HPC in Computational Micromechanics of Composite Materials

Proceedings of: Second International Workshop on Sustainable Ultrascale Computing Systems (NESUS 2015). Krakow (Poland), September 10-11, 2015.This work was supported by the European Regional Development Fund in the IT4Innovations Centre of Excellence project (CZ.1.05/1.1.00/02.0070) and the COST NESUS project with an additional CZ MEYS LD15105 support

Topographic inspection as a method of weld joint diagnostic

U radu se demonstrira topografsko ispitivanje u specifičnom kontekstu triju vrsta inspekcijskih metoda zavara od austenitnog nehrđajučeg željeza. Vizualna i metrološka kontrola provedena je tijekom ispitivanja zavarivanja TIG postupkom, primjenom ne-destruktivnih metoda: rendgensko ispitivanje, kompjuterizirana tomografija i profilometrija površine. Rad je reakcija na nedostatak informacija, posebice u području ne-destruktivnih metoda prikladnih za široku primjenu u praksi. U radu se prezentiraju prednosti i nedostaci analiziranih dijagnostičkih metoda i klasifikacija uobičajenih i specifičnih mana zavarenog spoja. Najvažnija neispravnost u praktičnim primjenama kod određivanja pouzdanosti zavarenog spoja su pukotine. Ova vrsta dijagnoze zasnovana je na dobivenim podacima o promatranom anizotropskom i nehomogenom volumenu u dijelu zavara pod utjecajem topline.The paper demonstrates a topographic inspection in the specific context of three kinds of inspection methods of austenitic stainless steel welds. Visual and metrological inspection was analysed during tungsten inert gas (TIG) welding tests, showing the non-destructive techniques: X-ray, computed tomography, and surface profilometry. The article is a response to the lack of information, especially in the area of non-destructive techniques suitable for wide practical application. The Paper presents advantages and drawbacks of the analysed diagnostic methods and a classification of conventional and specific welded joint flaws. The most important defect in practical applications determining reliability of a welded joint is cracks. This kind of diagnostic is based on the obtained information about anisotropic and inhomogeneous volume under consideration in the heat-affected zone of a weld

Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells

Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein significantly improves therapeutic options in chronic lymphocytic leukemia. However, some patients suffer from adverse effects mandating treatment discontinuation, and cases with TP53 defects more frequently experience early progression of the disease. Development of alternative therapeutic approaches is, therefore, of critical importance. Here we report details of the anti-chronic lymphocytic leukemia single-agent activity of MU380, our recently identified potent, selective, and metabolically robust inhibitor of checkpoint kinase 1. We also describe a newly developed enantioselective synthesis of MU380, which allows preparation of gram quantities of the substance. Checkpoint kinase 1 is a master regulator of replication operating primarily in intra-S and G2/M cell cycle checkpoints. Initially tested in leukemia and lymphoma cell lines, MU380 significantly potentiated efficacy of gemcitabine, a clinically used inducer of replication stress. Moreover, MU380 manifested substantial single-agent activity in both TP53-wild type and TP53-mutated leukemia and lymphoma cell lines. In chronic lymphocytic leukemia-derived cell lines MEC-1, MEC-2 (both TP53-mut), and OSU-CLL (TP53-wt) the inhibitor impaired cell cycle progression and induced apoptosis. In primary clinical samples, MU380 used as a single-agent noticeably reduced the viability of unstimulated chronic lymphocytic leukemia cells as well as those induced to proliferate by anti-CD40/IL-4 stimuli. In both cases, effects were comparable in samples harboring p53 pathway dysfunction (TP53 mutations or ATM mutations) and TP53-wt/ATM-wt cells. Lastly, MU380 also exhibited significant in vivo activity in a xenotransplant mouse model (immunodeficient strain NOD-scid IL2Rγnull) where it efficiently suppressed growth of subcutaneous tumors generated from MEC-1 cells

