sola muestra, en la recolección de datos se valieron del análisis documental y la encuesta, como resultado se obtuvo la aceptación de la hipótesis planteada por el investigador mediante la prueba estadística X2 (chi cuadrado) llegando a la conclusión Los aspectos económicos y patrimoniales se afectan significativamente en la evaluación de la liquidación de la sociedad de gananciales en Huancayo 2021, generando la recomendación A los operadores jurídicos se recomienda promover el pago de recompensa, ya que es una figura jurídica poco usada en nuestro sistema jurídico en materia familia”

Yersinia pseudotuberculosis Spatially Controls Activation and Misregulation of Host Cell Rac1

Yersinia pseudotuberculosis binds host cells and modulates the mammalian Rac1 guanosine triphosphatase (GTPase) at two levels. Activation of Rac1 results from integrin receptor engagement, while misregulation is promoted by translocation of YopE and YopT proteins into target cells. Little is known regarding how these various factors interplay to control Rac1 dynamics. To investigate these competing processes, the localization of Rac1 activation was imaged microscopically using fluorescence resonance energy transfer. In the absence of translocated effectors, bacteria induced activation of the GTPase at the site of bacterial binding. In contrast, the entire cellular pool of Rac1 was inactivated shortly after translocation of YopE RhoGAP. Inactivation required membrane localization of Rac1. The translocated protease YopT had very different effects on Rac1. This protein, which removes the membrane localization site of Rac1, did not inactivate Rac1, but promoted entry of cleaved activated Rac1 molecules into the host cell nucleus, allowing Rac1 to localize with nuclear guanosine nucleotide exchange factors. As was true for YopE, membrane-associated Rac1 was the target for YopT, indicating that the two translocated effectors may compete for the same pool of target protein. Consistent with the observation that YopE inactivation requires membrane localization of Rac1, the presence of YopT in the cell interfered with the action of the YopE RhoGAP. As a result, interaction of target cells with a strain that produces both YopT and YopE resulted in two spatially distinct pools of Rac1: an inactive cytoplasmic pool and an activated nuclear pool. These studies demonstrate that competition between bacterial virulence factors for access to host substrates is controlled by the spatial arrangement of a target protein. In turn, the combined effects of translocated bacterial proteins are to generate pools of a single signaling molecule with distinct localization and activation states in a single cell

Validación lingüística y psicométrica del cuestionario “The princess margaret hospital satisfaction with doctor questionnaire” en pacientes oncológicos

31 PáginasObjetivos: Realizar la validación Lingüística y Psicométrica del cuestionario “The Princess Margaret Hospital Satisfaction with Doctor Questionnaire” en Pacientes Oncológicos. Metodología: Estudio Prospectivo con un Diseño de Validación de Escalas. Población: Pacientes Oncológicos que asisten a consulta externa de las especialidades Oncológicas en la Fundación Cardio Infantil (en Bogotá) y el Hospital Pablo Tobón Uribe (en Medellín). Procedimiento: Validación Lingüística: Posterior a creación del comité de revisión, se realizara traducción y re-traducción por peritos bilingües, realizando homogeneización conceptual y semántica, el formato preliminar se avalara por prueba piloto donde se evaluaran particularidades y su comprensión para definir una versión definitiva. Validación Psicométrica: Se realizara validez de apariencia y de contenido por un grupo focal de expertos, y de constructo por análisis factorial. Se valorara su consistencia interna (alfa de Cronbach), y su validez convergente (Coeficiente de correlación de Spearman); se analizara su confiabilidad test – re test y la correlación inter evaluador (ambos con el Coeficiente de correlación de Spearman); por último, analizaremos la detección de cambios clínicos importantes (Test de U Mann Whitney). Utilidad: Se medirá según el tiempo medio utilizado para la aplicación de la escala, se describirán las necesidades particulares para su ejecución, y el grado necesario de capacitación; al final: se describirá la forma, método y tiempo para la generación de la calificación final

