Examining the Effect of Secondary Packaging on Microbial Penetration into Sterile Medical Device Trays

device trays was examined. Sterile device trays were aseptically filled with growth medium, exposed to microbial challenge, incubated, and inspected for growth. During microbial challenge, all package systems were subjected to a pressure differential that simulated those experienced during distribution. Penetration rates were significantly decreased (P = 0.01) when unlidded trays were packaged in pouches (0/39), compared to those in cartons (37/39). Similarly, the number of colony forming units (CFU) present was greater for unlidded trays packaged in cartons, compared to those in pouches (P = 0.03). To further explore the efficacy of cartons as a barrier to microbial ingress, lidded trays with a single 100 μm breach were packaged in cartons and subjected to the same methodologies; approximately 15% exhibited growth. When compared to unlidded trays, penetration rates (

Comparative reliability and diagnostic performance of conventional 3T magnetic resonance imaging and 1.5T magnetic resonance arthrography for the evaluation of internal derangement of the hip

Objective; To compare the diagnostic accuracy of conventional 3T MRI against 1.5T MR arthrography (MRA) in patients with clinical femoroacetabular impingement (FAI). Methods; Sixty-eight consecutive patients with clinical FAI underwent both 1.5T MRA and 3T MRI. Imaging was prospectively analysed by two musculoskeletal radiologists, blinded to patient outcomes and scored for internal derangement including labral and cartilage abnormality. Interobserver variation was assessed by kappa analysis. Thirty-nine patients subsequently underwent hip arthroscopy and surgical results and radiology findings were analysed. Results; Both readers had higher sensitivities for detecting labral tears with 3T MRI compared to 1.5T MRA (not statistically significant p=0.07). For acetabular cartilage defect both readers had higher statistically significant sensitivities using 3T MRI compared to 1.5T MRA (p=0.02). Both readers had a slightly higher sensitivity for detecting delamination with 1.5T MRA compared to 3T MRI, but these differences were not statistically significant (p=0.66). Interobserver agreement was substantial to perfect agreement for all parameters except the identification of delamination (3T MRI showed moderate agreement and 1.5T MRA substantial agreement). Conclusion; Conventional 3T MRI may be at least equivalent to 1.5T MRA in detecting acetabular labrum and possibly superior to 1.5T MRA in detecting cartilage defects in patients with suspected FAI

Effects of hole size, pressure differential, and secondary packaging on microbial ingress of sterile medical device trays

Nosocomial infections, also referred to as healthcare-associated or hospital-acquired infections (HAIs), are those which hospitalized patients acquire during medical treatment for another condition that were not present or incubating at the time of admission, unless related to a previous admission. These infections are a significant cause of morbidity and mortality that drive up the cost of healthcare in the United States. Despite all of the efforts to prevent nosocomial infections from occurring, they have not been eliminated and are becoming increasingly difficult to treat. It is also difficult determine factors of significance in the causal pathway, such as tracing an infection back to its source. Devices have been cited as sources of infection, both as modes of transmission and reservoirs, but the origin of the pathogens and their transfer to the device are unknown and not widely studied. This raises questions as to whether the devices become contaminated after they are opened, or if their sterile barriers are breached prior to use. The objective of this research was to examine the effects of hole size, pressure differential, and secondary packaging on microbial ingress of sterile medical device trays. The methods involved aseptically filling sealed, sterile device packages with a known volume of an appropriate growth medium, exposing the packages to an aerosolized microbial challenge, incubating the packages, and inspecting for growth. After creating and refining the test techniques, the research explored the impacts of hole size (10 and 100 \u3bcm), pressure differential (0 and -3.78 psi), and secondary packaging (pouches and cartons) on microbial penetration. The specific pressure differential examined simulates an aircraft descending from 8,000 feet or a ground shipment descending from the same elevation. Hole size, pressure differential, and secondary package type all had a statistically significant effect on microbial penetration of the sterile medical device test trays used in the study.Thesis (Ph. D.)--Michigan State University. Packaging, 2011Includes bibliographical reference

Assessing the greenness of environmental advertising claims made by multinational industrial firms

