Texting Sexual Health Pilot - Interview Guide

A semi-structured topic guide used to discover participants’ views, experiences, and recommendations for improvements to behavioral intervention on sexual health. Questions cover tone and frequency of text messages, views regarding the message content, any concerns about others viewing texts, what (if anything) they had learned from text messages, sexual behavior since enrolment (such as condom use and partner notification), and suggested improvements to the intervention

Beyond the ‘Stop Gap’: Young (adult) women’s experiences of living with parents in the aftermath of the Greek austerity crisis

In the context of greater strains imposed by the post-2008 global financial crisis, it has become more commonplace for young people to live with their parents for extended periods. Beyond a domination of Anglophone research, far less is known about whether these experiences of living with parents vary in countries with different economic and cultural contexts. This article focuses on young women in contemporary Greece – a society undergoing radical social restructuring in the wake of the post-2008 economic crisis. Drawing on qualitative interviews with young university-educated women in urban Greece (n=36), the article argues that the current fiscal crisis alongside long-standing patriarchal norms place a significant burden on the lives of these young women. It concludes that evaluation of the impact of financial crisis on the living arrangements of young people should carefully assess the interaction of the gender and cultural aspects of family lives

Coming to Terms with the Greek Crisis: Highly Educated Young Women’s Employment Struggles in Conditions of Economic Austerity

The global financial recession which began in 2008 has led to significant economic and social consequences for youth, with the case of Greece being a notable one in terms of severity. Repeated political-economic ‘shocks’ to the structure of Greek society have manifest in common situations of unemployment and underemployment. Although impacting heavily on the working classes, severe curtailments in medium-high-skilled labour have also been observed among the middle classes as well. Following these contexts, the article examines the experiences of highly educated young women in Greece (n = 36) as they navigate precarious employment within the midst of the Greek economic crisis. It is argued that rather than their educated status offering opportunities to deploy resources to help withstand the crisis, their high education levels create frustrations and barriers towards achieving suitable employment. These perceived mismatches between high education and low status and/or poor-quality work conditions are assessed in the context of research on emerging adulthood

The burden of diabetes mellitus during pregnancy in low- and middle-income countries : a systematic review

Peer reviewedPublisher PD

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition

Navigational cue effects in Alzheimer's disease and posterior cortical atrophy.

OBJECTIVE: Deficits in spatial navigation are characteristic and disabling features of typical Alzheimer's disease (tAD) and posterior cortical atrophy (PCA). Visual cues have been proposed to mitigate such deficits; however, there is currently little empirical evidence for their use. METHODS: The effect of visual cues on visually guided navigation was assessed within a simplified real-world setting in individuals with tAD (n = 10), PCA (n = 8), and healthy controls (n = 12). In a repeated-measures design comprising 36 trials, participants walked to a visible target destination (an open door within a built environment), with or without the presence of an obstacle. Contrast and motion-based cues were evaluated; both aimed to facilitate performance by applying perceptual changes to target destinations without carrying explicit information. The primary outcome was completion time; secondary outcomes were measures of fixation position and walking path directness during consecutive task phases, determined using mobile eyetracking and motion capture methods. RESULTS: Results illustrate marked deficits in patients' navigational ability, with patient groups taking an estimated two to three times longer to reach target destinations than controls and exhibiting tortuous walking paths. There were no significant differences between tAD and PCA task performance. Overall, patients took less time to reach target destinations under cue conditions (contrast-cue: 11.8%; 95% CI: [2.5, 20.3]) and were more likely initially to fixate on targets. INTERPRETATION: The study evaluated navigation to destinations within a real-world environment. There is evidence that introducing perceptual changes to the environment may improve patients' navigational ability