A clinical study of maternal outcome among pregnant mothers suffering from preeclampsia with thrombocytopenia

Background: The thrombocytopenia in preeclampsia is mild to moderate, but severe thrombocytopenia can occur. Patients with eclampsia were at even greater risk for developing severe thrombocytopenia. And more likely to have HELLP syndrome, which is a subset of preeclampsia. Thrombocytopenia is a key and necessary component of this syndrome. The objective of the present study was to observe a clinical study of maternal outcome among pregnant mothers suffering from preeclampsia with thrombocytopenia.Methods: A Hospital based Study was conducted at Mysore Medical College from January 2018 to December 20180 in the department of Obstetrics and gynecology. A total of 100 cases of Pregnancy from the records / case sheets of pregnant women with pregnancy induced hypertension admitted in the labor ward of the department of obstetrics and gynecology, Mysore Medical College, Mysore, Karnataka, India.Results: Majority of the study subjects in present study were aged between 21-25 years (42%) followed by <20 years (26%). Nearly 55% of the study group were prim parous. In the above table out of 100 cases included in the study, 28 and 40 cases presented with mild and severe pregnancy induced hypertension, 8 cases were diagnosed as eclampsia and 24 cases presented with HELLP syndrome. The association between the mode of delivery and the variants of PIH was found to be statistically not significant. The Association between Mode of delivery and gestation weeks among the eclampsia cases was found to be not significant.Conclusions: Thrombocytopenia in pregnancy induced hypertension carries a risk for both the mother and her fetus. The associated causes like abruption, retain dead fetus, septicemia and disseminated intravascular coagulation aggravates the complication for thrombocytopenia

Aspects of gene regulation after glycan challenge in human THP-1 cells

The primary goal of my research was to better comprehend the various genes involved in fungal infection. Two different approaches were taken to achieve my objective. One is to investigate the genes that are impacted by glycan stimulation, and the other is to investigate the genes that are alternatively spliced in response to glycan stimulation. THP-1 cells were used as the cell model for this research, and glycans such as ß-glucan, scleroglucan, and zymosan were used as fungal ligands. THP-1 cells were stimulated with the glycans ß-glucan and scleroglucan to investigate gene alteration, and zymosan was used in addition to the other two glycans to study alternative splicing. THP-1 cells were activated with different glycans, and RNA-sequencing was performed. The sequencing data showed the participation of genes involved in the activation of both the innate and adaptive immune systems. The TLR signaling pathway, the chemokine signaling pathway, the NLR signaling pathway, the DNA sensing pathway, focal adhesion, and phagocytosis were all impacted by glycan stimulation. LRRC37A3, EFCAB2, WRN, and RAPGEF2 are among the genes that have been variably spliced.Das Hauptziel meiner Arbeit war, die Regulation verschiedener Gene, die an der Pilzerkennung beteiligt sind, besser zu verstehen. Um mein Ziel zu erreichen, habe ich zwei verschiedene Ansätze gewählt. Zum einen wurden die Gene untersucht, die durch die Stimulation mit Glykanen beeinflusst werden, und zum anderen die Gene, die als Reaktion auf die Stimulation mit Glykanen alternativ gespleißt werden. Für diese Fragestellung wurden THP-1 Zellen als Zellmodel verwendet und Glykane wie ß-Glucan, Skleroglucan und Zymosan als Pilzliganden eingesetzt. THP-1 Zellen wurden, um Genveränderungen zu untersuchen, mit den Glykanen ß-Glucan und Skleroglucan stimuliert, Zymosan wurde zusätzlich zu den beiden anderen Glykanen verwendet, um alternatives spleißen zu untersuchen. Nach Stimulation von THP-1 Zellen wurde die RNA aus diesen Zellen extrahiert. Die Sequenzierungsdaten zeigten die Beteiligung von Genen, die an der Aktivierung sowohl des angeborenen als auch des adaptiven Immunsystems beteiligt sind. Der TLR-Signalweg, der Chemokin-Signalweg, der NLR-Signalweg, der DNA-Sensorweg, die fokale Adhäsion und die Phagozytose wurden durch die Glykanstimulation beeinflusst. LRRC37A3, EFCAB2, WRN und RAPGEF2 gehören zu den Genen, die variabel gespleißt wurden

