An Ontological Basis for Design Methods

This paper presents a view of design methods as process artefacts that can be represented using the function-behaviour-structure (FBS) ontology. This view allows identifying five fundamental approaches to methods: black-box, procedural, artefact-centric, formal and managerial approaches. They all describe method structure but emphasise different aspects of it. Capturing these differences addresses common terminological confusions relating to methods. The paper provides an overview of the use of the fundamental method approaches for different purposes in designing. In addition, the FBS ontology is used for developing a notion of prescriptiveness of design methods as an aggregate construct defined along four dimensions: certainty, granularity, flexibility and authority. The work presented in this paper provides an ontological basis for describing, understanding and managing design methods throughout their life cycle. Keywords: Design Methods; Function-Behaviour-Structure (FBS) Ontology; Prescriptive Design Knowledge</p

The fatherhood of God from Origen to Athanasius

Reviewed Book: Widdicombe, Peter. The fatherhood of God from Origen to Athanasius. Oxford: Clarendon Pr; [S.l.]: Oxford Univ Pr, 1994. Oxford theological monographs

Rationale in Semi-Structured Processes

Abstract. This paper argues that an explicit account of rationale is essential for the effective management and evolution of semi-structured processes. Our approach is based on a view of semi-structured process models as unfinished products whose design is implicitly completed through their execution by process model users. The resulting refinements and modifications of the process models are instances of user-driven design innovation. Our framework shows how rationale can explain a user’s individual execution decisions, as a basis for process modelers to improve the original process specifications. We propose and illustrate a modeling approach using the FBS ontology

The Internet-of-Things Meets Business Process Management: Mutual Benefits and Challenges

The Internet of Things (IoT) refers to a network of connected devices collecting and exchanging data over the Internet. These things can be artificial or natural, and interact as autonomous agents forming a complex system. In turn, Business Process Management (BPM) was established to analyze, discover, design, implement, execute, monitor and evolve collaborative business processes within and across organizations. While the IoT and BPM have been regarded as separate topics in research and practice, we strongly believe that the management of IoT applications will strongly benefit from BPM concepts, methods and technologies on the one hand; on the other one, the IoT poses challenges that will require enhancements and extensions of the current state-of-the-art in the BPM field. In this paper, we question to what extent these two paradigms can be combined and we discuss the emerging challenges

Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity.

L'article final de l'éditeur contient 9 pages. Le manuscrit accepté contient 32 pages.International audienceMutations of the TMPRSS6 gene, which encodes Matriptase-2, are responsible for iron-refractory iron-deficiency anemia. Matriptase-2 is a transmembrane protease that downregulates hepcidin expression. We report one frameshift (p.Ala605ProfsX8) and four novel missense mutations (p.Glu114Lys, p.Leu235Pro, p.Tyr418Cys, p.Pro765Ala) found in IRIDA patients. These mutations lead to changes in both the catalytic and noncatalytic domains of Matriptase-2. Analyses of the mutant proteins revealed a reduction of autoactivating cleavage and the loss of N-Boc-Gln-Ala-Arg-p-nitroanilide hydrolysis. This resulted either from a direct modification of the active site or from the lack of the autocatalytic cleavage that transforms the zymogen into an active protease. In a previously described transfection assay measuring the ability of Matriptase-2 to repress the hepcidin gene (HAMP) promoter, all mutants retained some, if not all, of their transcriptional repression activity. This suggests that caution is called for in interpreting the repression assay in assessing the functional relevance of Matriptase-2 substitutions. We propose that Matriptase-2 activity should be measured directly in the cell medium of transfected cells using the chromogenic substrate. This simple test can be used to determine whether a sequence variation leading to an amino acid substitution is functionally relevant or not