Concentration effects of selected insecticides on brain acetylcholinesterase in the common carp (Cyprinus carpio L.)

The differential inhibition of acetylcholinesterase (AChE) by organophosphate (OP) and carbamate (C) is followed by the distinct duration of exposure effect on common carp AChE. Hence, in the present study in vivo exposure period effect and in vitro concentration-response of chlorfenvinphos, chlorpyrifos diazinon, and carbofuran were investigated on Cyprinus carpio L. AChE. Individuals of 1-year-old carp were exposed for 96 h to different concentrations of insecticides- after which AChE activity was measured in the brain. The highest concentrations of carbofuran (2.44 mg • L-1)- chlorfenvinphos (2.9 mgL-1), and diazinon (2.5 mg.L-1) killed at] the test animals after only 4 h, although there was no statistically significant difference from the control group's brain AChE activity. The lowest concentration significantly inhibited brain AChE after 96 h. Chlorfenvinphos was the most potent inhibitor in vivo and chlorpyrifos the least active inhibitor after 96 h of exposure time. In vitro experimentation with the same pesticide indicated that several concentrations inhibited 50% of the AChE activity (I50) ranging from 4.1 x 10-7 to 8.12X 10-4 M in both single inhibitory action and joint inhibitory effect. The results suggest that in biomonitoring programs carp brain AChE can be a good diagnostic tool for chronic OP nd C pollution

Water use efficiency and maximizing profitability of grain sorghum production in the Texas Panhandle

The reduction in the availability of irrigation water and the increase in pumping costs resulting from the decline in the Ogallala Aquifer make good management decisions more critical for the survival of the farm firm and the success of the agricultural sector in the Texas Panhandle. Response functions for irrigation and percentage potential evapotranspiration (PET) in the production of grain sorghum are estimated. The response functions are transferred into value product functions and combined with an irrigation energy cost function to determine the profit maximizing irrigation strategy. Three management decision variables; total water available, the level of irrigation and the water to meet crop ET requirements are evaluated. Grain sorghum yield, natural precipitation, irrigation, soil moisture content, potential evapotranspiration, and percent potential evapotranspiration (PET) data, collected over the period from 1998 through 2007 by commercial producers participating in the AgriPartners program are used to estimate the response functions. Results indicate that the optimum level of irrigation increases as the price of sorghum increases and decreases as the price of natural gas increases.Grain sorghum, ET, maximizing profit, irrigation efficiency, input use optimization, water conservation, Ogallala Aquifer, Texas Panhandle., Farm Management, Production Economics, Productivity Analysis, Resource /Energy Economics and Policy, Q12, Q15, Q25, Q32, and Q34,

Evaluating the impact of contour bunding technology on runoff, soil erosion and crop yield in southern Mali

United States Agency for International Developmen

SMART: Unique splitting-while-merging framework for gene clustering

Copyright @ 2014 Fa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Successful clustering algorithms are highly dependent on parameter settings. The clustering performance degrades significantly unless parameters are properly set, and yet, it is difficult to set these parameters a priori. To address this issue, in this paper, we propose a unique splitting-while-merging clustering framework, named “splitting merging awareness tactics” (SMART), which does not require any a priori knowledge of either the number of clusters or even the possible range of this number. Unlike existing self-splitting algorithms, which over-cluster the dataset to a large number of clusters and then merge some similar clusters, our framework has the ability to split and merge clusters automatically during the process and produces the the most reliable clustering results, by intrinsically integrating many clustering techniques and tasks. The SMART framework is implemented with two distinct clustering paradigms in two algorithms: competitive learning and finite mixture model. Nevertheless, within the proposed SMART framework, many other algorithms can be derived for different clustering paradigms. The minimum message length algorithm is integrated into the framework as the clustering selection criterion. The usefulness of the SMART framework and its algorithms is tested in demonstration datasets and simulated gene expression datasets. Moreover, two real microarray gene expression datasets are studied using this approach. Based on the performance of many metrics, all numerical results show that SMART is superior to compared existing self-splitting algorithms and traditional algorithms. Three main properties of the proposed SMART framework are summarized as: (1) needing no parameters dependent on the respective dataset or a priori knowledge about the datasets, (2) extendible to many different applications, (3) offering superior performance compared with counterpart algorithms.National Institute for Health Researc

Technical Efficiency of Sugarcane Monoculture and Sugarcane-Soybean Integration among Smallholder Farmers in Awendo Sub-County, Kenya

