Ethical evaluation of audience segmentation in social marketing

Purpose – The ethicality of using audience segmentation in social marketing contexts has typically been framed within either a consequentialist or non-consequentialist perspective, leading to a hitherto intractable debate. This paper seeks to shed new light on this debate using two alternative ethical frameworks: the theory of just health care (TJHC) and integrative social contracts theory (ISCT). Design/methodology/approach – The paper uses cross-sectional survey data from a Kenyan social marketing campaign that aimed to increase awareness and support for the use of anti-retroviral therapy (ART), a class of drugs that inhibit the development of HIV. Findings – Application of the TJHC and ISCT to the Kenyan social marketing campaign revealed the use of audience segmentation to be ethically justified. Moreover, the TJHC provided a useful framework for guiding decisions about the selection of target audience(s) in health-related contexts. Practical implications – In situations where there are known asymmetries in exposure to mass media channels, adopting a non-segmented mass-media approach may unintentionally entrench pre-existing disparities in health knowledge. Originality/value – The application of the TJHC and ISCT to health-related social marketing contexts offers a means of resolving the longstanding debate about the ethicality of audience segmentation. The ethical principles underpinning the TJHC also provide a decision-making framework to guide discussions about whether audience segmentation should be based on cost-effectiveness (consequentialism) or need (non-consequentialism). This is particularly relevant in social marketing settings, where the resources available for conducting campaigns are often limited and segmentation decisions about the groups that are targeted or excluded can have important health-related implications. </jats:sec

Evaluating the efficacy of tuberculosis advocacy, communication and social mobilization (ACSM) activities in Pakistan : a cross-sectional study

BACKGROUND: Tuberculosis (TB) continues to be a major public health and development problem within many low- and middle-income countries. Although Advocacy, Communication and Social Mobilization (ACSM) activities have been undertaken in high TB burden countries to remediate these issues, there is little empirical evidence of the efficacy of these approaches. The purpose of this study was therefore to examine the efficacy of an ACSM program undertaken within Pakistan. Pakistan was chosen because it has received considerable funding for ACSM related activities and is one of 22 high-burden TB countries. METHODS: The program was evaluated by surveying a stratified random sample of 2,400 participants across 57 districts of Pakistan. Participants were categorized into one of three groups: aware of both media and community ACSM activities (Aware(Media)&(Community)), aware of ACSM media activities only (Aware(Media)), or unaware of any ACSM activities (Unaware(Media)&(Community)). RESULTS: Independent measures ANCOVA revealed complex differences in knowledge, attitudes, and intended behaviors towards TB between the three groups. In general, Unaware(Media)&(Community) cases had a poorer understanding of TB and its treatment, whilst awareness of ACSM activities was highest among literate and urban dwelling Pakistanis. Preferred sources of TB information were also found to vary by gender, geographic location, and literacy. CONCLUSIONS: Whilst highlighting improvements in knowledge and attitudes toward TB, the results also provide invaluable insights into areas where further work needs to be done to address deficits in TB understanding, particularly among rural and illiterate Pakistanis. Equally important, the findings have implications for future TB ACSM initiatives in Pakistan in terms of leveraging the preferred media channels of key demographic segments and exploring the degree to which exposure to multiple channels of communication may have an additive effect on health knowledge

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.

Inflammation is an essential aspect of innate immunity but also contributes to diverse human diseases. Although much is known about the kinases that control inflammatory signaling, less is known about the opposing phosphatases. Here we report that deletion of the gene encoding PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) protects mice from lethal lipopolysaccharide (LPS) challenge and live Escherichia coli infection. Investigation of PHLPP1 function in macrophages reveals that it controls the magnitude and duration of inflammatory signaling by dephosphorylating the transcription factor STAT1 on Ser727 to inhibit its activity, reduce its promoter residency, and reduce the expression of target genes involved in innate immunity and cytokine signaling. This previously undescribed function of PHLPP1 depends on a bipartite nuclear localization signal in its unique N-terminal extension. Our data support a model in which nuclear PHLPP1 dephosphorylates STAT1 to control the magnitude and duration of inflammatory signaling in macrophages

Is There a Fundamental Line for Disk Galaxies?

