Case Report Inguinal Hernia Containing Uterus, Fallopian Tube, and Ovary in a Premature Newborn

A female infant weighing 2,200 g was delivered at 34 weeks of gestation by vaginal delivery. She presented with an irreducible mass in the left inguinal region at 32 days of age. An ultrasonography (US) was performed and an incarcerated hernia containing uterus, fallopian tube, and ovary was diagnosed preoperatively. Surgery was performed through an inguinal approach; the uterus, fallopian tube, and ovary were found in the hernia sac. High ligation and an additional repair of the internal inguinal ring were performed. Patent processus vaginalis was found during contralateral exploration and also closed. The postoperative course was uneventful. After one year of follow-up, there have been no signs of recurrence

Inguinal Hernia Containing Uterus, Fallopian Tube, and Ovary in a Premature Newborn

A female infant weighing 2,200 g was delivered at 34 weeks of gestation by vaginal delivery. She presented with an irreducible mass in the left inguinal region at 32 days of age. An ultrasonography (US) was performed and an incarcerated hernia containing uterus, fallopian tube, and ovary was diagnosed preoperatively. Surgery was performed through an inguinal approach; the uterus, fallopian tube, and ovary were found in the hernia sac. High ligation and an additional repair of the internal inguinal ring were performed. Patent processus vaginalis was found during contralateral exploration and also closed. The postoperative course was uneventful. After one year of follow-up, there have been no signs of recurrence

Solid pseudopapillary tumor of the pancreas: a rare entity

Solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm in children that mainly occurs in young females. We herein report a rare case of SPT arising from the tail of the pancreas. A 13-year-old girl was admitted to our clinic with abdominal pain and anorexia. A mass was palpated on the physical examination. A 90x72 mm, encapsulated, heterogeneous mass with solid and cystic components was defined on computerized tomography (CT). Distal pancreatectomy was performed during the operation. Histopathological examination revealed that the tumor was a SPT with negative surgical margins. A six-month follow-up after surgical resection showed no evidence of recurrent disease. SPT should always be considered in the differential diagnosis in a young female with a palpable mass

Incarcerated uterus and bilateral ovaries in a premature female infant inguinal hernia

We present a case of an inguinal hernia in a premature female infant containing the uterus and bilateral adnexa. This was diagnosed on ultrasound and underwent operative repair. The viable hernia contents were reduced laparoscopically, however the sliding nature of the hernia warranted open repair. Surgery was converted to the traditional inguinal approach and the hernia was successfully repaired with high ligation of the sac and additional closure of the internal ring. Post-operative course was unremarkable

Anticarcinogenic effects of halofuginone on lung-derived cancer cells

Malignant mesothelioma is a rare but aggressive form of malignancy, which is difficult to diagnose and is resistant to current chemotherapeutic treatment options. Molecular techniques have been used to investigate the mechanisms of action and the beneficial therapeutic effects of halofuginone (HF) in several cancers but not malignant mesotheliomas. In this study, the antiproliferative and apoptotic effects of HF were investigated through its ability to deregulate EGFR downstream signalling cascade proteins in the pathologically aggressive malignant mesothelioma and non-small-cell lung cancer cells. We showed that administration of HF at nanomolar concentrations induced a dose-dependent reduction in the viability of cancer cells, made cell cycle arrest, inhibited proliferation of cancer cells via STAT3 and ERK1/2 pathways and triggered the apoptotic cascade via p38MAPK. We demonstrated that the apoptotic cell death mechanism was mediated by enhanced activation of caspase-3 and concomitant PARP cleavage, downregulation of Bcl-2 and upregulation of Bax in both malignant mesothelioma and lung cancer cells. In particular, we demonstrated that cancer cells were more sensitive to HF treatment than normal mesothelial cells. Taken together, this study suggests that HF exerts its anticancer effects in lung-derived cancers by targeting signal transduction pathways mainly through deregulation of ERK1/2, STAT3 and p38MAPK to reduce cancer cell viability, induce cell cycle arrest and apoptotic cell death. Thus, HF might be considered as a potential agent against malignant mesothelioma and/or lung cancer cells

The effect of dorsal dartos flaps on complication rates in hypospadias repair: A randomised prospective study

Aim This study prospectively analysed the effect of using a dartos flap on the complication rates of TIPU (tubularised incised plate urethroplasty) in hypospadias repair. Material and methods Patients having TIPU repair for hypospadias at our university hospital between January 2010 and August 2013 were prospectively divided into two groups. Group 1 had TIPU repair with dorsal dartos flap, whereas group 2 had flapless repair. At the end of the follow-up period (mean 23.3 m, median 20.2), complication rates were compared between two groups. Results There were 107 patients in each group. The overall complication rate was 9.3%. The complication rates were 12.1% in group 1 (6 glans dehiscence and 7 fistula) and 6.5% in group 2 (2 glans dehiscence and 5 fistula). The differences between complication rates and fistula were statistically insignificant (p = 0.2511 and p = 0.7710, respectively). Conclusion Our prospective and randomised study found that the use of dartos flaps in hypospadias offers no statistically significant advantage over flapless repair for complication rates

Is an interval appendectomy still necessary in perforated appendicitis with inflammatory mass/abcess

We reviewed our experience in non-operative management without an interval appendectomy (IA), for patients who presented with perforated appendicitis with an abcess or inflammatory mass from November 2012 to November 2017 retrospectively. The data included age, sex, duration of symptoms, presence of appendicolith/ abcess on CT imaging, WBC and CRP levels, antibiotic treatment, fever at presentation, percutan drainage procedure and complications, recurrent abscess, total length of hospitalization, follow-up period. A total of 32 patients were treated with nonoperative management during the study period. Nonoperative management without an IA was successful in 31 patients (96%). Study patients included were admitted to the surgical ward for observation. The mean age of the patients was 9.74±3.55 years. 19 male and 13 female patients were included in the study. The mean duration of symptoms was 8.75±4.69 days. The mean number of Ct scans was 1.21±0.42 per patient. Percutan drainage was performed in 10 patients. The mean of WBC levels at presentation was 19030.00±7192.24 cells/μL and CRP levels was 156.61±94.23 mg/dl. Intravenous piperacillin-tazobactam (Tazosin®, Pfizer, New York, NY) were given 400 mg/kg/day in four divided doses. Diet were started to the patients who were afebrile and had diminished abdominal pain during observation. The mean length of hospitalization was 13.03±5.82 days. The mean duration of follow-up period 34.65±20.48 months. Nonoperative management without IA is a preferable choice for perforated appendicitis with abcess or mass