The finiteness of the four dimensional antisymmetric tensor field model in a curved background

A renormalizable rigid supersymmetry for the four dimensional antisymmetric tensor field model in a curved space-time background is constructed. A closed algebra between the BRS and the supersymmetry operators is only realizable if the vector parameter of the supersymmetry is a covariantly constant vector field. This also guarantees that the corresponding transformations lead to a genuine symmetry of the model. The proof of the ultraviolet finiteness to all orders of perturbation theory is performed in a pure algebraic manner by using the rigid supersymmetry.Comment: 23 page

Geometric Laws of Vortex Quantum Tunneling

In the semiclassical domain the exponent of vortex quantum tunneling is dominated by a volume which is associated with the path the vortex line traces out during its escape from the metastable well. We explicitly show the influence of geometrical quantities on this volume by describing point vortex motion in the presence of an ellipse. It is argued that for the semiclassical description to hold the introduction of an additional geometric constraint, the distance of closest approach, is required. This constraint implies that the semiclassical description of vortex nucleation by tunneling at a boundary is in general not possible. Geometry dependence of the tunneling volume provides a means to verify experimental observation of vortex quantum tunneling in the superfluid Helium II.Comment: 4 pages, 2 figures, revised version to appear in Phys. Rev.

Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis

International audienceWithin the last decade, it became clear that oxygen contributes to the pathogenesis of neonatal brain damage, leading to neurocognitive impairment of prematurely born infants in later life. Recently, we have identified a critical role for receptor-mediated neuronal apoptosis in the immature rodent brain. However, the contribution of the intrinsic apoptotic pathway accompanied by activation of caspase-2 under hyperoxic conditions in the neonatal brain still remains elusive. Inhibition of caspases appears a promising strategy for neuroprotection. In order to assess the influence of specific caspases on the developing brain, we applied a recently developed pentapeptide-based group II caspase inhibitor (5-(2,6-difluorophenoxy)-3(R,S)-(2(S)-(2(S)-(3-methoxycarbonyl-2(S)-(3-m ethyl-2(S)-((quinoline-2-carbonyl)-amino)-butyrylamino)propionylamino) 3-methylbutyrylamino) propionylamino)-4-oxo-pentanoic acid methyl ester; TRP601). Here, we report that elevated oxygen (hyperoxia) triggers a marked increase in active caspase-2 expression, resulting in an initiation of the intrinsic apoptotic pathway with upregulation of key proteins, namely, cytochrome c, apoptosis protease-activating factor-1, and the caspase-independent protein apoptosis-inducing factor, whereas BH3-interacting domain death agonist and the anti-apoptotic protein B-cell lymphoma-2 are downregulated. These results coincide with an upregulation of caspase-3 activity and marked neurodegeneration. However, single treatment with TRP601 at the beginning of hyperoxia reversed the detrimental effects in this model. Hyperoxia-mediated neurodegeneration is supported by intrinsic apoptosis, suggesting that the development of highly selective caspase inhibitors will represent a potential useful therapeutic strategy in prematurely born infants. Cell Death and Disease (2012) 3, e250; doi:10.1038/cddis.2011.133; published online 12 January 201

The Dual Formulation of Cosmic Strings and Vortices

We study four dimensional systems of global, axionic and local strings. By using the path integral formalism, we derive the dual formulation of these systems, where Goldstone bosons, axions and missive vector bosons are described by antisymmetric tensor fields, and strings appear as a source for these tensor fields. We show also how magnetic monopoles attached to local strings are described in the dual formulation. We conclude with some remarks.Comment: 18 pages, CU-TP-588 and CERN-TH.6780/9

Localized D-dimensional global k-defects

We explicitly demonstrate the existence of static global defect solutions of arbitrary dimensionality whose energy does not diverge at spatial infinity, by considering maximally symmetric solutions described by an action with non-standard kinetic terms in a D+1 dimensional Minkowski space-time. We analytically determine the defect profile both at small and large distances from the defect centre. We verify the stability of such solutions and discuss possible implications of our findings, in particular for dark matter and charge fractionalization in graphene.Comment: 6 pages, published versio

Scaling Property of the global string in the radiation dominated universe

We investigate the evolution of the global string network in the radiation dominated universe by use of numerical simulations in 3+1 dimensions. We find that the global string network settles down to the scaling regime where the energy density of global strings, $\rho_{s}$, is given by $\rho_{s} = \xi \mu / t^2$ with $\mu$ the string tension per unit length and the scaling parameter, $\xi \sim (0.9-1.3)$, irrespective of the cosmic time. We also find that the loop distribution function can be fitted with that predicted by the so-called one scale model. Concretely, the number density, $n_{l}(t)$, of the loop with the length, $l$, is given by $n_{l}(t) = \nu/[t^{3/2} (l + \kappa t)^{5/2}]$ where $\nu \sim 0.0865$ and $\kappa$ is related with the Nambu-Goldstone(NG) boson radiation power from global strings, $P$, as $P = \kappa \mu$ with $\kappa \sim 0.535$. Therefore, the loop production function also scales and the typical scale of produced loops is nearly the horizon distance. Thus, the evolution of the global string network in the radiation dominated universe can be well described by the one scale model in contrast with that of the local string network.Comment: 18 pages, 9 figures, to appear in Phys. Rev.

