Community-Based Strategies to Reduce Negative Health Outcomes of Parental Incarceration in Black Children in Cumberland County, NC

Parental incarceration can have negative physical and psychosocial impacts on Black children. To mitigate these negative health outcomes in Cumberland County, North Carolina, a countywide Accountable Care Community (ACC) will be established to target the upstream and downstream factors relating to parental incarceration. The ACC uses a multi-pronged approach, incorporating both a statewide policy with sentencing alternatives to incarceration and a child-centered visitation program at the Cumberland County Jail. Through the policy, primary caretakers will be circumstantially offered programs such as counseling, recovery programs, and educational workshops. These services aim to reduce recidivism and promote positive health outcomes, with an emphasis on food security for dependent children. In tandem, a child-centered visitation program will address the needs of children and their incarcerated parents, with the goals of strengthening parent-child bonds and reducing subsequent negative health outcomes for affected children.Master of Public Healt

Crystal structure of a hypothetical protein from <i>Giardia lamblia</i>. Corrigendum

The name of one of the authors in Beard et al. [(2022), Acta Cryst. F78, 59–65] is corrected.</jats:p

Crystal structure of a hypothetical protein from <i>Giardia lamblia</i>

Giardiasis is the most prevalent diarrheal disease globally and affects humans and animals. It is a significant problem in developing countries, the number one cause of travelers' diarrhea and affects children and immunocompromised individuals, especially HIV-infected individuals. Giardiasis is treated with antibiotics (tinidazole and metronidazole) that are also used for other infections such as trichomoniasis. The ongoing search for new therapeutics for giardiasis includes characterizing the structure and function of proteins from the causative protozoan Giardia lamblia. These proteins include hypothetical proteins that share 30% sequence identity or less with proteins of known structure. Here, the atomic resolution structure of a 15.6 kDa protein was determined by molecular replacement. The structure has the two-layer αβ-sandwich topology observed in the prototypical endoribonucleases L-PSPs (liver perchloric acid-soluble proteins) with conserved allosteric active sites containing small molecules from the crystallization solution. This article is an educational collaboration between Hampton University and the Seattle Structural Genomics Center for Infectious Disease.</jats:p