Analysis And Design Of Multi-user System ABC

Personal Computer (PC) at the current rapid development. Not only used for private purposes but also for business. To meet the needs of data communications, and now PCs can be linked in a network (network) are integrated in a limited location, called Local Area Networks (LAN). The concept of multi-user system is used by banks in the process of saving the ABC. But whether multi-user LAN system has many advantages compared with the mini machine? Authors in this study tried to owned by the Local Area Network (LAN). The author conducted research in several stages, library research, data collection, data processing and analysis of research

A survey of exploratory search systems based on LOD resources

The fact that the existing Web allows people to effortlessly share data over the Internet has resulted in the accumulation of vast amounts of information available on the Web.Therefore, a powerful search technology that will allow retrieval of relevant information is one of the main requirements for the success of the Web which is complicated further due to use of many different formats for storing information. Semantic Web technology plays a major role in resolving this problem by permitting the search engines to retrieve meaningful information. Exploratory search system, a special information seeking and exploration approach, supports users who are unfamiliar with a topic or whose search goals are vague and unfocused to learn and investigate a topic through a set of activities. In order to achieve exploratory search goals Linked Open Data (LOD) can be used to help search systems in retrieving related data, so the investigation task runs smoothly.This paper provides an overview of the Semantic Web Technology, Linked Data and search strategies, followed by a survey of the state of the art Exploratory Search Systems based on LOD.Finally the systems are compared in various aspects such as algorithms, result rankings and explanations

Dynamics of entropy perturbations in assisted dark energy with mixed kinetic terms

We study dynamics of entropy perturbations in the two-field assisted dark energy model. Based on the scenario of assisted dark energy, in which one scalar field is subdominant compared with the other in the early epoch, we show that the entropy perturbations in this two-field system tend to be constant on large scales in the early epoch and hence survive until the present era for a generic evolution of both fields during the radiation and matter eras. This behaviour of the entropy perturbations is preserved even when the fields are coupled via kinetic interaction. Since, for assisted dark energy, the subdominant field in the early epoch becomes dominant at late time, the entropy perturbations can significantly influence the dynamics of density perturbations in the universe. Assuming correlations between the entropy and curvature perturbations, the entropy perturbations can enhance the integrated Sachs-Wolfe (ISW) effect if the signs of the contributions from entropy perturbations and curvature perturbations are opposite after the matter era, otherwise the ISW contribution is suppressed. For canonical scalar field the effect of entropy perturbations on ISW effect is small because the initial value of the entropy perturbations estimated during inflation cannot be sufficiently large. However, in the case of k-essence, the initial value of the entropy perturbations can be large enough to affect the ISW effect to leave a significant imprint on the CMB power spectrum.Comment: 25 pages, 8 figures, revised version, accepted for publication in JCA

Predictors of upper limb disorders among a public university workers in Malaysia

Background: Upper Limb Disorder (ULD) includes a wide range of musculoskeletal diseases and syndromes, which are usually associated with pain and discomfort. The major forms of musculoskeletal disease that account for significant work-related morbidity include upper limb disorders. The main objective of this study was to determine the prevalence and associated factors of upper limb disorders among a public university worker. Methodology: A cross sectional study design and simple random sampling was used to select six out of fifteen faculties. A total 271 participants were selected from the list of workers name during 20th of May 2014 to 1st of September 2014. Data were collected by face-to-face interview based on standardizes Nordic questionnaire. Weight was measured with a digital (TANITA Weighing Scale) and height by using (SECA206 bodymeter). Results: The results of this study showed that the response rate was 86%, the prevalence of ULDs among staffs of public university in Malaysia was 67.2% in different body regions, while neck had the highest prevalence 147 (54.2%) and elbows had the lowest prevalence 35 (13%). In addition, significant association were found between ULDs with age, smoking, BMI, exercise and duration of employment (P<0.05). Logistic regression analysis indicated that BMI and exercise were significant predictors of ULDs. Conclusion: The prevalence of upper limb disorders among public university workers is high (67.2%). The major risk factors responsible for ULDs was BMI and exercise among public university workers, so workers should be educated on how to maintain an optimal BMI through the consumption of appropriate meals and regular exercise recommended in order to prevent ULDs and other related musculoskeletal problems

