Doping In Sports: Do Parents Matter?

Athletes exist and function in an environment of complex relationships; however, little is known about the influence of particular relationships for athletes’ attitudes, beliefs and behaviors towards doping in sport. Among adolescent and young adult athlete populations, parents and coaches have been highlighted as particularly influential, but when and how they influence athletes in this context is unknown. Therefore, this study aimed to explore the role of significant others in this domain. Design: Cross-sectional qualitative methodology. Method: Semi-structured interviews were conducted with 14 British (M = 8) track and field student-athletes. Thematic analysis was employed to analyze the transcripts. Results: Prominently, the parent-athlete relationship influenced athletes’ lives in and beyond sport. Parents shape(d) athletes’ personal morals by establishing their initial sense of right and wrong. In turn, this appears to guide athletes’ decision-making and behaviors even after leaving the family home. Additionally, parents impacted the trajectory of participants’ athletic careers and their approach toward sport in general. Ensuing from this, participants exhibit a desire to give back to their parents. Cumulatively, the parent-athlete relationship (in)directly deters athletes from doping. Conclusion: Given the enduring significance of the parent-athlete relationship for shaping athletes’ attitudes, experiences and behaviors towards doping, parents should be prioritized with targeted anti-doping education. Specifically, parents should be provided with doping knowledge (e.g., risks, warning signs, consequences), and then equipped and empowered to transmit this information to athletes. Such an approach has the potential to simultaneously increase the engagement of parents and athletes in anti-doping efforts and education

Transkingdom Networks: A Systems Biology Approach to Identify Causal Members of Host-Microbiota Interactions

Improvements in sequencing technologies and reduced experimental costs have resulted in a vast number of studies generating high-throughput data. Although the number of methods to analyze these "omics" data has also increased, computational complexity and lack of documentation hinder researchers from analyzing their high-throughput data to its true potential. In this chapter we detail our data-driven, transkingdom network (TransNet) analysis protocol to integrate and interrogate multi-omics data. This systems biology approach has allowed us to successfully identify important causal relationships between different taxonomic kingdoms (e.g. mammals and microbes) using diverse types of data

Client abuse to public welfare workers: theoretical framework and critical incident case study

We analyse a case study of workers’ experience of client abuse in a Danish public welfare organisation. We make an original contribution by putting forward two different theoretical expectations of the case. One expectation is that the case follows a pattern of customer abuse processes in a social market economy – in which worker are accorded power and resources, in which workers tend to frame the abuse as the outcome of a co-citizen caught in system failure, and in which workers demonstrate some resilience to abuse. Another expectation is that New Public Management reforms push the case to follow patterns of customer abuse associated with a liberal market economy – in which the customer is treated as sovereign against the relatively powerless worker, and in which workers bear heavy emotional costs of abuse. Our findings show a greater match to the social processes of abuse within a social market economy

“I don’t know if I would report them”: Student-athletes’ thoughts, feelings and anticipated behaviours on blowing the whistle on doping in sport.

Revisions to global anti-doping policy and growing evidence of systematic doping in sport means athletes and athlete support personnel are increasingly encouraged to ‘blow the whistle’ on doping. Yet, individuals’ thoughts, feelings, and anticipated behaviours in reporting wrongdoing of this kind are unknown, hindering its promotion. To inform current anti-doping efforts, this study explored student-athletes’ anticipated behaviours relative to blowing the whistle on performance enhancing drug (PED) use and their underpinning attitudes. Design: Qualitative methodology. Method: Semi-structured interviews were conducted with 28 track and field university student-athletes from the UK (N = 14) and US (N = 14). Transcripts were analysed using thematic analysis. Results: Addressing doping presents a true moral dilemma and is not a dichotomous process whereby athletes either report doping or do nothing. Instead, four options for addressing others’ PED use emerged: (1) confront PED user directly, (2) report to ‘someone’, (3) report to anti-doping ‘authorities’, or (4) ignore the behaviour. Underpinned by relational concerns and empathy, direct confrontation was participants’ preferred approach to addressing doping. Conclusion: Student-athletes are reluctant to blow the whistle on doping so the currently promoted method for reporting wrongdoing may be met with resistance. Instead, student-athletes indicate a willingness to personally confront PED users, which has the potential to protect both the doping athlete and whistleblower, while simultaneously reducing the presence of PEDs in sport. Thus, these findings serve to stimulate debate and discussion within anti-doping efforts regarding the possibility of confrontation being encouraged as an effective deterrent to sport doping

“The process isn’t a case of report it and stop”: Athletes’ lived experience of whistleblowing on doping in sport

Whistleblowing is effective for exposing doping in sport, garnering increased support and promotion within the global anti-doping community. However, limited attention has been afforded towards understanding the doping whistleblowing process. In response, the authors convey a sense of the whistleblowing context by using the actual words of whistleblowers to illuminate their experience. To achieve this aim, the authors have adopted a narrative approach. Three doping whistleblowers were interviewed regarding their lived experiences of whistleblowing on doping and the data has been represented in the form of one composite creative non-fiction story. The story narrates the whistleblowing experience as a process whereby individuals must (a) determine what they witnessed and experienced was doping, (b) make the decision and take action to report it, and (c) deal with the myriad of consequences and emotions. It also highlights the dilemma faced by whistleblowers who are likely equally compelled to adhere to the moral of loyalty and fairness; yet in this context they are unable to do both. Stemming from the story presented and the forms of retribution experienced, the authors offer practical suggestions for sporting organisations to address in order to empower others to whistleblow on doping in sport. Specifically, organisations should establish and implement whistleblowing policies that: (a) provide protection for whistleblowers, (b) mandate whistleblowing education, and (c) identify an independent person for individuals to seek guidance and support from before, during and following the act of whistleblowing

HER2-family signalling mechanisms, clinical implications and targeting in breast cancer.

