3,955 research outputs found
Synthesis of (S)- and (R)-5-oxo-piperazine-2-carboxylic acid and its application to peptidomimetics.
Transverse effects in multifrequency Raman generation
The theory of ultrabroadband multifrequency Raman generation is extended, for the first time, to allow for beam-propagation effects in one and two transverse dimensions. We show that a complex transverse structure develops even when diffraction is neglected. In the general case, we examine how the ultrabroadband multifrequency Raman generation process is affected by the intensity, phase quality, and width of the input beams, and by the length of the Raman medium. The evolution of power spectra, intensity profiles, and global characteristics of the multifrequency beams are investigated and explained. In the two-dimensional transverse case, bandwidths comparable to the optical carrier frequency, spanning the whole visible spectrum and beyond, are still achievable
Real-time Loss Estimation for Instrumented Buildings
Motivation. A growing number of buildings have been instrumented to measure and record
earthquake motions and to transmit these records to seismic-network data centers to be archived and
disseminated for research purposes. At the same time, sensors are growing smaller, less expensive to
install, and capable of sensing and transmitting other environmental parameters in addition to
acceleration. Finally, recently developed performance-based earthquake engineering methodologies
employ structural-response information to estimate probabilistic repair costs, repair durations, and
other metrics of seismic performance. The opportunity presents itself therefore to combine these
developments into the capability to estimate automatically in near-real-time the probabilistic seismic
performance of an instrumented building, shortly after the cessation of strong motion. We refer to
this opportunity as (near-) real-time loss estimation (RTLE).
Methodology. This report presents a methodology for RTLE for instrumented buildings. Seismic
performance is to be measured in terms of probabilistic repair cost, precise location of likely physical
damage, operability, and life-safety. The methodology uses the instrument recordings and a Bayesian
state-estimation algorithm called a particle filter to estimate the probabilistic structural response of
the system, in terms of member forces and deformations. The structural response estimate is then
used as input to component fragility functions to estimate the probabilistic damage state of structural
and nonstructural components. The probabilistic damage state can be used to direct structural
engineers to likely locations of physical damage, even if they are concealed behind architectural
finishes. The damage state is used with construction cost-estimation principles to estimate
probabilistic repair cost. It is also used as input to a quantified, fuzzy-set version of the FEMA-356
performance-level descriptions to estimate probabilistic safety and operability levels.
CUREE demonstration building. The procedure for estimating damage locations, repair costs, and
post-earthquake safety and operability is illustrated in parallel demonstrations by CUREE and
Kajima research teams. The CUREE demonstration is performed using a real 1960s-era, 7-story, nonductile
reinforced-concrete moment-frame building located in Van Nuys, California. The building is
instrumented with 16 channels at five levels: ground level, floors 2, 3, 6, and the roof. We used the
records obtained after the 1994 Northridge earthquake to hindcast performance in that earthquake.
The building is analyzed in its condition prior to the 1994 Northridge Earthquake. It is found that,
while hindcasting of the overall system performance level was excellent, prediction of detailed damage
locations was poor, implying that either actual conditions differed substantially from those shown on
the structural drawings, or inappropriate fragility functions were employed, or both. We also found
that Bayesian updating of the structural model using observed structural response above the base of
the building adds little information to the performance prediction. The reason is probably that
Real-Time Loss Estimation for Instrumented Buildings
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structural uncertainties have only secondary effect on performance uncertainty, compared with the
uncertainty in assembly damageability as quantified by their fragility functions. The implication is
that real-time loss estimation is not sensitive to structural uncertainties (saving costly multiple
simulations of structural response), and that real-time loss estimation does not benefit significantly
from installing measuring instruments other than those at the base of the building.
Kajima demonstration building. The Kajima demonstration is performed using a real 1960s-era
office building in Kobe, Japan. The building, a 7-story reinforced-concrete shearwall building, was not
instrumented in the 1995 Kobe earthquake, so instrument recordings are simulated. The building is
analyzed in its condition prior to the earthquake. It is found that, while hindcasting of the overall
repair cost was excellent, prediction of detailed damage locations was poor, again implying either that
as-built conditions differ substantially from those shown on structural drawings, or that
inappropriate fragility functions were used, or both. We find that the parameters of the detailed
particle filter needed significant tuning, which would be impractical in actual application. Work is
needed to prescribe values of these parameters in general.