A study on pregnancy outcome in patients with first trimester vaginal bleeding

Background: Vaginal bleeding is a common obstetric problem and a cause of anxiety and worry both to patients and the Obstetrician. The common cause of bleeding in 1st trimester include various types of abortion, ectopic pregnancy and molar pregnancy. This study was conducted to assess the maternal and perinatal outcome in pregnant women who present with first trimester vaginal bleeding.Methods: A Prospective study (Longitudinal study) among pregnant women presenting with First trimester bleeding was conducted for a period from November 2017 to Jan 2019 at Mysore Medical College and Hospital 200 subjects were included into the study by Multiphasic sampling method using a structured questionnaire to collect the data.Results: The study observed that among 200 subjects who were included in the study 123 (61.5%) were non-viable pregnancy and 67 (38.5%) were viable pregnancy. Among 67 viable pregnancy only 30 (47%) had no obstetrical complications, 11 (17.1%) aborted and others had problems of PROM, Preterm labour, Placenta previa, IUGR and IUD.Conclusions: It can be concluded that first trimester bleeding is a predicting factor for obstetric and perinatal complications during pregnancy. Hence it is necessary to increase the knowledge of pregnant women in this regard for closer care. It is also important factor for clinician to be attentive towards first trimester bleeding in providing clinical interventions for the continuation of pregnancy and also reducing the fetal complications in these high-risk pregnancies

Evaluation of perinatal outcome in twin pregnancy at tertiary care centre

Background: The objective of present study was to study the incidence of perinatal mortality and morbidity in twin pregnancy and to analyse the various factors influencing perinatal outcome in these cases.Methods: A total of 117 pregnant women with twin pregnancy were analyzed between the period of September 2010 to February 2012. After applying the inclusion and exclusion criteria these women were analyzed with respect to fetal presentation at the onset of delivery, mode of delivery, APGAR score at 1minute, incidence of perinatal mortality and morbidity rates. Also attempt has been made to define the factors which influence the perinatal mortality and morbidity in twins.Results: In this study it is observed that there is increased incidence of malpresentations 50 (42.7%), increased incidence of congenital malformations (2.6%), increased perinatal mortality (16.7%) and morbidity (21.8%). It is observed that prematurity, i.e. gestational age <37 weeks contributed to 69.9% of total perinatal loss. All perinatal losses except 2 occurred in infants <2 kg. Major factors causing perinatal morbidity were respiratory distress syndrome in (6.4%), transient tachypnoea of newborn (6.4%), septicemia (4.3%), jaundice (3.8%) and anemia (0.9%).  Conclusions: It is observed that in this study perinatal mortality and morbidity rates are increased in the event of a twin pregnancy more so for second twin. Early diagnosis of twin pregnancy, regular antenatal visits, identification and anticipation of complications, planned delivery and good NICU care will help to decrease the perinatal morbidity and mortality

Handwritten Text Recognition Using Convolutional Neural Network

OCR (Optical Character Recognition) is a technology that offers comprehensive alphanumeric recognition of handwritten and printed characters at electronic speed by merely scanning the document. Recently, the understanding of visual data has been termed Intelligent Character Recognition (ICR). Intelligent Character Recognition (ICR) is the OCR module that can convert scans of handwritten or printed characters into ASCII text. ASCII data is the standard format for data encoding in electronic communication. ASCII assigns standard numeric values to letters, numeral, symbols, white-spaces and other characters. In more technical terms, OCR is the process of using an electronic device to transform 2-Dimensional textual information into machine-encoded text. Anything that contains text both machine written or handwritten can be scanned either through a scanner or just simply a picture of the text is enough for the recognition system to distinguish the text. The goal of this papers is to show the results of a Convolutional Neural Network model which has been trained on National Institute of Science and Technology (NIST) dataset containing over a 100,000 images. The network learns from the features extracted from the images and use it to generate the probability of each class to which the picture belongs to. We have achieved an accuracy of 90.54% with a loss of 2.53%.Comment: 6 pages, 15 figure

Printing of Textiles Using Natural Dyes: A Global Sustainable Approach

Globalization has completely changed the fashion industry and its approach toward sustainability. Fast changing trends are majorly focused on synthetic dyes and fabrics. And these products have failed building the bridge between sustainability and environment-friendly designs. Therefore, this chapter is aimed at the approach toward design development and development of sustainable eco-friendly approach for screen printing by using natural dyes on fabrics like silk and cotton. The chapter is based on sustainable design approach which gives much provision for using natural dyes for everyday change in fashion. The chapter also focuses on color fastness properties of the used dyes. These results were evaluated by carrying out color fastness tests for light, wash, rubbing, and perspiration using standard testing methods. Design methodology used in the study also has the potential for skill development programs for entrepreneurs and also contributes to rural development programs by creating sustainable growth

EFFECT OF DIFFERENT SOURCES OF HORIZONTAL TRANSMISSION OF BACTERIAL FLACHERIE ON ET50 FOR SYMPTOM EXPRESSION AND MORTALITY OF PM X CSR2