The Experience of Implementation of Innovative Technology of Quarry Waste Water Purifying in Kuzbass Open Pit

Among all industries in Kuzbass (Western Siberia, Russia) the coal industry provides the most environmental threat. However, the construction of new and maintenance of existing open pit mines do not often correspond to the tasks of improving the environmental safety of surface mining. So the article describes the use of innovative quarry waste water purifying technology implemented in Kuzbass open pit mine "Shestaki". This technology is based on using artificial filter arrays made of overburden rock

CELL DEATH AND AUTOPHAGY: CYTOKINES, DRUGS, AND NUTRITIONAL FACTORS

Cellsmay use multiple pathways to commit suicide. In certain contexts, dying cells generate large amounts of autophagic vacuoles and clear large proportions of their cytoplasm, before they finally die, as exemplified by the treatment of human mammary carcinoma cells with the anti-estrogen tamoxifen (TAM, ≤1 M). Protein analysis during autophagic cell death revealed distinct proteins of the nuclear fraction including GST- and some proteasomal subunit constituents to be affected during autophagic cell death. Depending on the functional status of caspase-3, MCF-7 cells may switch between autophagic and apoptotic features of cell death [Fazi, B., Bursch,W., Fimia, G.M., Nardacci R., Piacentini, M., Di Sano, F., Piredda, L., 2008. Fenretinide induces autophagic cell death in caspase-defective breast cancer cells. Autophagy 4(4), 435–441]. Furthermore, the self-destruction of MCF-7 cells was found to be completed by phagocytosis of cell residues [Petrovski, G., Zahuczky, G., Katona, K., Vereb, G., Martinet,W., Nemes, Z., Bursch,W., Fésüs, L., 2007. Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes. Cell Death Diff. 14 (6), 1117–1128]. Autophagy also constitutes a cell’s strategy of defense upon cell damage by eliminating damaged bulk proteins/organelles. This biological condition may be exemplified by the treatment of MCF-7 cells with a necrogenic TAM-dose (10 M), resulting in the lysis of almost all cells within 24 h. However, a transient (1 h) challenge of MCF-7 cells with the same dose allowed the recovery of cells involving autophagy. Enrichment of chaperones in the insoluble cytoplasmic protein fraction indicated the formation of aggresomes, a potential trigger for autophagy. In a further experimental model HL60 cells were treated with TAM, causing dose-dependent distinct responses: 1–5 MTAM, autophagy predominant; 7–9 M, apoptosis predominant; 15 M, necrosis. These phenomena might be attributed to the degree of cell damage caused by tamoxifen, either by generating ROS, increasing membrane fluidity or forming DNA-adducts. Finally, autophagy constitutes a cell’s major adaptive (survival) strategy in response to metabolic challenges such as glucose or amino acid deprivation, or starvation in general. Notably, the role of autophagy appears not to be restricted to nutrient recycling in order to maintain energy supply of cells and to adapt cell(organ) size to given physiological needs. For instance, using a newly established hepatoma cell line HCC-1.2, amino acid and glucose deprivation revealed a pro-apoptotic activity, additive to TGF- 1. The proapoptotic action of glucose deprivation was antagonized by 2-deoxyglucose, possibly by stabilizing the mitochondrial membrane involving the action of hexokinase II. These observations suggest that signaling cascades steering autophagy appear to provide links to those regulating cell number. Taken together, our data exemplify that a given cell may flexibly respond to type and degree of (micro)environmental changes or cell death stimuli; a cell’s response may shift gradually from the elimination of damaged proteins by autophagy and the recovery to autophagic or apoptotic pathways of cell death, the failure of which eventually may result in necrosis