Dynamic Analysis and Design of Motorcycle Mounting System Subjected to Road Loads

This paper presents a comprehensive model of a motorcycle mounting system. The model presented herein consists of two main assemblies. The powertrain assembly and the swing-arm assembly are modeled as a six degree of freedom rigid bodies. The two assemblies are connected to each other using a shaft that is usually referred to as the coupler. The connection points on both assemblies are known.Unlike automobiles, motorcycle performance and handling is highly affected by the external disturbance. In addition to minimizing the shaking loads, the mounting system must be set up such that it also minimizes the external disturbance from the environment such as irregularities in the road profile and road bumps. This disturbance can be transmitted through the tire patch to the engine causing it to hit nearby components. The engine movement needs to be minimized due to space limitations surrounding the engine. In order to do so, these transmitted external loads must be minimized by the use of the mounting system. The load minimization process is achieved by selecting the optimum stiffness parameters, location and orientation of the mounting system that are supporting the engine. This goal is achieved by an optimization scheme that guarantees that the transmitted loads are minimized. An investigation will be done to explore the effect of different road profiles on the mount final geometrical shape

Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120

BACKGROUND: Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations inactivated HIV-1, herpesvirus types 1 (HSV-1) and 2 (HSV-2) and the major nonviral sexually transmitted disease (STD) pathogens and were effective in animal models for vaginal infection by HSV-2 and simian immunodeficiency virus. METHODS: Enzyme-linked immunoassays and flow cytometry were used to demonstrate CAP binding to HIV-1 and to define the binding site on the virus envelope. RESULTS: 1) CAP binds to HIV-1 virus particles and to the envelope glycoprotein gp120; 2) this leads to blockade of the gp120 V3 loop and other gp120 sites resulting in diminished reactivity with HIV-1 coreceptors CXCR4 and CCR5; 3) CAP binding to HIV-1 virions impairs their infectivity; 4) these findings apply to both HIV-1 IIIB, an X4 virus, and HIV-1 BaL, an R5 virus. CONCLUSIONS: These results provide support for consideration of CAP as a topical microbicide of choice for prevention of STDs, including HIV-1 infection

Nitrogen uptake and internal recycling in Zostera marina exposed to oyster farming: eelgrass potential as a natural biofilter

Oyster farming in estuaries and coastal lagoons frequently overlaps with the distribution of seagrass meadows, yet there are few studies on how this aquaculture practice affects seagrass physiology. We compared in situ nitrogen uptake and the productivity of Zostera marina shoots growing near off-bottom longlines and at a site not affected by oyster farming in San Quintin Bay, a coastal lagoon in Baja California, Mexico. We used benthic chambers to measure leaf NH4 (+) uptake capacities by pulse labeling with (NH4)-N-15 (+) and plant photosynthesis and respiration. The internal N-15 resorption/recycling was measured in shoots 2 weeks after incubations. The natural isotopic composition of eelgrass tissues and vegetative descriptors were also examined. Plants growing at the oyster farming site showed a higher leaf NH4 (+) uptake rate (33.1 mmol NH4 (+) m(-2) day(-1)) relative to those not exposed to oyster cultures (25.6 mmol NH4 (+) m(-2) day(-1)). We calculated that an eelgrass meadow of 15-16 ha (which represents only about 3-4 % of the subtidal eelgrass meadow cover in the western arm of the lagoon) can potentially incorporate the total amount of NH4 (+) excreted by oysters (similar to 5.2 x 10(6) mmol NH4 (+) day(-1)). This highlights the potential of eelgrass to act as a natural biofilter for the NH4 (+) produced by oyster farming. Shoots exposed to oysters were more efficient in re-utilizing the internal N-15 into the growth of new leaf tissues or to translocate it to belowground tissues. Photosynthetic rates were greater in shoots exposed to oysters, which is consistent with higher NH4 (+) uptake and less negative delta C-13 values. Vegetative production (shoot size, leaf growth) was also higher in these shoots. Aboveground/belowground biomass ratio was lower in eelgrass beds not directly influenced by oyster farms, likely related to the higher investment in belowground biomass to incorporate sedimentary nutrients

EUROMICRO - Context-based personalization of Web services composition and provisioning

This work presents an approach that aims at personalizing Web services composition and provisioning using context. Composition addresses the situation of a user\u27s request that cannot be satisfied by any available service, and thus requires the combination of several Web services. Provisioning focuses on the deployment of Web services according to users\u27 preferences. A Web service is an accessible application that other applications and humans can discover and trigger. Context is the information that characterizes the interactions between humans, applications, and the surrounding environment. Web services are subject to personalization if there is a need of accommodating users\u27 preferences during service performance and outcome delivery. To be able to track personalization in terms of what happened, what is happening, and what might happen three types of context are devised, and they are referred to as user-, Web service-, and resource-context

The adsorption of human recombinant factor VIII in the presence of the nonionic triblock surfactant Pluronic® F-68 at the air-water interface

The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000 ppm. The rate and extent of surface tension depression in these samples was compared to dynamic tensiometry measurements recorded for F-68 solutions in the presence of rFVIII. Surfactants are used in the biopharmaceutical industry to stabilize therapeutic proteins from aggregation and adsorption loss during manufacturing, and this comparison suggested a substantially different mechanism for rFVIII stabilization by F-68 than that consistent with the kinds of surfactants commonly used in downstream processing. In particular, comparative kinetic data were consistent with the notion that with sufficient F-68 in solution, rFVIII did not adsorb at the air-water interface even though the interface was only partially occupied by F-68. We hypothesized that F-68 stabilized rFVIII in these tests by strong association with the protein itself, rather than by its adsorption and subsequent establishment of a steric barrier at the air-water interface. To test this hypothesis, turbidimetric measurements of rFVIII aggregation behavior in solution and zeta potential measurements of rFVIII adsorption on (1 μm) colloidal silica particles, each in the presence of selected concentrations of F-68, were evaluated. Results recorded with these approaches were inconclusive, but not inconsistent with the original hypothesis

