Asset Validation for Mobile Game Development

This thesis explores the development of an asset validation framework for Unity-based mobile games. The motivation for the work arises from the need to ensure technical quality and consistency in large-scale game projects, where asset validation is essential for maintaining performance, minimizing build size, and avoiding visual or runtime issues. Manually validating assets is time-consuming, error-prone, and difficult to scale across teams and workflows—especially when dealing with thousands of game assets. The tool developed in this project enables automated validation by leveraging a modular architecture and a hierarchical configuration system. Validation rules are defined as stand-alone modules, which can be configured per folder using external files. The system supports both manual use through the Unity Editor and automated execution through Unity’s Test Runner and CI/CD pipelines. This thesis documents the key architectural decisions behind the framework, including interface-driven design, runtime module discovery using reflection, and the separation of validation tasks into isolated queues. The system is designed to be scalable, extensible, and user-friendly for both technical and non-technical team members. As a result, the tool enables real-time feedback during development, minimizes manual quality assurance effort, and ensures consistent asset standards across projects. The project demonstrates how automation and thoughtful tool design can improve production workflows in mobile game development. Future development opportunities include expanding validation rule sets, improving test case generation in CI, and introducing caching or hashing mechanisms for incremental validationTässä opinnäytetyössä käsitellään Unity-pohjaisiin mobiilipeleihin suunnitellun assettien validointikehyksen kehittämistä. Työn lähtökohtana on tarve varmistaa tekninen laatu ja yhdenmukaisuus laajoissa peliprojekteissa, joissa assettien validointi on keskeistä suorituskyvyn ylläpitämiseksi, rakennuskokojen hallitsemiseksi ja visuaalisten tai ajonaikaisten virheiden estämiseksi. Manuaalinen validointi on työlästä, altis virheille ja vaikeasti skaalattavissa tiimien ja työvaiheiden välillä – erityisesti, kun käsitellään tuhansia pelisisältöjä. Projektissa kehitetty työkalu mahdollistaa validoinnin automatisoinnin hyödyntämällä modulaarista arkkitehtuuria ja hierarkkista konfiguraatiorakennetta. Validointisäännöt määritellään erillisinä moduuleina, jotka voidaan kohdistaa hakemistokohtaisesti ulkoisten tiedostojen avulla. Järjestelmä tukee sekä manuaalista käyttöä Unity-editorissa että automaattista suoritusta testityökalujen ja julkaisuprosessien osana. Opinnäytetyössä kuvataan tärkeimmät arkkitehtuurilliset ratkaisut, kuten käyttöliittymäsidonnainen suunnittelu, ajonaikainen moduulien tunnistus reflektiolla sekä validointitehtävien eriyttäminen omiin käsittelyjonoihinsa. Järjestelmä on suunniteltu skaalautuvaksi, laajennettavaksi ja helposti käytettäväksi sekä teknisille että ei-teknisille tiimin jäsenille. Työkalu tarjoaa kehityksen aikana reaaliaikaista palautetta, vähentää manuaalisen laadunvarmistuksen tarvetta ja varmistaa yhtenäiset sisältöstandardit projekteissa. Projektin tulokset osoittavat, kuinka automaatio ja harkittu työkalusuunnittelu voivat parantaa tuotantoprosesseja mobiilipelien kehityksessä. Jatkokehitysmahdollisuuksia ovat muun muassa validointisääntöjen laajentaminen, testitapausten parantaminen sekä välimuistiin ja hajautustekniikoihin perustuvan inkrementaalisen validoinnin tukeminen

Morganella morganii bloodstream infection affects the elderly in close contact with healthcare

