Targeted Nasal Vaccination Provides Antibody-Independent Protection Against Staphylococcus aureus

Despite showing promise in preclinical models, anti-Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not been studied to formally test whether a cellular-only response can protect against infection. We demonstrate that nasal vaccination with targeted nanoparticles loaded with Staphylococcus aureus antigen protects against acute systemic S. aureus infection in the absence of any antigen-specific antibodies. These findings can help inform future developments in staphylococcal vaccine development and studies into the requirements for protective immunity against S. aureu

The combined effect of hypoxia and mental fatigue on physical and cognitive peformance [Abstract]

The combined effect of hypoxia and mental fatigue on physical and cognitive peformance [Abstract

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Effect of virtual reality and whole-body heating on motion sickness severity: A combined and individual stressors approach

Background: Virtual reality (VR) use is limited by the potential side effects of prolonged exposure to vection, leading to motion sickness. Air temperature (Ta) may exacerbate the severity of such side effects through a synergistic interaction. This study assessed the individual and combined impact of a hot Ta and VR on motion sickness severity. Method: Thirteen healthy volunteers were exposed to a 20 min visual stimulus, across four experimental conditions: N_CS: 22 °C Ta with computer screen; N_VR: 22 °C Ta with VR; H_CS: 35 °C Ta with computer screen; H_VR: 35 °C Ta with VR. Motion sickness was assessed via fast motion sickness scale (FMS) and simulator sickness questionnaire (SSQ). Physiological indices of motion sickness including, sweat rate, rectal temperature, cutaneous vascular conductance (CVC), skin temperature, blood pressure and heart rate were also examined. Results: FMS and SSQ ratings indicate a significant main effect for VR, increasing sickness severity (p < 0.001). A significant main effect of Ta was observed for SSQ, but not FMS ratings (FMS, p = 0.07; SSQ, p < 0.04). Despite trends towards synergism, no interaction (Ta × VR) was observed for FMS (p = 0.2) or SSQ scores (p = 0.07), indicating an additive response. Synergistic trends were also observed for sweat rate and CVC. Conclusion: Synergism between VR and heat on motion sickness remains unclear, possibly as a result of considerable inter-individual variation in the reported subjective responses. Understanding of the questions raised by this study inform safe working guidelines for the use of VR in commercial and occupational settings

Sex-specific trajectories of measures of cardiovascular health during childhood and adolescence:A prospective cohort study

BACKGROUND AND AIMS: Sex differences in measures of cardiovascular health in adults are well documented. However, the sex-specific aetiology of cardiovascular health across childhood and adolescence is poorly understood. METHODS: We examined sex differences in trajectories of 11 measures of cardiovascular health from birth to 18 years, in a contemporary birth cohort study in England (N participants per outcomes: 662-13,985, N repeated measures per outcome: 1,831-112,768). Outcomes were measured over varying time spans from birth or mid-childhood to age 18 and with different numbers of repeated measures per outcome. Analyses were performed using fractional polynomial and linear spline multilevel models. RESULTS: Females had higher mean BMI, height-adjusted fat mass, pulse rate, insulin, triglycerides, and non-high-density lipoprotein cholesterol (HDL-c) and lower mean height-adjusted lean mass from birth or from mid-childhood to age 18. For example, mean non-HDL-c was 0.07 mmol/l (95% confidence interval (CI), 0.04, 0.10) higher in females compared with males at birth. By age 18, this difference persisted and widened to 0.19 mmol/l (95% CI, 0.16, 0.23) higher non-HDL-c in females compared with males. Females had lower levels of glucose from mid-childhood and developed lower systolic blood pressure and higher HDL-c from mid-adolescence onward. For example, females had 0.08 mmol/l (95% CI, 0.05, 0.10) lower mean glucose compared with males at age seven which widened to a difference of 0.22 mmol/l (95% CI, 0.25, 0.19) at age 18. CONCLUSIONS: Sex differences in measures of cardiovascular health are apparent from birth or mid-childhood and change during early life. These differences may have implications for sex-specific disease risk in future adult populations