Stainless steel 301 and Inconel 718 hydrogen embrittlement

Conditions and results of tensile tests of 26 Inconel 718 and four cryoformed stainless steel specimens are presented. Conclusions determine maximum safe hydrogen operating pressure for cryogenic pressure vessels and provide definitive information concerning flaw growth characteristics under the most severe temperature and pressure condition

Polarization of X-ray lines from galaxy clusters and elliptical galaxies - a way to measure tangential component of gas velocity

We study the impact of gas motions on the polarization of bright X-ray emission lines from the hot intercluster medium (ICM). The polarization naturally arises from resonant scattering of emission lines owing to a quadrupole component in the radiation field produced by a centrally peaked gas density distribution. If differential gas motions are present then a photon emitted in one region of the cluster will be scattered in another region only if their relative velocities are small enough and the Doppler shift of the photon energy does not exceed the line width. This affects both the degree and the direction of polarization. The changes in the polarization signal are in particular sensitive to the gas motions perpendicular to the line of sight. We calculate the expected degree of polarization for several patterns of gas motions, including a slow inflow expected in a simple cooling flow model and a fast outflow in an expanding spherical shock wave. In both cases, the effect of non-zero gas velocities is found to be minor. We also calculate the polarization signal for a set of clusters, taken from large-scale structure simulations and evaluate the impact of the gas bulk motions on the polarization signal. We argue that the expected degree of polarization is within reach of the next generation of space X-ray polarimeters.Comment: 25 pages, 18 figures, accepted to MNRA

What do the recent American Heart Association/American College of Cardiology Foundation Clinical Practice Guidelines tell us about the evolving management of coronary heart disease in older adults?

Biological aging predisposes older adults to increased cardiovascular disease (CHD) and greater disease complexity. Given the high age-related prevalence of CHD and age-related compounding factors, the recently updated American Heart Association/American College of Cardiology Foundation CHD-related guidelines increased their focus on older patients. These guidelines are predominately evidence-based (using data from quality randomized clinical trials) and are organized to delineate medications and procedures that best treat particular cardiovascular diseases. While such rationale and thought work well in young and middle aged adults, they become problematic in patients who are very old. Data pertaining to adults aged ≥ 80 are virtually absent from most randomized clinical trials, and even in the instances when very old patients were included, eligibility criteria typically excluded candidates with co-morbidities and complexities of customary CHD patients. While medications and interventions yielding benefit in clinical trials should theoretically produce the greatest benefits for patients with high intrinsic risk, age-related cardiovascular complexities also increase iatrogenic risks. Navigating between the potential for high benefit and high risk in “evidence-based” cardiovascular management remains a key Geriatric Cardiology challenge. In this review we consider the expanded Geriatric Cardiology content of current guidelines, acknowledging both the progress that has been made, as well as the work that still needs to be accomplished to truly address the patient-centered priorities of older CHD patients

CHANDRA observations of the NGC 1550 galaxy group -- implication for the temperature and entropy profiles of 1 keV galaxy groups

We present a detailed \chandra study of the galaxy group NGC 1550. For its temperature (1.37$\pm$0.01 keV) and velocity dispersion ($\sim$ 300 km s$^{-1}$), the NGC 1550 group is one of the most luminous known galaxy groups (L$_{\rm bol}$ = 1.65$\times10^{43}$ erg s$^{-1}$ within 200 kpc, or 0.2 \rv). We find that within $\sim 60$ kpc, where the gas cooling time is less than a Hubble time, the gas temperature decreases continuously toward the center, implying the existence of a cooling core. The temperature also declines beyond $\sim$ 100 kpc (or 0.1 \rv). There is a remarkable similarity of the temperature profile of NGC 1550 with those of two other 1 keV groups with accurate temperature determination. The temperature begins to decline at 0.07 - 0.1 \rv, while in hot clusters the decline begins at or beyond 0.2 \rv. Thus, there are at least some 1 keV groups that have significantly different temperature profiles from those of hot clusters, which may reflect the role of non-gravitational processes in ICM/IGM evolution. NGC 1550 has no isentropic core in its entropy profile, in contrast to the predictions of `entropy-floor' simulations. We compare the scaled entropy profiles of three 1 keV groups (including NGC 1550) and three 2 - 3 keV groups. The scaled entropy profiles of 1 keV groups show much larger scatter than those of hotter systems, which implies varied pre-heating levels. We also discuss the mass content of the NGC 1550 group and the abundance profile of heavy elements.Comment: emulateapj5.sty, 18 pages, 11 figures (including 4 color), to appear in ApJ, v598, n1, 20 Nov 200

Funding Translational Medicine via Public Markets: The Business Development Company