BackgroundWe aimed to fill the gaps of knowledge concerning incidence rates and temporal trend, clinical features and risk factors for death for M. morganii bloodstream infections in south Sweden.MethodsThis was an observational, population-based study including all patients with at least one blood culture positive for Morganella morganii between 2013-2023 in Skåne, south Sweden.ResultsA total of 211 episodes of Morganella morganii bloodstream infection in 201 patients were registered during the study period. A urinary tract focus BSI was associated with reduce risk of 90-day mortality (p = 0.0029) whereas a primary BSI was associated with 90-day mortality (p = 0.0112). A multivariate analysis including age, gender, CCI, and immunosuppression revealed that higher CCI (OR 1.25, 95% CI 1.07-1.47, p = 0.0059) and immunosuppression (OR 3.26, 95% CI 1.45-7.47, p = 0.0045) was independently associated with all-cause mortality.ConclusionMorganella morganii bloodstream infection is the elderly's disease, most often acquired in individuals with comorbidities that are in close contact with healthcare. A urinary tract focus was associated with reduced risk of 90-day mortality, and higher CCI and immunosuppression was associated with 90-day all-cause mortality in a multivariate analysis

Hur förändras kundvärdet när nyhetsmedia digitaliseras? -En undersökning om dagstidningsbranschens övergång till digitala upplagor

Syfte: Syftet med vår uppsats är att utifrån konsumentens synvinkel undersöka vad som skapar kundvärde i det digitala erbjudandet genom att ta reda på hur konsumtionsvanorna skiljer sig åt mellan den digitala upplagan och pappersupplagan av dagstidningen för att ge ett kvalitativt bidrag till kundvärdesforskningen. Metod: Uppsatsen baseras på en kvalitativ studie som har genomförts utifrån ett hermeneutiskt förhållningssätt. Ansatsen är deduktiv med induktiva inslag. Primärdatan bygger på semistrukturerade intervjuer och sekundärdatan är främst hämtad från vetenskapliga artiklar. Teoretiska perspektiv: Uppsatsens teoretiska referensram åskådliggör grundläggande teorier om kundvärde samt forskning kring adoptionsprocesser och integrerade erbjudanden. Empiri: Empirin bygger på sexton stycken semistrukturerade intervjuer med personer som har erfarenhet av dagstidningsläsande. Resultat: Vad som skapar kundvärde i det digitala erbjudandet skiljer sig från värdeskapandet i pappersformatet av dagstidningen. Även om den digitala dagstidningen många gånger lovordas för bland annat sin omedelbara tillgänglighet och sitt aktuella nyhetsflöde är en majoritet av intervjupersonerna än idag ovilliga att betala för den. Utifrån de empiriska fynden har sedan en sammanfattande kundvärdesmodell skapats för att visa vad mervärdet i det digitala sammanhanget beror på. Modellen är baserad på tidigare modeller om kundvärde, men har anpassats till den digitala dagstidningen som informationsprodukt.Title: How does customer perceived value change as traditional media turns digital? - An exploratory study of the digital transition of newspapers. Key words: customer perceived value, consumer perspective, digital media, online value, offline value. Purpose: The main purpose of this thesis is to examine the customer’s value perception of the daily newspapers and how the consumption patterns differ between the physical and the digital format. Methodology: A qualitative study has been conducted using a hermeneutic approach. This approach is deductive while incorporating inductive elements. The raw data is based on sixteen semistructured interviews whereas the secondary data is derived from scientific publications. Theoretical perspectives: The theoretical framework is firstly based on the basic theories of customer perceived value (CPV). Secondly, this is combined with the specific elements of the physical and digital format in order to investigate the impact of this on CPV. Empirical foundation: The empirical foundation is based on sixteen semistructured interviews with both female and male respondents in various ages and with different professions. Conclusions: The customers’ perceived value of daily newspapers differ depending on which format that is under consideration. The digital format is, in contrast to the physical format, appreciated because of its immediate availability and for its constantly updated news content. However, these benefits tend to be inadequate to increase customers’ willingness to pay for the online content. The additional value that is requested by the customers in the digital newspaper is further developed in a model that is based on the empirical findings combined with previous models of customer value

Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas

<p>Abstract</p> <p>Background</p> <p>Loss of heterozygosity of chromosome 10q26 has been shown to be associated with the aggressiveness of astrocytic tumors (or astrocytomas), but the responsible gene(s) residing in this region has not been fully identified. The <it>BCCIP </it>gene is located at chromosome 10q26. It encodes a BRCA2 and CDKN1A (p21) interacting protein. Previous studies have shown that down-regulation of BCCIP impairs recombinational DNA repair, G1/S cell cycle checkpoint, p53 trans-activation activity, cytokinesis, and chromosome stability, suggesting a potential role of <it>BCCIP </it>in cancer etiology. In this study, we investigated whether <it>BCCIP </it>is altered in astrocytomas.</p> <p>Methods</p> <p>Genomic DNA from 45 cases of grade IV astrocytic tumor (glioblastoma) tissues and 12 cases of normal tissues were analyzed by quantitative PCR. The BCCIP protein expression in 96 cases of grade II–IV astrocytic tumors was detected by immunohistochemistry (IHC). IHC staining of glial fibrillary acid protein (GFAP), a marker for astrocytic cells, was used to identify cells of the astrocytic lineage.</p> <p>Results</p> <p>We found that BCCIP protein is expressed in normal cells with positive staining of GFAP. However, BCCIP protein expression was not detectable in ~45% of all astrocytic tumors, and in > 60% in the grade IV glioblastoma. About 45% glioblastoma have significant (p < 0.01) reduction of <it>BCCIP </it>gene copy number when compared to normal DNA. Furthermore, the frequency of lacking BCCIP expression is associated with the aggressiveness of astrocytic tumors.</p> <p>Conclusion</p> <p>Our data implicate a role of BCCIP in astrocytic tumorigenesis, and lack of <it>BCCIP </it>may be used as a marker for astrocytomas.</p

Update of complications and functional outcome of the ileo-pouch anal anastomosis: overview of evidence and meta-analysis of 96 observational studies

Item does not contain fulltextOBJECTIVE: The objective of this study is to provide a comprehensive update of the outcome of the ileo-pouch anal anastomosis (IPAA). DATA SOURCES: An extensive search in PubMed, EMBASE, and The Cochrane Library was conducted. STUDY SELECTION AND DATA EXTRACTION: All studies published after 2000 reporting on complications or functional outcome after a primary open IPAA procedure for UC or FAP were selected. Study characteristics, functional outcome, and complications were extracted. DATA SYNTHESIS: A review with similar methodology conducted 10 years earlier was used to evaluate developments in outcome over time. Pooled estimates were compared using a random-effects logistic meta-analyzing technique. Analyses focusing on the effect of time of study conductance, centralization, and variation in surgical techniques were performed. RESULTS: Fifty-three studies including 14,966 patients were included. Pooled rates of pouch failure and pelvic sepsis were 4.3% (95% CI, 3.5-6.3) and 7.5% (95% CI 6.1-9.1), respectively. Compared to studies published before 2000, a reduction of 2.5% was observed in the pouch failure rate (p = 0.0038). Analysis on the effect of the time of study conductance confirmed a decline in pouch failure. Functional outcome remained stable over time, with a 24-h defecation frequency of 5.9 (95% CI, 5.0-6.9). Technical surgery aspects did not have an important effect on outcome. CONCLUSION: This review provides up to date outcome estimates of the IPAA procedure that can be useful as reference values for practice and research. It is also shows a reduction in pouch failure over time.1 juli 201

Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas

The PTEN gene, located on 10q23.3, has recently been described as a candidate tumour suppressor gene that may be important in the development of advanced cancers, including gliomas. We have investigated mutation in the PTEN gene by direct sequence analysis of PCR products amplified from samples microdissected from 19 low grade (WHO Grade I and II) and 27 high grade (WHO grade III and IV) archival, formalin-fixed, paraffin-embedded gliomas. Eleven genetic variants in ten tumours have been identified. Eight of these are DNA sequence changes that could affect the encoded protein and were present in 0/2 pilocytic astrocytomas, 0/2 oligoastrocytomas, 0/1 oligodendroglioma, 0/14 astrocytomas, 3/13 (23%) anaplastic astrocytomas and 5/14 (36%) glioblastomas. PTEN mutations were found exclusively in high grade gliomas; this finding was statistically significant. Only two of the PTEN genetic variants have been reported in other studies; two of the genetic changes are in codons in which mutations have not been found previously. The results of this study indicate that mutation in the PTEN gene is present only in histologically more aggressive gliomas, may be associated with the transition from low histological grade to anaplasia, but is absent from the majority of high grade gliomas. © 1999 Cancer Research Campaig

