Malaltia de Kikuchi-Fujimoto: presentació d'un cas pediàtric

Introducció. La malaltia de Kikuchi-Fujimoto, o limfadenitis necrosant histiocítica, és una patologia benigna poc freqüent que es caracteritza per clínica de febre i limfadenopatia cervical. Predomina en noies joves i habitualment s'autolimita entre els 2 i els 4 mesos sense complicacions. Cas clínic. Es presenta el cas d'una pacient de 14 anys que presenta febre de tres dies d'evolució i adenopaties cervicals dretes. Les setmanes prèvies va presentar un quadre febril que es va autolimitar sense poder filiar-ne l'etiologia. S'amplia l'estudi amb proves complementàries, i es descarten amb l'analítica sanguínia i les proves d'imatge les causes infeccioses o tumorals. Es fa exèresi quirúrgica d'una adenopatia cervical amb intenció diagnosticoterapèutica. L'estudi immunohistoquímic presenta característiques típiques de la limfadenitis necrosant histiocítica. La pacient presenta remissió de la simptomatologia i desaparició de les adenopaties. Comentaris. La limfadenitis necrosant histiocítica és una malaltia poc freqüent, però és important tenir-la en compte en pacients joves amb quadre febril i adenopaties de llarga evolució. La biòpsia del gangli per al diagnòstic definitiu és important per evitar altres proves o tractaments més agressius i innecessaris

Dinner du Jour

Kelly and Kristin are two working moms with a shared interest in cooking, baking, and gardening. We’ve been friends since high school, though these days our friendship requires a multitude of e-mails, Skype calls, online chats, and the occasional plane ticket, as Kelly lives in Milwaukee and Kristin has moved abroad to the Irish countryside. After swapping recipes and menus for years, we created this blog to serve as a kind of archive of our food exchanges as well as to inspire others to cook creative, tasty dinners for themselves and their families

The role of phospholipase D1 in trafficking and processing of amyloid precursor protein

Growing evidence indicates that intracellular signaling lipids control the trafficking and processing of amyloid precursor protein (APP) with major implications for pathological and behavioral manifestations associated with Alzheimer's disease (AD). One such lipid is phosphatidic acid (PA), which mediates membrane trafficking and is produced by a variety of enzymes, including phospholipase D (PLD). We previously demonstrated that a PLD isoform, PLD2, is required for the synaptotoxic and memory-impairing actions of amyloid beta in an AD mouse model. The role that the other PLD isoform, PLD1, plays in AD is unclear, although cell culture studies from other groups have suggested it modulates the trafficking of APP and presenilin 1, the catalytic subunit of gamma secretase. Here, we investigate the role of PLD1 in the biology of APP as well as in an AD mouse model. We report that removing PLD1, unlike PLD2, causes a dramatic decrease in brain levels of PA, indicating that PLD1 is a major source of PA in the brain. Additionally, removing PLD1 from primary neurons causes a redistribution of APP from endosomes, a primary station for amyloidogenesis, to the Golgi complex, while PLD1 overexpression produces the converse phenotype. Pld1 null mice harboring familial AD-linked (FAD) APP mutations exhibited decreased brain amyloid and an accumulation of APP COOH-terminal fragments. This finding was particularly evident in Pld1 null membrane rafts, whose lipidome was profoundly altered. Acute inhibition of PLD1 reduced APP processing by gamma secretase, consistent with a regulatory role of the lipid raft environment on gamma secretase, a complex highly active in membrane rafts. Finally, Pld1 nullizygosity rescued cognitive deficits in the transgenic model. Thus, PLD1 and its product PA control the metabolism of APP and emerge as potential drug targets for Alzheimer's disease therapy

Liposclerosing Myxofibrous Tumor of the Cranial Vault

Background and Importance: Liposclerosing myxofibrous tumor (LSMFT) are rare benign fibro-osseous tumors most frequently occurring in the proximal femur. We report the first case of this rare tumor occurring within the calvarium. Clinical Presentation: Our patient presented with a 2-year history of enlarging, painless, fixed mass over the left forehead. She underwent surgical resection and the mass was histologically confirmed to be a liposclerosing myxofibrous tumor. Conclusion: LSMFT is a rare tumor that should remain on the differential for lesions of the calvarium. When diagnosed, this lesion can be removed with the goal of gross total resection and excellent cosmesis can be achieved

Analyse des facteurs de la contamination par les aflatoxines dans la filière arachide aux Nord et Nord-Est d'Haïti

The table of contents for this item can be shared with the requester. The requester may then choose one chapter, up to 10% of the item, as per the Fair Dealing provision of the Canadian Copyright Ac