Col·leccions singulars a les biblioteques de la Universitat Autònoma de Barcelona

Les biblioteques de la Universitat Autònoma de Barcelona són, com la mateixa institució, entitats amb una història curta; però, malgrat que van començar la seva activitat fa menys de cinquanta anys, els seus fons han assolit una importància considerable i superen en quantitat els de moltes universitats centenàries del nostre context. Les col·leccions de fons antics de les biblioteques de la UAB són, per aquesta mateixa raó, limitades, si bé se n'han anat creant algunes d'especialitzades d'importància i valor singulars. Aquest llibre pretén donar-les a conèixer al món universitari, però també al públic en general. Moltes són col·leccions úniques, fruit del treball persistent del personal bibliotecari, del professorat i de la generositat de moltes persones particulars, que han donat o llegat a la nostra universitat els seus arxius, les seves biblioteques personals o les seves col·leccions especialitzades. Aquestes col·leccions comprenen molts àmbits de les ciències i de les humanitats i, molt sovint, es tracta de col·leccions úniques al nostre país. Hi trobareu també un ampli ventall de tipologies documentals en llengües diverses, des dels mapes fins als audiovisuals, des de les revistes i diaris fins als cartells, des dels fons antics fins als més actuals, arxius personals i fons institucionals. Les biblioteques de la Universitat, a més d'inventariar i catalogar aquests fons documentals, també porten a terme una tasca constant de preservació i difusió, que sovint inclou la digitalització dels documents, que després es posen a l'abast del públic general mitjançant el dipòsit digital institucional (ddd.uab.cat)

Reduced Order Modelling for the Optimization of CSP Tower Receivers and Their Cavities for High Temperature Applications

We present a Reduced Order Method approach to the heat exchange and loses in a simulated 3D cavity of CSP tower receivers. We validate the method in a 2D Boussinesq model problem for natural convection monitoring temperature, pressure and velocity for different values of the Rayleigh number. For the 3D problem of heat loses estimation we compute the snapshots with Ansys Fluent in a realistic model of a cavity with wind velocity and wall temperatures as varying parameters. The reduction in computational time can be up to four orders of magnitude with relative errors of 10^-5

Number of prior episodes and the presence of depressive symptoms are associated with longer length of stay for patients with acute manic episodes

<p>Abstract</p> <p>Background</p> <p>Few studies have analyzed predictors of length of stay (LOS) in patients admitted due to acute bipolar manic episodes. The purpose of the present study was to estimate LOS and to determine the potential sociodemographic and clinical risk factors associated with a longer hospitalization. Such information could be useful to identify those patients at high risk for long LOS and to allocate them to special treatments, with the aim of optimizing their hospital management.</p> <p>Methods</p> <p>This was a cross-sectional study recruiting adult patients with a diagnosis of bipolar disorder (<it>Diagnostic and Statistical Manual of Mental Disorders</it>, 4th edition, text revision (DSM-IV-TR) criteria) who had been hospitalized due to an acute manic episode with a Young Mania Rating Scale total score greater than 20. Bivariate correlational and multiple linear regression analyses were performed to identify independent predictors of LOS.</p> <p>Results</p> <p>A total of 235 patients from 44 centers were included in the study. The only factors that were significantly associated to LOS in the regression model were the number of previous episodes and the Montgomery-Åsberg Depression Rating Scale (MADRS) total score at admission (<it>P </it>< 0.05).</p> <p>Conclusions</p> <p>Patients with a high number of previous episodes and those with depressive symptoms during mania are more likely to stay longer in hospital. Patients with severe depressive symptoms may have a more severe or treatment-resistant course of the acute bipolar manic episode.</p

Cardioprotective effect of the short-acting beta-blocker esmolol in experimental ischemia/reperfusion.

This study was funded by a grant from the Spanish Society of Cardiology “Investigación Traslacional 2017”. J.N. is a recipient of a predoctoral grant “Jordi Soler Soler” from the CIBERCV. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence.S