61 research outputs found
The effects of different familial Alzheimer’s disease mutations on APP processing in vivo
Full text linkLife situation, coping and quality of life in people with high and low risk of developing Alzheimer's disease
No full textNo association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients
No full textConversion from preclinical to clinical stage of Alzheimer’s disease as shown by decline of cognitive function in carriers of the Swedish APP-mutation
Full text linkInvestigations of a CA repeat in the oestrogen receptor β gene in patients with Alzheimer's disease
No full textAllelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families
No full textApolipoprotein ∊4 Allele in Swedish Twins and Siblings with Alzheimer Disease
No full textSummary Allelic frequencies of apolipoprotein ∊4 were compared in 13 dizygotic twin pairs and 13 sibling pairs in which at least one member has Alzheimer disease (AD). Among discordant pairs of twins and siblings, frequencies were significantly greater in affected than intact partners. There was no significant difference in allelic frequencies between twins with a positive family history and twins with a negative family history. The ∊4 allele was more common in the sibling sample selected for family aggregation of AD than the twin sample. Several lines of evidence indicate that while the ∊4 allele appears to be one risk factor for AD, other etiological factors must be considered as well
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