Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)

Background: This study provides a global overview of the management of patients with acute cholecystitis during the initial phase of the COVID-19 pandemic. Methods: CHOLECOVID is an international, multicentre, observational comparative study of patients admitted to hospital with acute cholecystitis during the COVID-19 pandemic. Data on management were collected for a 2-month study interval coincident with the WHO declaration of the SARS-CoV-2 pandemic and compared with an equivalent pre-pandemic time interval. Mediation analysis examined the influence of SARS-COV-2 infection on 30-day mortality. Results: This study collected data on 9783 patients with acute cholecystitis admitted to 247 hospitals across the world. The pandemic was associated with reduced availability of surgical workforce and operating facilities globally, a significant shift to worse severity of disease, and increased use of conservative management. There was a reduction (both absolute and proportionate) in the number of patients undergoing cholecystectomy from 3095 patients (56.2 per cent) pre-pandemic to 1998 patients (46.2 per cent) during the pandemic but there was no difference in 30-day all-cause mortality after cholecystectomy comparing the pre-pandemic interval with the pandemic (13 patients (0.4 per cent) pre-pandemic to 13 patients (0.6 per cent) pandemic; P = 0.355). In mediation analysis, an admission with acute cholecystitis during the pandemic was associated with a non-significant increased risk of death (OR 1.29, 95 per cent c.i. 0.93 to 1.79, P = 0.121). Conclusion: CHOLECOVID provides a unique overview of the treatment of patients with cholecystitis across the globe during the first months of the SARS-CoV-2 pandemic. The study highlights the need for system resilience in retention of elective surgical activity. Cholecystectomy was associated with a low risk of mortality and deferral of treatment results in an increase in avoidable morbidity that represents the non-COVID cost of this pandemic

Decay spectroscopy at the two-proton drip line: radioactivity of the new nuclides 160Os and 156W

The radioactivity of 76160Os84 and 74156W82 that lie at the two-proton drip line have been measured in an experiment performed at the Accelerator Laboratory of the University of Jyväskylä. The 160Os nuclei were produced using fusion-evaporation reactions induced by a beam of 310 MeV 58Ni ions bombarding a 106Cd target. The 160Os ions were separated in flight using the recoil separator MARA and implanted into a double-sided silicon strip detector, which was used to measure their decays. The α decays of the ground state of 160Os (Eα = 7092(15) keV, t1/2 = 97−32+97 μs) and its isomeric state (Eα = 8890(10) keV, t1/2 = 41−9+15 μs) were measured, allowing the excitation energy of the isomer to be determined as 1844(18) keV. These α-decay properties and the excitation energy of the isomer are compared with systematics. The α decays were correlated with subsequent decays to investigate the β decays of the ground state of 156W, revealing that unlike its isotones, both low-lying isomers were populated in its daughter nuclide, 156Ta. An improved value for the half-life of the proton-decaying high-spin isomeric state in 73156Ta83 of 333−22+25 ms was obtained in a separate experiment using the same experimental systems with a 102Pd target. This result was employed to improve the precision of the half-life determined for 156W, which was measured as 157−34+57 ms

Stage, age, and EBV status impact outcomes of plasmablastic lymphoma patients: A clinicopathologic analysis of 61 patients

10.1186/s13045-015-0163-zJournal of Hematology and Oncology816

Decay spectroscopy at the two-proton drip line: Radioactivity of the new nuclides 160Os and 156W

2023 Descuento SCOAP Artículo firmado por 64 autoresThe radioactivity of Os-160(76)84 and W-156(74)82 that lie at the two-proton drip line has been measured in an experiment performed at the Accelerator Laboratory of the University of Jyvaskyla. The Os-160 nuclei were produced using fusion-evaporation reactions induced by a beam of 310 MeV Ni-58 ions bombarding a Cd-106 target. The Os-160 ions were separated in flight using the recoil separator MARA and implanted into a double-sided silicon strip detector, which was used to measure their decays. The.. decays of the ground state of Os-160 (E-alpha = 7092(15) keV, t(1/2) = 97(-32)(+97) mu s) and its isomeric state (E-alpha = 8890(10) keV, t(1/2) = 41(-9)(+15) mu s) were measured, allowing the excitation energy of the isomer to be determined as 1844(18) keV. These alpha-decay properties and the excitation energy of the isomer are compared with systematics. The alpha decays were correlated with subsequent decays to investigate the beta decays of the ground state of W-156, revealing that unlike its isotones, both low-lying isomers were populated in its daughter nuclide, 156Ta. An improved value for the half-life of the proton-decaying high-spin isomeric state in Ta-156(73)83 of 333(-22) (+25) ms was obtained in a separate experiment using the same experimental systems with a Pd-102 target. This result was employed to improve the precision of the half-life determined for W-156, which was measured as 157(-34)(+57) ms.Science and Technology Facilities Council (United Kingdom)European CommissionSlovak Research and Development AgencyVedecka grantova agentura MSVVaS SR a SAVUnited States Department of EnergyResearch Council of FinlandESET Foundation (Slovakia)Depto. de Estructura de la Materia, Física Térmica y ElectrónicaFac. de Ciencias FísicasInstituto de Física de Partículas y del Cosmos (IPARCOS)TRUEpu