The demand for sugar in Kenya has been rising with low farm level productivity and high cost of production of USD 870 per MT. The ability of smallholder sugarcane farmers to improve sugarcane output levels and attain sustainable production depends on efficient farm practices, hence technical efficiency. The study analyzed technical efficiency of sugarcane-based cropping systems among smallholder farmers in Awendo Sub-County, Kenya. Primary cross-sectional data were collected from 246 randomly selected sugarcane farmers using multi-stage sampling method. The study identified two sugarcane-based cropping systems, namely; sugarcane monoculture which accounted for 62.6% of the cropping systems and sugarcane-soybean integration which accounted for 37.4 % of the cropping system, indicating that sugarcane monoculture dominated sugarcane based enterprise in the study area. The analysis employed Cobb Douglas stochastic production frontier model to estimate technical efficiency levels. A two-limit Tobit model was used to examine the factors influencing technical efficiency. Results indicated the highest output elasticity for land size (0.532) followed by herbicides (0.051). Fertilizer quantity and sugarcane cuttings had output elasticities of 0.029 and 0.015 respectively. The sum of the partial elasticities in the estimated model was 0.583. Results also showed that sugarcane-soybean integrators were more efficient than sugarcane monoculture farmers and land was found out to be the single most important variable in influencing the farmer’s efficiency. The mean technical efficiency of 62% and 64 % showed that the potential exist to increase output by 38% and 36% for non-integrators and integrators respectively with the present technology. This study recommends that sugarcane farmers be encouraged to allocate part of their land to production of soybean to enhance food security and improve household income. It further recommends that there is need for training sugarcane and soybean farmers on optimum utilization of farm inputs the study area. Keywords: Technical efficiency, Sugarcane monoculture, Sugarcane-Soybean Integration, Smallholder farme

Systèmes de production et pratiques à risque en agriculture urbaine: Cas du maraîchage dans la ville de Yamoussoukro en Côte d’Ivoire

La question de l’impact de l’agriculture urbaine sur l’environnement revient, fréquemment, au coeur des débats dans la gestion des villes africaines, comme Yamoussoukro. Les inquiétudes liées à la préservation de l’environnement urbain, eu égard à l’usage de pesticides et à la qualité des eaux utilisées, constituent une préoccupation prise en compte dans le cadre de cette étude. Celle-ci porte, aussi bien sur l’évaluation du risque sur l’environnement consécutif à de mauvaises pratiques agricoles que sur l’évaluation du risque sanitaire consécutif à l’usage des eaux usées. Pour atteindre cet objectif, la méthodologie utilisée a été d’une part, la collecte de données, à travers une enquête et d’autre part, des analyses au laboratoire. Il ressort que le maraîchage urbain à Yamoussoukro est une activité informelle. Les cultures pratiquées sont dominées par la laitue, l’oignon vert et la carotte. Le recours aux intrants, notamment les pesticides, est très répandu. Les dispositifs règlementaires sur la distribution des produits agrochimiques ne sont pas appliqués. Ainsi, 74% des pesticides recensés ne sont pas homologués pour les cultures maraîchères, 12% sont très toxiques (classe Ib) et 57% nocifs (classe II). Les risques encourus sont accentués par un traitement chimique qui n’est pas suffisamment maîtrisé. Les analyses physico-chimiques et microbiologiques ont mis en évidence, d’une part, des eaux d’irrigation aux caractéristiques très hétérogènes et d’autre part, une grande diversité microbienne et une contamination de ces eaux, suggérant des risques sanitaires avérés.Mots clés: cultures maraîchères, environnement, risque sanitaire, pesticides, eau

A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes

Novel drugs are required for the elimination of infections caused by filarial worms, as most commonly used drugs largely target the microfilariae or first stage larvae of these infections. Previous studies, conducted in vitro, have shown that inhibition of Hsp90 kills adult Brugia pahangi. As numerous small molecule inhibitors of Hsp90 have been developed for use in cancer chemotherapy, we tested the activity of several novel Hsp90 inhibitors in a fluorescence polarization assay and against microfilariae and adult worms of Brugia in vitro. The results from all three assays correlated reasonably well and one particular compound, NVP-AUY922, was shown to be particularly active, inhibiting Mf output from female worms at concentrations as low as 5.0 nanomolar after 6 days exposure to drug. NVP-AUY922 was also active on adult worms after a short 24 h exposure to drug. Based on these in vitro data, NVP-AUY922 was tested in vivo in a mouse model and was shown to significantly reduce the recovery of both adult worms and microfilariae. These studies provide proof of principle that the repurposing of currently available Hsp90 inhibitors may have potential for the development of novel agents with macrofilaricidal properties

Case study of Daga-Birame CSV for CCAFS ISP11/6.1.2 – Senegal

Senegal, with 196,712 km2 land area, is located at the extreme west of the African continent (Longitudes 11°21W - 17°32N and Latitudes 12°8N - 16°41N). The country’s soils are in general of low fertility, fragile and very susceptible to wind and water erosion. The climate is of Sudano-Sahelian type characterized by alternating dry season (November to May) and rainy season (June to October). The 700 km coastline brings climatic differences between coastal areas and inland zones. Rainfall amount follows a latitudinal variation going from 300 mm in the north semi-desertic areas to 1200 mm in the south. Senegal is divided into 7 agro-ecological zones for management perspectives: River Valley, Niayes, Groundnut Basin (North and South), Silvo-Pastoral zone, Eastern Senegal and Upper Casamance, Lower Casamance (CIAT-BFS/USAID, 2016). The country’s economy is mainly driven by crop and livestock production contributing 17% of the GDP and employing about 70% of the population (NAPA, Republic of Senegal 2006). Like other sub-Saharan African countries, Senegal faces food insecurity as a consequence of climate variability and change combined with other global changes (Zougmoré et al., 2015)