A business development company (BDC) is a type of closed-end investment fund with certain relaxed requirements that allow it to raise money in the public equity and debt markets, and can be used to fund multiple early-stage biomedical ventures, using financial diversification to de-risk translational medicine. By electing to be a “Regulated Investment Company” for tax purposes, a BDC can avoid double taxation on income and net capital gains distributed to its shareholders. BDCs are ideally suited for long-term investors in biomedical innovation, including: (i) investors with biomedical expertise who understand the risks of the FDA approval process, (ii) “banking entities,” now prohibited from investing in hedge funds and private equity funds by the Volcker Rule, but who are permitted to invest in BDCs, subject to certain restrictions, and (iii) retail investors, who traditionally have had to invest in large pharmaceutical companies to gain exposure to similar assets. We describe the history of BDCs, summarize the requirements for creating and managing them, and conclude with a discussion of the advantages and disadvantages of the BDC structure for funding biomedical innovatio

Chandra Observations of Gas Stripping in the Elliptical Galaxy NGC 4552 in the Virgo Cluster

We use a 54.4 ks Chandra observation to study ram-pressure stripping in NGC4552 (M89), an elliptical galaxy in the Virgo Cluster. Chandra images in the 0.5-2 keV band show a sharp leading edge in the surface brightness 3.1 kpc north of the galaxy center, a cool (kT =0.51^{+0.09}_{-0.06} keV) tail with mean density n_e ~5.4 +/- 1.7 x 10^{-3} cm^{-3} extending ~10 kpc to the south of the galaxy, and two 3-4 kpc horns of emission extending southward away from the leading edge. These are all features characteristic of supersonic ram-pressure stripping of galaxy gas, due to NGC4552's motion through the surrounding Virgo ICM. Fitting the surface brightness profile and spectra across the leading edge, we find the galaxy gas inside the edge is cooler (kT = 0.43^{+0.03}_{-0.02} keV) and denser (n_e ~ 0.010 cm^{-3}) than the surrounding Virgo ICM (kT = 2.2^{+0.7}_{-0.4} keV and n_e = 3.0 +/- 0.3 x 10^{-4} cm^{-3}). The resulting pressure ratio between the free-streaming ICM and cluster gas at the stagnation point is ~7.6^{+3.4}_{-2.0} for galaxy gas metallicities of 0.5^{+0.5}_{-0.3} Zsolar, which suggests that NGC4552 is moving supersonically through the cluster with a velocity v ~ 1680^{+390}_{-220} km/s (Mach 2.2^{+0.5}_{-0.3}) at an angle xi ~ 35 +/- 7 degrees towards us with respect to the plane of the sky.Comment: 31 pages, 12 figures, ApJ, in press; paper split into 2 parts, Paper I(sec 1-3) here, added figs and discussion to conform to published version; Paper II (sec. 4) in astro-ph/060440

High-Energy sources before INTEGRAL -- INTEGRAL reference catalog --

We describe the INTEGRAL reference catalog which classifies previously known bright X-ray and gamma-ray sources before the launch of INTEGRAL. These sources are, or have been at least once, brighter than ~1 mCrab above 3 keV, and are expected to be detected by INTEGRAL. This catalog is being used in the INTEGRAL Quick Look Analysis to discover new sources or significantly variable sources. We compiled several published X-ray and gamma-ray catalogs, and surveyed recent publications for new sources. Consequently, there are 1122 sources in our INTEGRAL reference catalog. In addition to the source positions, we show an approximate spectral model and expected flux for each source, based on which we derive expected INTEGRAL counting rates. Assuming the default instrument performances and at least ~10^5 sec exposure time for any part of the sky, we expect that INTEGRAL will detect at least ~700 sources below 10 keV and ~400 sources above 20 keV over the mission life.Comment: Accepted to A&A Letter INTEGRAL special issu

The ALMA Discovery of the Rotating Disk and Fast Outflow of Cold Molecular Gas in NGC 1275

We present ALMA Band 6 observations of the CO(2-1), HCN(3-2), and HCO$^{+}$(3-2) lines in the nearby radio galaxy / brightest cluster galaxy (BCG) of NGC 1275 with the spatial resolution of $\sim20$ pc. In the previous observations, CO(2-1) emission was detected as radial filaments lying in the east-west direction. We resolved the inner filament and found that the filament cannot be represented by a simple infalling stream both morphologically and kinematically. The observed complex nature of the filament resembles the cold gas structure predicted by recent numerical simulations of cold chaotic accretion. A crude estimate suggests that the accretion rate of the cold gas can be higher than that of hot gas. Within the central 100 pc, we detected a rotational disk of the molecular gas whose mass is \sim10^{8} M_{\sun}. This is the first evidence of the presence of massive cold gas disk on this spatial scale for BCGs. The disk rotation axis is approximately consistent with the axis of the radio jet on subpc scales. This probably suggests that the cold gas disk is physically connected to the innermost accretion disk which is responsible for jet launching. We also detected absorption features in the HCN(3-2) and HCO$^{+}$(3-2) spectra against the radio continuum emission mostly radiated by $\sim1.2$-pc size jet. The absorption features are blue-shifted from the systemic velocity by $\sim$300-600~km~s$^{-1}$, which suggests the presence of outflowing gas from the active galactic nucleus (AGN). We discuss the relation of the AGN feeding with cold accretion, the origin of blue-shifted absorption, and estimate of black hole mass using the molecular gas dynamics.Comment: Version 2 (accepted version). 18 pages, 16 figures. Accepted for publication in Ap