Flacherie disease of silkworm Bombyx mori L. is also called as Thatte disease (Thatte roga), Benkiroga (Dhadevu roga) and it was first observed from a village in Malavalli taluk of Mandya district during summer months of 1990 (Doreswamy et al., 2001) cause flaccidity in larva, during which they become feeble, lethargic, vomit gut juice and extrude soft faeces with higher water content. Administration of 10 -5 and 10 -7 dilutions of horizontal sources of inoculum to fourth and fifth instar larvae exhibited significant results. It is very clearly indicated that, decreased bacterial dilution exhibited minimum ET 50 value for symptom expression observed for contaminated faecal pellet (9.01. 9.18; 7.01, 7.35 days) for fourth and fifth instar at 10 -5 and 10 -7 , respectively followed by contaminated bed (9.09, 9.38; 7.18, 7.30 days) and (10.17, 10.25; 8.12, 8.30 days). The trend was found same in ET 50 for larval mortality (9.97, 10.12; 8.01, 8.13 days). It was also concluded that, the horizontal transmission was found minimum in contaminated rearing equipment (9.42, 9.72; 11.03, 11.65 days) and (7.51, 7.67; 9.07 9.72 days) used for rearing compared to other sources of horizontal transmission. Which inturn recorded maximum number of days to express the disease in both the instars of PM x CSR2

Getting Started with Positive Energy Districts: Experience until Now from Maia, Reykjavik, Kifissia, Kladno and Lviv

Cities are at the centre of the debate to mitigate climate change. A considerable number of cities have already made commitments to sustainability transitions through the introduction and integration of green strategies. Moreover, in the past few years, Europe has witnessed an increase in the development of smart cities and advancement towards creating more sustainable cities. At the moment, an innovative concept in smart city development involves Positive Energy Districts (PEDs) that further encourage districts and cities to become carbon neutral. This paper looks at the five cities of Maia, Reykjavik, Kifissia, Kladno and Lviv that are a part of an ongoing H2020 project. The purpose of the paper was to understand the status quo of energy transition in these five cities as they embarked on the PEDs journey and identify associated challenges and benefits that PEDs brought to each city. The information was collected through a knowledge gap survey, City Vision 2050 workshop, discussions during the City Forum and individual interviews with city representatives. Cities across Europe and beyond may find themselves in a similar situation, and therefore, this paper also provides brief set of checkpoints to prepare new cities for the PED journey, thus enabling them to transition towards PEDs more efficiently

A Critical Review on use of Gudodaka in Sutika Paricharya

A postnatal period is the period beginning immediately after the separation of placenta and extending up to six weeks, otherwise called as puerperium. Postnatal care is named as Sutika Paricharya in Ayurvedic classics. Garbhini and Sutika Paricharya are very-well described by ancient Ayurvedic scholars. Acharya Kashyapa narrated stage of Prasavaavastha is like a women with her one foot in this Loka and other in Yama Loka . The woman after such a difficulty stage of life needs special care. Classics have described special dietary regimen and life style for this period. Along with DeepanaPachana and Snehadravyas, usage of Gudodaka is advised in Sutikakala. To remove the Sheshadosha in the body Ushna Gudodaka with Panchakola Churna is advised. Guda has Madhura Rasa, Snigdha and Ksharaguna, acts as Raktashodhaka and Vatahara. Jaggery is source of carbohydrate and also has calcium, iron, magnesium, potassium and sodium. So Gudodaka as a part of Sutika diet helps in achieving restoration of health of mother by proper Vatanulomana, Garbhashaya Shodhana, Raktaprasadana Karma

A Comparative Study on Profile Characteristics of Farm Men and Women in Paddy Cultivation: A Study in Shivamogga District

The slogan “RICE is life†is most appropriate for India as this crop plays a vital role in our national food security and is a means of livelihood for millions of rural households. Major Rice growing districts of Karnataka are Bellary, Davangere, Mysore, Mandya, and Shivamogga. The study was conducted in Shivamogga district since Shivamogga district comes under medium productive region of Karnataka state. The study revealed that one third (38.33 %) of farm men had a high level of education whereas, less than half of the respondents (43.34 %) of farm women had a medium level of education. A little more than half (50.00 %) of farm men and farm women belonged to small-sized landholding categories. Concerning extension contact, it is observed that a more significant number (53.33%) of farm men had a medium level of extension agency contact, nearly half (46.57 %) of farm women had a low level of extension contact. Most (43.34 %) of the farm men and around forty percent of farm women had medium-level extension participation. It is evident from the study that farm women stay lower in most of the profile characters than men and there exists a   diversification in socio-economic status, psychological behavior and participative nature of farm men and women due to various gender issues. Hence, this paper throws a light on the comparison of profile characteristics of farm men and farm women who are paddy growers of shivamogga district, where it clearly depicts the profile characters that are low in women than men and that can be taken as a lead to educate the male dominated family to find out the push factors missing for farmwomen and the best way it can be improved. It also helps the policy makers and extension agents to concentrate more on women to improve their socio-economic, psychological and communicational characters in society by suggesting location specific feasible solutions, that further improves the efficiency of farm men and women in paddy cultivation