Lagrangian evolution of global strings

We establish a method to trace the Lagrangian evolution of extended objects consisting of a multicomponent scalar field in terms of a numerical calculation of field equations in three dimensional Eulerian meshes. We apply our method to the cosmological evolution of global strings and evaluate the energy density, peculiar velocity, Lorentz factor, formation rate of loops, and emission rate of Nambu-Goldstone (NG) bosons. We confirm the scaling behavior with a number of long strings per horizon volume smaller than the case of local strings by a factor of $\sim$ 10. The strategy and the method established here are applicable to a variety of fields in physics.Comment: 5 pages, 2 figure

R-parity Conservation via the Stueckelberg Mechanism: LHC and Dark Matter Signals

We investigate the connection between the conservation of R-parity in supersymmetry and the Stueckelberg mechanism for the mass generation of the B-L vector gauge boson. It is shown that with universal boundary conditions for soft terms of sfermions in each family at the high scale and with the Stueckelberg mechanism for generating mass for the B-L gauge boson present in the theory, electric charge conservation guarantees the conservation of R-parity in the minimal B-L extended supersymmetric standard model. We also discuss non-minimal extensions. This includes extensions where the gauge symmetries arise with an additional U(1)_{B-L} x U(1)_X, where U(1)_X is a hidden sector gauge group. In this case the presence of the additional U(1)_X allows for a Z' gauge boson mass with B-L interactions to lie in the sub-TeV region overcoming the multi-TeV LEP constraints. The possible tests of the models at colliders and in dark matter experiments are analyzed including signals of a low mass Z' resonance and the production of spin zero bosons and their decays into two photons. In this model two types of dark matter candidates emerge which are Majorana and Dirac particles. Predictions are made for a possible simultaneous observation of new physics events in dark matter experiments and at the LHC.Comment: 38 pages, 7 fig

Neuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia

Inadequate delivery of oxygen to organisms during development can lead to cell dysfunction/death and life-long disabilities. Although the susceptibility of developing cells to low oxygen conditions changes with maturation, the cellular and molecular pathways that govern responses to low oxygen are incompletely understood. Here we show that developing Caenorhabditis elegans are substantially more sensitive to anoxia than adult animals and that this sensitivity is controlled by nervous system generated hormones (e.g., neuropeptides). A screen of neuropeptide genes identified and validated nlp-40 and its receptor aex-2 as a key regulator of anoxic survival in developing worms. The survival-promoting action of impaired neuropeptide signaling does not rely on five known stress resistance pathways and is specific to anoxic insult. Together, these data highlight a novel cell non-autonomous pathway that regulates the susceptibility of developing organisms to anoxia

The expression of Gli3, regulated by HOXD13, may play a role in idiopathic congenital talipes equinovarus

<p>Abstract</p> <p>Background</p> <p>Idiopathic congenital talipes equinovarus (ICTEV) is a congenital limb deformity. Based on extended transmission disequilibrium testing, <it>Gli-Kruppel family member 3 </it>(<it>Gli3</it>) has been identified as a candidate gene for ICTEV. Here, we verify the role of <it>Gli3 </it>in ICTEV development.</p> <p>Methods</p> <p>Using the rat ICTEV model, we analyzed the differences in <it>Gli3 </it>expression levels between model rats and normal control rats. We used luciferase reporter gene assays and ChIP/EMSA assays to analyze the regulatory elements of <it>Gli3</it>.</p> <p>Results</p> <p><it>Gli3 </it>showed higher expression levels in ICTEV model rats compared to controls (P < 0.05). We identified repressor and activator regions in the rat <it>Gli3 </it>promoter. The <it>Gli3 </it>promoter also contains two putative Hoxd13 binding sites. Using EMSA, the Hoxd13 binding site 2 was found to directly interact with Hoxd13 <it>in vitro</it>. ChIP assays of the Hoxd13-<it>Gli3 </it>promoter complex from a developing limb confirmed that endogenous Hoxd13 interacts with this region <it>in vivo</it>.</p> <p>Conclusion</p> <p>Our findings suggest that <it>HoxD13 </it>directly interacts with the promoter of <it>Gli3</it>. The increase of <it>Gli3 </it>expression in ICTEV model animal might result from the low expression of <it>HoxD13</it>.</p