Willingness To Donate Blood During the Summer

Introduction. Each year donation rates fall in the summer months straining blood banks’ capacities to meet local demands. In hopes of identifying factors to increase summer donations, our study investigated donor reported barriers which influence summer donations habits.Methods. An anonymous 16 question survey investigating various donation factors was administered across multiple American Red Cross (ARC) donation centers in Vermont. Questions addressed donor demographics, frequency of blood donation, preference in appointment making modalities including smartphone app use, summer travel habits, willingness to donate during vacation, and factors that deter donors from donating on vacation.Results. A total of 292 surveys were received. Survey respondents across multiple demographic groups cited similar barriers to summer donation, namely “Too busy” (27.5 %) and “Traveling is a time for me to relax.” (30.6 %). Of the respondents who travel in the summer, very few reported donating while traveling (3.4 %). Summer donation rates between summertime travelers (36.5 %) and non-travelers (36.4 %) were essentially equivalent. The most preferred methods of scheduling appointments were via ARC website (45.6 %) and phone (28.4%). Willingness to use the ARC app was highest among respondents ages of 18 to 34 (45-55%) and lowest among ages 55 and older (13-15%). Of respondents with no prior knowledge of summer seasonal shortages (22 %), 2/3rds indicated newfound motivation to donate.Conclusion. Regardless of travel, increasing awareness of summer shortages may increase summer donations. Use of donor websites and smartphone apps may be instrumented as part of recruitment efforts.https://scholarworks.uvm.edu/comphp_gallery/1239/thumbnail.jp

Hydroxyurea-induced hyperpigmentation with iron deposition

Hydroxyurea is a chemotherapeutic agent that is used in the treatment of various hematological diseases including chronic myelogenous leukemia, polycythemia vera, and sickle cell anemia. Hydroxyurea is also used to treat psoriasis. Drug-induced hyperpigmentation is a known cutaneous side effect of hydroxyurea along with xerosis, dermal ulcers, and dermatomyositis-like eruptions. Hyperpigmentation has been observed in the oral mucosa, nails, and in a generalized or a diffuse pattern. The mechanism of hyperpigmentation related to hydroxyurea is believed to be correlated with increased melanin. Classically, clinical types of diffuse hyperpigmentation owing to iron deposition in the dermis have been associated with minocycline and not with hydroxyurea. We report a novel case in which hydroxyurea hyperpigmentation is associated with iron deposition

Investigations on Anti-Diabetic Medicinal Plants Used by Tribal Inhabitants of Nalamankadai, Chitteri Reserve Forest, Dharmapuri, India

An ethnobotanical survey was conducted to collect information about medicinal plants used for the treatment of diabetics and associated complications by tribals in Nalamankadai village of Chitteri Hills, Dharmapuri District. The indigenous knowledge of local traditional healers and native plants used for the treatment of diabetics related health disorders were collected through questionnaire and personal interviews. A total of 10 informants with in the age group of 50 to 68 were interviewed, among them two were tribal practitioners. The investigation revealed that, the traditional healers and the inhabitants use 29 species of plants distributed in 28 genera belonging to 22 families to treat diabetics and related complications. Results depict that fresh plant materials were invariably preferred for the treatment of long term complications associated with diabetics. Anti-diabetic medicinal plants used by Malayali’s in Chitteri have been listed along with plant parts used

Star formation in bulgeless late type galaxies: clues to their evolution

We present GMRT 1280 MHz radio continuum observations and follow-up optical studies of the disk and nuclear star formation in a sample of low luminosity bulgeless galaxies. The main aim is to understand bulge formation and overall disk evolution in these late type galaxies. We detected radio continuum from five of the twelve galaxies in our sample; the emission is mainly associated with disk star formation. Only two of the detected galaxies had extended radio emission; the others had patchy disk emission. In the former two galaxies, NGC3445 and NGC4027, the radio continuum is associated with star formation triggered by tidal interactions with nearby companion galaxies. We did follow-up Halpha imaging and nuclear spectroscopy of both galaxies using the Himalayan Chandra Telescope (HCT). The Halpha emission is mainly associated with the strong spiral arms. The nuclear spectra indicate ongoing nuclear star formation in NGC3445 and NGC4027 which maybe associated with nuclear star clusters. No obvious signs of AGN activity were detected. Although nearly bulgeless, both galaxies appear to have central oval distortions in the R band images; these could represent pseudobulges that may later evolve into large bulges. We thus conclude that tidal interactions are an important means of bulge formation and disk evolution in bulgeless galaxies; without such triggers these galaxies appear to be low in star formation and overall disk evolution.Comment: 12 pages, 14 figures, to appear in MNRA

Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure

Until recently, it has only been possible to grow crystals of peanut lectin when complexed with sugar ligands. It is now shown that it is possible to grow peanut lectin crystals at acidic pH in the presence of oligopeptides corresponding to a loop in the lectin molecule. Crystals have also been prepared in the presence of these peptides as well as lactose. Low-pH crystal forms of the lectin-lactose complex similar to those obtained at neutral pH have also been grown. Thus, crystals of peanut lectin grown under different environmental conditions, at two pH values with and without sugar bound to the lectin, are now available. They have been used to explore the plasticity and hydration of the molecule. A detailed comparison between different structures shows that the lectin molecule is sturdy and that the effect of changes in pH, ligand binding and environment on it is small. The region involving the curved front β-sheet and the loops around the second hydrophobic core is comparatively rigid. The back β-sheet involved in quaternary association, which exhibits considerable variability, is substantially flexible, as is the sugar-binding region. The numbers of invariant water molecules in the hydration shell are small and they are mainly involved in metal coordination or in stabilizing unusual structural features. Small consistent movements occur in the combining site upon sugar binding, although the site is essentially preformed