Approximately 20 % of human breast cancers (BC) overexpress HER2 protein, and HER2-positivity is associated with a worse prognosis. Although HER2-targeted therapies have significantly improved outcomes for HER2-positive BC patients, resistance to trastuzumab-based therapy remains a clinical problem. In order to better understand resistance to HER2-targeted therapies in HER2-positive BC, it is necessary to examine HER family signalling as a whole. An extensive literature search was carried out to critically assess the current knowledge of HER family signalling in HER2-positive BC and response to HER2-targeted therapy. Known mechanisms of trastuzumab resistance include reduced receptor-antibody binding (MUC4, p95HER2), increased signalling through alternative HER family receptor tyrosine kinases (RTK), altered intracellular signalling involving loss of PTEN, reduced p27kip1, or increased PI3K/AKT activity and altered signalling via non-HER family RTKs such as IGF1R. Emerging strategies to circumvent resistance to HER2-targeted therapies in HER2-positive BC include co-targeting HER2/PI3K, pan-HER family inhibition, and novel therapies such as T-DM1. There is evidence that immunity plays a key role in the efficacy of HER-targeted therapy, and efforts are being made to exploit the immune system in order to improve the efficacy of current anti-HER therapies. With our rapidly expanding understanding of HER2 signalling mechanisms along with the repertoire of HER family and other targeted therapies, it is likely that the near future holds further dramatic improvements to the prognosis of women with HER2-positive BC

Understanding the implementation and effectiveness of a group-based early parenting intervention : a process evaluation protocol

BACKGROUND: Group-based early parenting interventions delivered through community-based services may be a potentially effective means of promoting infant and family health and wellbeing. Process evaluations of these complex interventions provide vital information on how they work, as well as the conditions which shape and influence outcomes. This information is critical to decision makers and service providers who wish to embed prevention and early interventions in usual care settings. In this paper, a process evaluation protocol for an early years parenting intervention, the Parent and Infant (PIN) program, is described. This program combines a range of developmentally-appropriate supports, delivered in a single intervention process, for parents and infants (0–2 years) and aimed at enhancing parental competence, strengthening parent-infant relationships and improving infant wellbeing and adjustment. METHODS: The process evaluation is embedded within a controlled trial and accompanying cost-effectiveness evaluation. Building from extant frameworks and evaluation methods, this paper presents a systematic approach to the process evaluation of the PIN program and its underlying change principles, the implementation of the program, the context of implementation and the change mechanisms which influence and shape parent and infant outcomes. We will use a multi-method strategy, including semi-structured interviews and group discussions with key stakeholders, documentary analysis and survey methodology. DISCUSSION: The integration of innovations into existing early years systems and services is a challenging multifaceted undertaking. This process evaluation will make an important contribution to knowledge about the implementation of such programs, while also providing an example of how theory-based research can be embedded within the evaluation of community-based interventions. We discuss the strengths of the research, such as the adoption of a collaborative approach to data collection, while we also identify potential challenges, including capturing and assessing complex aspects of the intervention. TRIAL REGISTRATION: ISRCTN17488830 (Date of registration: 27/11/15). This trial was retrospectively registered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12913-016-1737-3) contains supplementary material, which is available to authorized users

A Multicenter Observer Performance Study of 3D JPEG2000 Compression of Thin-Slice CT

The goal of this study was to determine the compression level at which 3D JPEG2000 compression of thin-slice CTs of the chest and abdomen–pelvis becomes visually perceptible. A secondary goal was to determine if residents in training and non-physicians are substantially different from experienced radiologists in their perception of compression-related changes. This study used multidetector computed tomography 3D datasets with 0.625–1-mm thickness slices of standard chest, abdomen, or pelvis, clipped to 12 bits. The Kakadu v5.2 JPEG2000 compression algorithm was used to compress and decompress the 80 examinations creating four sets of images: lossless, 1.5 bpp (8:1), 1 bpp (12:1), and 0.75 bpp (16:1). Two randomly selected slices from each examination were shown to observers using a flicker mode paradigm in which observers rapidly toggled between two images, the original and a compressed version, with the task of deciding whether differences between them could be detected. Six staff radiologists, four residents, and six PhDs experienced in medical imaging (from three institutions) served as observers. Overall, 77.46% of observers detected differences at 8:1, 94.75% at 12:1, and 98.59% at 16:1 compression levels. Across all compression levels, the staff radiologists noted differences 64.70% of the time, the resident’s detected differences 71.91% of the time, and the PhDs detected differences 69.95% of the time. Even mild compression is perceptible with current technology. The ability to detect differences does not equate to diagnostic differences, although perception of compression artifacts could affect diagnostic decision making and diagnostic workflow

The interaction of bacterial pathogens with platelets.

In recent years, the frequency of serious cardiovascular infections such as endocarditis has increased, particularly in association with nosocomially acquired antibiotic-resistant pathogens. Growing evidence suggests a crucial role for the interaction of bacteria with human platelets in the pathogenesis of cardiovascular infections. Here, we review the nature of the interactions between platelets and bacteria, and the role of these interactions in the pathogenesis of endocarditis and other cardiovascular diseases