Physiological Interactions Of Calcium And Vitamin D In Colon

This study aimed to review the literature about possible physiological interactions of calcium and vitamin D in colon. Previous studies have indicated to protective effects of vitamin D and calcium in case of colon cancers. We wanted to check the physiological effects of both of vitamin D and calcium, and either of each of them alone. We suggested effects of metabolism through induction of changes in the levels of various biomarkers that have influences in carcinogenesis including p53, heat shock proteins, iNOS and WT1 gene

Palestinians and the Question of Refugee Resettlement

Scholars of international law and US politics discuss the question of refugee protection and resettlement in the wake of the war in Gaza. With the deaths of tens of thousands, the displacement of approximately two million, and the widespread destruction of homes and infrastructure in Gaza since October 7th, the international community faces a long-term humanitarian crisis. What does the future hold for Palestinian refugees and IDPs created by the current conflict? Many Palestinians justly insist on their right to return and rebuild their society. But how can the international community protect their lives and dignity in the meantime? Sensitive to the complexities involved, scholars of international law and US politics discuss the question of refugee protection and resettlement as a partial response to this urgent crisis, recognizing that all people have a right to safety and home. Panelists Include Prof. Wale Olumodimu (Gonzaga University) - will provide the international law context Dr. Shyam Sriram (Canisius University) - will provide the US social and political context Moderators Include Dr. Shannon Dunn (Gonzaga University) Dr. Brian Siebeking (Gonzaga University) with Dr. Ramadan Alkhatib of Gonzaga University providing additional comments. This opportunity is a feature of the Conversations on Israel and Gaza program, hosted by the Provost’s Office

Impact of chemotherapy for HIV-1 related lymphoma on residual viremia and cellular HIV-1 DNA in patients on suppressive antiretroviral therapy

The first cure of HIV-1 infection was achieved through complex, multimodal therapy including myeloablative chemotherapy, total body irradiation, anti-Thymocyte globulin, and allogeneic stem cell transplantation with a CCR5 delta32 homozygous donor. The contributions of each component of this therapy to HIV-1 eradication are unclear. To assess the impact of cytotoxic chemotherapy alone on HIV-1 persistence, we longitudinally evaluated low-level plasma viremia and HIV-1 DNA in PBMC from patients in the ACTG A5001/ALLRT cohort on suppressive antiretroviral therapy (ART) who underwent chemotherapy for HIV-1 related lymphoma without interrupting ART. Plasma HIV-1 RNA, total HIV-1 DNA and 2-LTR circles (2-LTRs) in PBMC were measured using sensitive qPCR assays. In the 9 patients who received moderately intensive chemotherapy for HIV-1 related lymphoma with uninterrupted ART, low-level plasma HIV-1 RNA did not change significantly with chemotherapy: median HIV-1 RNA was 1 copy/mL (interquartile range: 1.0 to 20) pre-chemotherapy versus 4 copies/mL (interquartile range: 1.0 to 7.0) post-chemotherapy. HIV-1 DNA levels also did not change significantly, with median prechemotherapy HIV-1 DNA of 355 copies/106 CD4+ cells versus 228 copies/106 CD4+ cells post-chemotherapy. 2-LTRs were detectable in 2 of 9 patients pre-chemotherapy and in 3 of 9 patients post-chemotherapy. In summary, moderately intensive chemotherapy for HIV-1 related lymphoma in the context of continuous ART did not have a prolonged impact on HIV-1 persistence. © 2014 Cillo et al

Psychometric properties of the Arabic version of the good death inventory (GDI-A) questionnaire tested on Palestinian family members of deceased adult cancer patients

Background Despite the importance of understanding the concept of good death (GD) from different cultural perspectives, it has not been assessed in Arab communities because of the unavailability of validated instruments. This study aimed to evaluate the psychometric properties of the Arabic version of the Good Death Inventory (GDI-A) questionnaire used among Palestinian bereaved family members of cancer patients. Methods A cross-sectional methodological study was applied. An online survey was adopted as a data collection method. The online survey was delivered through Qualtrics and posted in cancer and health-related social media groups on Facebook, the most commonly utilized social media platform in Palestine. A convenient and snowball sampling of 285 family members of deceased adult cancer patients was adopted. The participants were asked to complete GDI online survey. A confirmatory factor analysis (CFA), content validity, and internal consistency reliability were assessed. Results Participants showed a good perspective about death (M = 300.01, SD = 31.09). Significant differences in GDI-A total score were reported with the “patient’s relationship with family” (M = 303.02, SD = 31.42), F(2, 282) = 7.787, p = .001, “educational level” (M = 305.97, SD = 28.38), F(4, 280) = 3.685, p = .006, and “member’s relationship with the patient” (M = 311.74, SD = 16.57), F(5, 279) = 3.125, p = .009. The Arabic version scale-level content validity index and the scale-level content validity index-universal agreement were 0.96 and 0.85, respectively. Factor analysis with a varimax rotation matrix revealed that 16 factors explained 76.08% of the variance. Conclusion This study provides the literature with an Arabic questionnaire for understanding the concept of a GD from the perspective of bereaved families. The GDI Arabic translated version is a psychometrically robust instrument with satisfactory measurement, which can be used for evaluating a GD among bereaved families