Do medical students want to learn about global health?

Conflicts of interest and funding: We declare that we have no conflicts of interest. A grant from the Partnership of Maternal, Newborn and Child Health funded this studyPeer reviewedPublisher PD

WHOI acoustic telemetry project interim report 12/1/88 - 6/1/89

This interim report covers the progress of the acoustic telemetry project during the period 12/1/88 to 5/15/89. In general, the work followed the format specified in WHOI proposal No. 5674.1. The major exception was the deletion of the transmitter array development task and a corresponding funding decrease from $242,242 to$170,000. In addition, the period for the funding was extended to June 30, partly due to a two month delay in project startup. The telemetry project was centered around the construction, programming and testing of a digital receiver prototype capable of supporting future signal processing algorithms in real-time over ocean acoustic channels. The baseline receiver consists of a two-channel analog quadrature demodulator, and interface to a multiprocessor receiver for digital signal processing. The software developed includes routines for command and control of the analog demodulator, data handling and formatting, and minimal software to digitally implement an incoherent MFSK demodulator, synchronizer and data decoder. Data storage and display programs were also completed to facilitate the performance analysis of the unit during testing. The system was tested in Woods Hole harbor at data rates up to 4800 bits/sec. The acoustic channel was time-dispersive Rayleigh fading, and performance close to theoretical expectations was achieved. We are confident that the system error behavior is arising from channel-caused effects and known deficiencies in system performance, such as excessive synchronizer steady-state jitter.Funding was provided by the Office of Naval Research under contract Number N00014-86-K-0751, and by the Charles Stark Draper Laboratory Inc

Biomarkers of sepsis in neonates and children

Sepsis, and related complications, is still a common cause of death in hospitalized patients worldwide, especially in critically ill neonates and children. Sepsis is also responsible for significant morbidity, and financial burden. It is very important to recognize sepsis early, since delayed diagnosis is associated with worse outcome. The early detection of sepsis remains a great challenge for clinicians because the use of blood cultures, the gold standard for diagnosis of bacteremia, is fraught with difficulties. The role of different immune and metabolic biomarkers is to improve the diagnosis, treatment and prognosis of sepsis. White blood cell count, C-reactive protein and procalcitonin are currently the most widely used biomarkers, but they have limited abilities to distinguish sepsis from other inflammatory conditions or to predict outcome. In this review, these biomarkers will be discussed along with novel diagnostic, prognostic and treatment response biomarkers, including interleukins -6, -8, -18, tumor necrosis factor – alpha, CD11b, CD64 and CD15s. The future of sepsis biomarkers lies in extensive validation studies of all novel biomarkers and their combinations as early predictors of sepsis. Also, research to identify novel sepsis biomarkers and develop specific therapeutic strategies based on biomarker information has to be continued

Neurophysiologic markers of primary motor cortex for laryngeal muscles and premotor cortex in caudal opercular part of inferior frontal gyrus investigated in motor speech disorder : a navigated transcranial magnetic stimulation (TMS) study

Transcranial magnetic stimulation studies have so far reported the results of mapping the primary motor cortex (M1) for hand and tongue muscles in stuttering disorder. This study was designed to evaluate the feasibility of repetitive navigated transcranial magnetic stimulation (rTMS) for locating the M1 for laryngeal muscle and premotor cortical area in the caudal opercular part of inferior frontal gyrus, corresponding to Broca's area in stuttering subjects by applying new methodology for mapping these motor speech areas. Sixteen stuttering and eleven control subjects underwent rTMS motor speech mapping using modified patterned rTMS. The subjects performed visual object naming task during rTMS applied to the (a) left M1 for laryngeal muscles for recording corticobulbar motor-evoked potentials (CoMEP) from cricothyroid muscle and (b) left premotor cortical area in the caudal opercular part of inferior frontal gyrus while recording long latency responses (LLR) from cricothyroid muscle. The latency of CoMEP in control subjects was 11.75 +/- A 2.07 ms and CoMEP amplitude was 294.47 +/- A 208.87 A mu V, and in stuttering subjects CoMEP latency was 12.13 +/- A 0.75 ms and 504.64 +/- A 487.93 A mu V CoMEP amplitude. The latency of LLR in control subjects was 52.8 +/- A 8.6 ms and 54.95 +/- A 4.86 in stuttering subjects. No significant differences were found in CoMEP latency, CoMEP amplitude, and LLR latency between stuttering and control-fluent speakers. These results indicate there are probably no differences in stuttering compared to controls in functional anatomy of the pathway used for transmission of information from premotor cortex to the M1 cortices for laryngeal muscle representation and from there via corticobulbar tract to laryngeal muscles.Peer reviewe

A follow-up study of the business administration graduates of the university of New Hampshire

Thesis (Ed.M.)--Boston University This item was digitized by the Internet Archive

Neurophysiologic markers of primary motor cortex for laryngeal muscles and premotor cortex in caudal opercular part of inferior frontal gyrus investigated in motor speech disorder : a navigated transcranial magnetic stimulation (TMS) study

Transcranial magnetic stimulation studies have so far reported the results of mapping the primary motor cortex (M1) for hand and tongue muscles in stuttering disorder. This study was designed to evaluate the feasibility of repetitive navigated transcranial magnetic stimulation (rTMS) for locating the M1 for laryngeal muscle and premotor cortical area in the caudal opercular part of inferior frontal gyrus, corresponding to Broca's area in stuttering subjects by applying new methodology for mapping these motor speech areas. Sixteen stuttering and eleven control subjects underwent rTMS motor speech mapping using modified patterned rTMS. The subjects performed visual object naming task during rTMS applied to the (a) left M1 for laryngeal muscles for recording corticobulbar motor-evoked potentials (CoMEP) from cricothyroid muscle and (b) left premotor cortical area in the caudal opercular part of inferior frontal gyrus while recording long latency responses (LLR) from cricothyroid muscle. The latency of CoMEP in control subjects was 11.75 +/- A 2.07 ms and CoMEP amplitude was 294.47 +/- A 208.87 A mu V, and in stuttering subjects CoMEP latency was 12.13 +/- A 0.75 ms and 504.64 +/- A 487.93 A mu V CoMEP amplitude. The latency of LLR in control subjects was 52.8 +/- A 8.6 ms and 54.95 +/- A 4.86 in stuttering subjects. No significant differences were found in CoMEP latency, CoMEP amplitude, and LLR latency between stuttering and control-fluent speakers. These results indicate there are probably no differences in stuttering compared to controls in functional anatomy of the pathway used for transmission of information from premotor cortex to the M1 cortices for laryngeal muscle representation and from there via corticobulbar tract to laryngeal muscles.Peer reviewe