Growing skepticism about green advertisements calls for a thorough investigation of the environmental claims made by firms. This is particularly important in the context of industrial and international markets, where research on the subject is virtually non-existent. By employing legitimacy theory, this article develops several research hypotheses linking various dimensions of environmental claims made in green advertisements (i.e., focal points, evaluation areas, leverage aspects, driving forces) with advertising greenness (i.e., shallow, moderate, deep). It then tests these hypotheses with data obtained from a content analysis of 383 green magazine advertisements by multinational firms producing industrial goods. In accord with legitimacy theory, the results indicate that, the stronger the greenness of an advertisement: (a) the greater the use of focal points relating to a product, processes, image, and facts; (b) the more specific, strong, substantive, and acceptable are the issues raised; (c) the higher the employment of rational, emotional, and moral points to leverage environmental matters; and (d) the sharper the driving forces relating to the planet and its flora, fauna, and human entities. Several important conclusions, managerial implications, and directions for future research are derived from these findings

Branding instead of product innovation: a study on the brand personalities of the UK’s electricity market

This study extends understanding of and demonstrates the importance of corporate branding in the energy sector. We analyse the relationship between branding and consumer switching behaviour among the UK’s Big Six electricity providers. Since privatisation companies have competed against each other, but to the consumer they often appear to have very similar product offerings; firms also face criticism from consumer groups regarding confusing and difficult to compare pricing schemes. This study examines the use of corporate branding to enhance differentiation and specifically examines the influence of brand consistency and brand personality on the retention of customers. Consumers, who find it difficult to compare tariffs, may be influenced by more demonstrable factors like branding. We demonstrate the importance of longitudinal brand consistency, as well as the personality dimension Excitement, which when communicated strongly has the greatest influence on customer retention levels. This work contributes to branding theory, demonstrating that brand personality does differentiate otherwise homogeneous (and low-contact) services. Managerial implications are presented for brands seeking to improve consumer retention

Sports-related lower limb muscle injuries: pattern recognition approach and MRI review

Muscle injuries of the lower limbs are currently the most common sport-related injuries, the impact of which is particularly significant in elite athletes. MRI is the imaging modality of choice in assessing acute muscle injuries and radiologists play a key role in the current scenario of multidisciplinary health care teams involved in the care of elite athletes with muscle injuries. Despite the frequency and clinical relevance of muscle injuries, there is still a lack of uniformity in the description, diagnosis, and classification of lesions. The characteristics of the connective tissues (distribution and thickness) differ among muscles, being of high variability in the lower limb. This variability is of great clinical importance in determining the prognosis of muscle injuries. Recently, three classification systems, the Munich consensus statement, the British Athletics Muscle Injury classification, and the FC Barcelona-Aspetar-Duke classification, have been proposed to assess the severity of muscle injuries. A protocolized approach to the evaluation of MRI findings is essential to accurately assess the severity of acute lesions and to evaluate the progression of reparative changes. Certain MRI findings which are seen during recovery may suggest muscle overload or adaptative changes and appear to be clinically useful for sport physicians and physiotherapists

Supply chain management: a multidisciplinary content analysis of vertical relations between companies, 1997-2006

The aim of this work is to contribute to a better understanding of the research conducted on supply chain management (SCM) at a multidisciplinary level. To this end, a content analysis was performed of the most significant scientific literature about marketing, logistics, management and marketing channels published over the period 1997-2006. As a result, a database of 414 papers from 14 journals was created. Analysis of these works reveals the level of development of the main lines of research into SCM and makes it possible to detect the topics that require greater attention and which may be the object of future studies conducted by researchers and academics. It also allows managerial staff to identify the methodologies and tools that can be used to improve the management of relationships within the supply chain. One of the main conclusions reached in the study is the shortage of studies conducted on the supply chain as a network of enterprises, since most research focuses on a single enterprise or, at the most, on its relationships with its suppliers or direct customers. © 2011 Elsevier Inc.Vallet-Bellmunt, T.; Martínez-Fernández, MT.; Capó-Vicedo, J. (2011). Supply chain management: a multidisciplinary content analysis of vertical relations between companies, 1997-2006. Industrial Marketing Management. 40(8):1347-1367. doi:10.1016/j.indmarman.2011.03.002S1347136740