We show that there are strong local correlations between metallicity, surface brightness, and dynamical mass-to-light ratio within M33, analogous to the fundamental line of dwarf galaxies identified by Prada & Burkert (2002). Using near-infrared imaging from 2MASS, the published rotation curve of M33, and literature measurements of the metallicities of HII regions and supergiant stars, we demonstrate that these correlations hold for points at radial distances between 140 pc and 6.2 kpc from the center of the galaxy. At a given metallicity or surface brightness, M33 has a mass-to-light ratio approximately four times as large as the Local Group dwarf galaxies; other than this constant offset, we see broad agreement between the M33 and dwarf galaxy data. We use analytical arguments to show that at least two of the three fundamental line correlations are basic properties of disk galaxies that can be derived from very general assumptions. We investigate the effect of supernova feedback on the fundamental line with numerical models and conclude that while feedback clearly controls the scatter in the fundamental line, it is not needed to create the fundamental line itself, in agreement with our analytical calculations. We also compare the M33 data with measurements of a simulated disk galaxy, finding that the simulation reproduces the trends in the data correctly and matches the fundamental line, although the metallicity of the simulated galaxy is too high, and the surface brightness is lower than that of M33.Comment: 14 pages, 14 figures (5 in color). Accepted for publication in Ap

The Response to a Perturbation in the Reflection Amplitude

We apply inverse scattering theory to calculate the functional derivative of the potential $V(x)$ and wave function $\psi(x,k)$ of a one-dimensional Schr\"odinger operator with respect to the reflection amplitude $r(k)$.Comment: 16 pages, no figure

Characterizing K2 Candidate Planetary Systems Orbiting Low-mass Stars. I. Classifying Low-mass Host Stars Observed during Campaigns 1–7

We present near-infrared spectra for 144 candidate planetary systems identified during Campaigns 1–7 of the NASA K2 Mission. The goal of the survey was to characterize planets orbiting low-mass stars, but our Infrared Telescope Facility/SpeX and Palomar/TripleSpec spectroscopic observations revealed that 49% of our targets were actually giant stars or hotter dwarfs reddened by interstellar extinction. For the 72 stars with spectra consistent with classification as cool dwarfs (spectral types K3–M4), we refined their stellar properties by applying empirical relations based on stars with interferometric radius measurements. Although our revised temperatures are generally consistent with those reported in the Ecliptic Plane Input Catalog (EPIC), our revised stellar radii are typically 0.13 [subscript ⊙](39%) larger than the EPIC values, which were based on model isochrones that have been shown to underestimate the radii of cool dwarfs. Our improved stellar characterizations will enable more efficient prioritization of K2 targets for follow-up studies

TESS Discovery of an ultra-short-period planet around the nearby M dwarf LHS 3844

Data from the newly-commissioned \textit{Transiting Exoplanet Survey Satellite} (TESS) has revealed a "hot Earth" around LHS 3844, an M dwarf located 15 pc away. The planet has a radius of $1.32\pm 0.02$ $R_\oplus$ and orbits the star every 11 hours. Although the existence of an atmosphere around such a strongly irradiated planet is questionable, the star is bright enough ($I=11.9$, $K=9.1$) for this possibility to be investigated with transit and occultation spectroscopy. The star's brightness and the planet's short period will also facilitate the measurement of the planet's mass through Doppler spectroscopy.Comment: 10 pages, 4 figures. Submitted to ApJ Letters. This letter makes use of the TESS Alert data, which is currently in a beta test phase, using data from the pipelines at the TESS Science Office and at the TESS Science Processing Operations Cente

Characterizing K2 Candidate Planetary Systems Orbiting Low-Mass Stars II: Planetary Systems Observed During Campaigns 1-7

We recently used near-infrared spectroscopy to improve the characterization of 76 low-mass stars around which K2 had detected 79 candidate transiting planets. 29 of these worlds were new discoveries that had not previously been published. We calculate the false positive probabilities that the transit-like signals are actually caused by non-planetary astrophysical phenomena and reject five new transit-like events and three previously reported events as false positives. We also statistically validate 17 planets (7 of which were previously unpublished), confirm the earlier validation of 22 planets, and announce 17 newly discovered planet candidates. Revising the properties of the associated planet candidates based on the updated host star characteristics and refitting the transit photometry, we find that our sample contains 21 planets or planet candidates with radii smaller than 1.25 R⊕, 18 super-Earths (1.25–2 R⊕), 21 small Neptunes (2–4 R⊕), three large Neptunes (4–6 R⊕), and eight giant planets (>6 R⊕). Most of these planets are highly irradiated, but EPIC 206209135.04 (K2-72e, 1.29^(+0.14)_(-0.13) R⊕), EPIC 211988320.01 (R_p = 2.86^(+0.16)_(-0.15) R⊕), and EPIC 212690867.01 (2.20^(+0.19)_(-0.18) R⊕) orbit within optimistic habitable zone boundaries set by the "recent Venus" inner limit and the "early Mars" outer limit. In total, our planet sample includes eight moderately irradiated 1.5–3 R⊕ planet candidates (F_p ≾ 20 F⊕) orbiting brighter stars (Ks < 11) that are well-suited for atmospheric investigations with the Hubble, Spitzer, and/or James Webb Space Telescopes. Five validated planets orbit relatively bright stars (Kp < 12.5) and are expected to yield radial velocity semi-amplitudes of at least 2 m s^(−1). Accordingly, they are possible targets for radial velocity mass measurement with current facilities or the upcoming generation of red optical and near-infrared high-precision RV spectrographs