Opportunities for implementation and further research. Because much of the cost of applying
this RTLE algorithm results from the cost of instrumentation and the effort of setting up a structural
model, the readiest application would be to instrumented buildings whose structural models are
already available, and to apply the methodology to important facilities. It would be useful to study
under what conditions RTLE would be economically justified. Two other interesting possibilities for
further study are (1) to update performance using readily observable damage; and (2) to quantify the
value of information for expensive inspections, e.g., if one inspects a connection with a modeled 50%
failure probability and finds that the connect is undamaged, is it necessary to examine one with 10%
failure probability
High-technology elements for thin-film photovoltaic applications :a demand-supply outlook on the basis of current energy and PV market growths scenarios
On the basis of current energy and photovoltaic market outlooks and scenarios, the total growth rate potential of thin-film photovoltaic (PV) techniques have been analysed and calculated. For the European Photovoltaic Industry Association (EPIA) Advanced Scenario [1] total thin-film PV annual production values of 2.4 GWp for 2010, 25 GWp for 2020 and 132 GWp for 2030, were calculated. These values were used to estimate individual annual production for each thin-film technology in order to predict the future thin-film PV material needs for indium, selenium, tellurium, germanium and gallium. Considering global reserve and refinery data, this work also provides estimations on the current static depletion time of these elements. Such estimations are of course an approximation but emphasise that some of the considered elements are highly constrained when assuming steady production rates. This is particularly the case for indium, for which we calculated a static depletion time of 22 years. Selenium and tellurium could be also in danger of running out soon if their consumption increases. This implies that additional efforts are needed in the exploration and evaluation of mineral deposits which can supply these scarce elements such as the deposits of the Iberian Pyrite Belt
Quantifying uncertainties in precipitation: a case study from Greece
The main objective of the present study was the examination and the quantification of the uncertainties in the precipitation time series over the Greek area, for a 42-year time period. The uncertainty index applied to the rainfall data is a combination (total) of the departures of the rainfall season length, of the median data of the accumulated percentages and of the total amounts of rainfall. Results of the study indicated that all the stations are characterized, on an average basis, by medium to high uncertainty. The stations that presented an increasing rainfall uncertainty were the ones located mainly to the continental parts of the study region. From the temporal analysis of the uncertainty index, it was demonstrated that the greatest percentage of the years, for all the stations time-series, was characterized by low to high uncertainty (intermediate categories of the index). Most of the results of the uncertainty index for the Greek region are similar to the corresponding results of various stations all over the European region
Generation of angular-momentum-dominated electron beams from a photoinjector
Various projects under study require an angular-momentum-dominated electron
beam generated by a photoinjector. Some of the proposals directly use the
angular-momentum-dominated beams (e.g. electron cooling of heavy ions), while
others require the beam to be transformed into a flat beam (e.g. possible
electron injectors for light sources and linear colliders). In this paper, we
report our experimental study of an angular-momentum-dominated beam produced in
a photoinjector, addressing the dependencies of angular momentum on initial
conditions. We also briefly discuss the removal of angular momentum. The
results of the experiment, carried out at the Fermilab/NICADD Photoinjector
Laboratory, are found to be in good agreement with theoretical and numerical
models.Comment: 8 pages, 7 figures, submitted to Phys. Rev. ST Accel. Beam
Relevanz suszeptibilitätsinduzierter geometrischer Fehlkodierungen für die Validität MR-basierter Knorpelvolumen- und -dickenmessungen im Kniegelenk - Relevance of susceptibility-induced geometrical distortion for the accuracy of MR-based cartilage volume and thickness measurement
The aim of the present study was to analyze the relevance of susceptibility-induced geometrical distortion to the accuracy of MR-based cartilage volume and thickness measurement in the human knee joint. Nine cadaveric knee joints were imaged in the sagittal plane with MRI at a resolution of a x 0.31 x 0.81 mm³, using a fat-suppressed gradient echo sequence, with a normal gradient orientation and also with the frequency- and phase-encoding directions changed. CT arthrographic data sets were then obtained. On the basis of 3-D constructions, we determined the cartilage volume and, with a 3-D minimal distance algorithm, the thickness distribution, of the patella, femur and tibia. Irrespective of the gradient orientation, good agreement was observed between MRI and CT arthrography in terms of cartilage volumes and maximum cartilage thickness. With a normal gradient orientation the volume was overestimated by 2.5 % in MRI, and 2.3 % when the gradients were changed. The maximum cartilage thickness was underestimated by 0.24 intervals (interval = 0.5 mm) with a normal gradient orientation, and by 0.22 intervals when the gradient orientation was changed. In none of the joint surfaces was a relevant difference between the two methods observed. It can be shown that, using high-resolution, fat-suppressed gradient-echo sequences - suseeptibility-induced geometrical distortion has no significant effect on the accuracy of KR-based cartilage volume and thickness measurements. MRI would therefore appear suitable for the design of patient-specific finite element models with the aim of analysing load transmission in diarthrodial joints and planning surgical interventions
Präzision MRT-basierter Gelenkflächen- und Knorpeldickenanalysen im Kniegelenk bei Verwendung einer schnellen Wasseranregungs-Sequenz und eines semiautomatischen Segmentierungs-Algorithmus
The aim of this study was to analyse the precision of three-dimensional joint surface and cartilage thickness measurements in the knee, using a fast, high-resolution water-excitation sequence and a semiautomated segmentation algorithm. The knee joint of 8 healthy volunteers, aged 22 to 29 years, were examined at a resolution of 1.5 mm x 0.31 mm x 0.31 mm, with four sagittal data sets being acquired after repositioning the joint. After semiautomated segmentation with a B-spline Snake algorithm and 3D reconstruction of the patellar, femoral and tibial cartilages, the joint surface areas (triangulation), cartilage volume, and mean and maximum thickness (Euclidean distance transformation) were analysed, independently of the orientation of the sections. The precision (CV%) for the surface areas was 2.1 to 6.6%. The mean cartilage thickness and cartilage volume showed coefficients of 1.9 to 3.5% (except for the femoral condyles), the value for the medial femoral condyle being 9.1%, and for the lateral condyle 6.5%. For maximum thickness, coefficients of between 2.6 and 5.9% were found. In the present study we investigate for the first time the precision of MRI-based joint surface area measurements in the knee, and of cartilage thickness analyses in the femur. Using a selective water-excitation sequence, the acquisition time can be reduced by more than 50%. The poorer precision in the femoral condyles can be attributed to partial Volume effects that occur at the edges of the joint surfaces with a sagittal image protocol. Since MRI is non-invasive, it is highly suitable for examination of healthy subjects (generation of individual finite element models, analysis of functional adaptation to mechanical stimulation, measurement of cartilage deformation in vivo) and as a diagnostic tool for follow-up, indication for therapy, and objective evaluation of new therapeutic agents in osteoarthritis
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