Effects of feed and health interventions on small ruminant production in mixed crop-livestock systems in Southern Mali

In Mali, small ruminants are a necessary part of mixed crop and livestock systems, and they fulfill various roles in the food security of households as sources of meat and milk, and means of additional income to meet food and cash needs. However, small ruminant production is challenged by the poor performance of animals, which is mainly caused by inadequate nutrition and diseases. A pilot study that combined feed and health interventions was conducted in two villages, Sirakele and Zanzoni in Koutiala District in the south of the country. The objective was to assess the effects of the combined interventions on small ruminant production in mixed crop-livestock systems. Zanzoni served as control, and Sirakele received both feed and health interventions. Twenty households were randomly selected in each village and the study lasted one year, from August 2016 to August 2017. Results showed that within a year the average goat and sheep flock size in the feed and health intervention group doubled, whereas it mostly remained the same in the control group. The mortality rate was significantly lower in the treatment group than in the control one. In addition, the goats and sheep gained 42.98 ± 3.28 and 47.12 ± 2.73 g/day in the treatment group, whereas they only gained 22.59 ± 2.29 and 16.58 ± 2.74 g/day in the control group, respectively. The results confirmed that feed and health interventions significantly improved small ruminant production

Possible alternative for national supply of seed potatoes (Solanum tuberosum L.) from in vitro culture at the Agro-physio-genetic and Plants Biotechnology laboratory of IPR / IFRA of Katibougou, Mali

The enhancement of the potential for reducing food insecurity and poverty through potato cultivation in Mali is largely limited by difficult access to quality seed. In trying to find ways to reduce these shortcomings outlined above that work has been done. The objective of this work was to assess the economic profitability of the local potato seed sourcing scheme from in vitro propagation and to analyze the competitiveness of the sourcing scheme from imported elite seed. The technical and economic feasibility of the local potato seed supply scheme was assessed at five levels. The first concerns the production of vitro-plants in the laboratory, the second the production of mini zero generation tubers (G0). Regarding the other three levels of evaluation, they were carried out in collaboration with the seed cooperatives by successive multiplication from mini-tubers to obtain seeds of one “G1”, two “G2” and three “G3” generations". The profitability of the procurement scheme from the elite imported and multiplied once seed was evaluated in order to analyze its competitiveness in relation to the local circuit. The valuation indicates positive profit margins. However, it should be noted that the economic efficiency coefficients of vitro-propagation (0.77) and tunnel multiplication (0.75) are less than 1. The production cost of one kilogram of G3 is equal to at 463.39 F CFA. A profit margin of 456.61 F CFA / kg emerges between this unit production cost and the selling price of imported seeds, which amounts on average to 920 F CFA / kg. The production of plants is technically feasible and profitable with a cost price of one kg of G3 in the order of 500 to 600 F CFA against 900 to 1000 F CFA / kg for imported seed. La valorisation du potentiel de réduction de l’insécurité alimentaire et de la pauvreté à travers la culture de la pomme de terre au Mali est limitée en grande partie par l’accès difficile à la semence de qualité. En essayant de trouver des moyens pour réduire ces insuffisances soulignées ci-dessus que ce travail a été effectué. Le présent travail avait pour objectif d’évaluer la rentabilité économique du schéma d’approvisionnement locale en semences de pomme de terre à partir de la vitro propagation et d’analyser la compétitivité du schéma d’approvisionnement à partir de la semence élite importées. La faisabilité technico-économique du schéma d’approvisionnement local en semences de pomme de terre était évaluée à cinq niveaux. Le premier concerne la production de vitro-plants au laboratoire, le deuxième la production de mini tubercules de génération zéro (G0). Pour ce qui concerne les trois autres niveaux d’évaluation, ils ont été réalisés en collaboration avec les coopératives semencières par multiplications successives à partir de mini-tubercules pour obtenir des semences de génération une «G1», deux «G2» et trois «G3». La rentabilité, du schéma d’approvisionnement à partir de la semence élite importée et multipliée une fois, a été évaluée en vue d’analyser sa compétitivité en rapport avec le circuit local. L’évaluation indique des marges bénéficiaires positives. Cependant, il faut remarquer que les coefficients d’efficacité économiques de la vitro-propagation (0,77) et de la multiplication sous tunnels (0,75) sont inférieurs à 1. Le coût de production d’un kilogramme de G3 est égal à 463,39 F CFA. Une marge bénéficiaire de 456,61 F CFA / kg se dégage entre ce coût de production unitaire et le prix de vente des semences importées qui s’élève en moyenne à 920 F CFA / kg. La production de plants est techniquement faisable et rentable avec un coût de revient d’un kg de G3 de l’ordre de 500 à 600 F CFA contre 900 à 1 000 F CFA / kg pour la semence importée