The Comet Interceptor Mission

Here we describe the novel, multi-point Comet Interceptor mission. It is dedicated to the exploration of a little-processed long-period comet, possibly entering the inner Solar System for the first time, or to encounter an interstellar object originating at another star. The objectives of the mission are to address the following questions: What are the surface composition, shape, morphology, and structure of the target object? What is the composition of the gas and dust in the coma, its connection to the nucleus, and the nature of its interaction with the solar wind? The mission was proposed to the European Space Agency in 2018, and formally adopted by the agency in June 2022, for launch in 2029 together with the Ariel mission. Comet Interceptor will take advantage of the opportunity presented by ESA's F-Class call for fast, flexible, low-cost missions to which it was proposed. The call required a launch to a halo orbit around the Sun-Earth L2 point. The mission can take advantage of this placement to wait for the discovery of a suitable comet reachable with its minimum ΔV capability of 600 ms-1. Comet Interceptor will be unique in encountering and studying, at a nominal closest approach distance of 1000 km, a comet that represents a near-pristine sample of material from the formation of the Solar System. It will also add a capability that no previous cometary mission has had, which is to deploy two sub-probes - B1, provided by the Japanese space agency, JAXA, and B2 - that will follow different trajectories through the coma. While the main probe passes at a nominal 1000 km distance, probes B1 and B2 will follow different chords through the coma at distances of 850 km and 400 km, respectively. The result will be unique, simultaneous, spatially resolved information of the 3-dimensional properties of the target comet and its interaction with the space environment. We present the mission's science background leading to these objectives, as well as an overview of the scientific instruments, mission design, and schedule

Flow Field Analysis Inside and at the Outlet of the Abrasive Head

This paper focuses on the investigation of a multiphase flow of water, air, and abrasive particles inside and at the outlet of the abrasive head with the help of computational fluid dynamics calculations and measurements. A standard abrasive head with a water nozzle hole diameter of 0.33 mm (0.013”) and an abrasive nozzle cylindrical hole diameter of 1.02 mm (0.04”) were used for numerical modelling and practical testing. The computed tomography provided an exact 3D geometrical model of the cutting head that was used for the creation of the model. Velocity fields of abrasive particles at the outlet of the abrasive head were measured and analysed using particle tracking velocimetry and, consequently, compared with the calculated results. The calculation model took the distribution of the abrasive particle diameters with the help of the Rosin-Rammler function in intervals of diameters from 150 to 400 mm. In the present study, four levels of water pressure (105, 194, 302, 406 MPa) and four levels of abrasive mass flow rate (100, 200, 300, 400 kg/min) were combined. The values of water pressures and hydraulic powers measured at the abrasive head inlet were used as boundary conditions for numerical modelling. The hydraulic characteristics of the water jet were created from the measured and calculated data. The calculated pressure distribution in the cylindrical part of the abrasive nozzle was compared with studies by other authors. The details of the experiments and calculations are presented in this paper

Flow Field Analysis Inside and at the Outlet of the Abrasive Head

This paper focuses on the investigation of a multiphase flow of water, air, and abrasive particles inside and at the outlet of the abrasive head with the help of computational fluid dynamics calculations and measurements. A standard abrasive head with a water nozzle hole diameter of 0.33 mm (0.013”) and an abrasive nozzle cylindrical hole diameter of 1.02 mm (0.04”) were used for numerical modelling and practical testing. The computed tomography provided an exact 3D geometrical model of the cutting head that was used for the creation of the model. Velocity fields of abrasive particles at the outlet of the abrasive head were measured and analysed using particle tracking velocimetry and, consequently, compared with the calculated results. The calculation model took the distribution of the abrasive particle diameters with the help of the Rosin-Rammler function in intervals of diameters from 150 to 400 mm. In the present study, four levels of water pressure (105, 194, 302, 406 MPa) and four levels of abrasive mass flow rate (100, 200, 300, 400 kg/min) were combined. The values of water pressures and hydraulic powers measured at the abrasive head inlet were used as boundary conditions for numerical modelling. The hydraulic characteristics of the water jet were created from the measured and calculated data. The calculated pressure distribution in the cylindrical part of the abrasive nozzle was compared with studies by other authors. The details of the experiments and calculations are presented in this paper.</jats:p