High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours

Diffusely infiltrative astrocytic tumours are the most common neoplasms in the human brain. To localise putative tumour suppressor loci that are involved in low-grade astrocytomas, we performed high-resolution genome-wide allelotype analysis on 17 fibrillary astrocytomas. Non-random allelic losses were identified on chromosomal arms 10p (29%), 10q (29%), 14q (35%), 17p (53%), and 19q (29%), with their respective common regions of deletions delineated at 10p14-15.1, 10q25.1-qter, 14q212.2-qer, 17p11.2-pter and 19q12-13.4. These results suggest that alterations of these chromosomal regions play important roles in the development of astrocytoma. We also allelotyped 21 de novo glioblastoma multiforme with an aim to unveil genetic changes that are common to both types of astrocytic tumours. Non-random allelic losses were identified on 9p (67%), 10p (62%), 10q (76%), 13q (60%), 14q (50%), and 17p (65%). Allelic losses of 10p, 10q, 14q and 17p were common genetic alterations detectable in both fibrillary astrocytomas and glioblastoma multiforme. In addition, two common regions of deletions on chromosome 14 were mapped to 14q22.3-32.1 and 14q32.1-qter, suggesting the presence of two putative tumour suppressor genes. In conclusion, our comprehensive allelotype analysis has unveiled several critical tumour suppressor loci that are involved in the development of fibrillary astrocytomas and glioblastoma multiforme. Although these two types of brain tumours are believed to evolve from different genetic pathways, they do share some common genetic changes. Our results indicate that deletions of chromosome 14q is a recurrent genetic event in the development of astrocytoma and highlight the subchromosomal regions on this chromosome that are likely to contain putative tumour suppressor genes involved in the oncogenesis of astrocytic tumours

Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma

We examined a panel of sporadic breast carcinomas for loss of heterozygosity (LOH) in a 10-cM interval on chromosome 10 known to encompass the PTEN gene. We detected allele loss in 27 of 70 breast tumour DNAs. Fifteen of these showed loss limited to a subregion of the area studied. The most commonly deleted region was flanked by D10S215 and D10S541 and encompasses the PTEN locus. We used a combination of denaturing gradient gel electrophoresis and single-strand conformation polymorphism analyses to investigate the presence of PTEN mutations in tumours with LOH in this region. We did not detect mutations of PTEN in any of these tumours. Our data show that, in sporadic breast carcinoma, loss of heterozygosity of the PTEN locus is frequent, but mutation of PTEN is not. These results are consistent with loss of another unidentified tumour suppressor in this region in sporadic breast carcinoma. © 1999 Cancer Research Campaig

ORACLE SUPPORT Can it be made more intelligent?

Knowledge and accordingly the management of knowledge have been increasingly important to organizations in general and knowledge-intensive organizations in particular. The organization that this thesis if focusing on, the Oracle Support department of Gothenburg is an example of such a knowledge-intensive organization, where the employees’ and their knowledge and competence are the central assets. The purpose of this master thesis is to investigate and highlight the potential benefits Information and Communication Technology (ICT) can have on the management of knowledge at Oracle Support. Furthermore, the thesis discusses the related but somewhat different concepts of data, information, and knowledge. In addition various ICT and their influence on an organization’s management of knowledge are introduced. Technologies that are discussed are for example knowledge repositories, intranet-related tools and systems, as well as intelligent agents. When creating the interview guideline, we used an ethnographical approach, thus enabling the authors to construct and put the right questions and consequently receive answers of high value and relevance. The research gave the authors valuable insights as well as specific design proposals. The research results as well as the analysis that the five ICT-dimensions from the theoretical chapter resulted in, made it the possible for the authors to answer the problem definition, “are intelligent agents capable of improving the support process at Oracle?” affirmatively. Consequently two concrete design proposals regarding the implementation of intelligent agents were created based on the sub questions: where should they be implemented and how are they supposed to function? The first design proposal was to create a customer specific intelligent agent in Metalink, with a filter function. The second proposal was to construct intelligent agent support for the employees, thus facilitating the search and transfer for and of information and knowledge