UK Government pay restraint strategy in the public sector : the experience under cash limits, 1979-83

This thesis focuses on a novel form of UK public sector pay restraint strategy: the indirect control of pay through the limitation of the budgets and expenditure of authorities by means of cash limits and other devices. The 1979-83 period is covered. Four issues are investigated on the basis of archival work, interviews and quantitative data. Since the cash limits pay restraint policy is a relatively new phenomenon, it has received little academic attention. Hence, this investigation makes a contribution to knowledge in respect of all four issues. First, the reasons for Government intervention in pay determination are analysed. The role of the Government's price inflation and public expenditure objectives is highlighted, as are the sources of wage inflation in the economic and political context where finance is determined; in the institutional environment; and in strategic influences. Second, the style of the policy design and policy support is analysed and distinguished from past forms of strategy. Attention is drawn to the greater flexibility of the cash limits policy, and its imposition rather than agreement. Third, the counter-inflationary performance of the strategy is investigated. A statistical and econometric assessment shows the policy had as great an effect as the most successful incomes policies. The explanation is found to lie in the economic and political markets which determined the policy constraints and other financial exigencies; a less inflationary institutional setting; and the acquiescence of negotiators. Fourth, the theoretical and practical implications are drawn out. A theoretical model of pay determination under cash limits is derived from the findings. On a practical note, the contrasting long run experience of incomes policies and cash limits is explained in terms of policy design and support. The likely counter-inflationary effects of variants of the cash limits policy approach and of alternative strategies are assessed

Revisiting the 'Missing Middle' in English Sub-National Governance

In the light of the new Coalition Government’s proposed ‘rescaling’ of sub-national governance away from the regional level, it is an opportune time to re-consider the strength and weaknesses of the city or sub-regional approach to economic development and to search, once more, for the ‘missing middle’ in English Governance. In this context, the article initially assesses the case for city or sub regions as tiers of economic governance, before examining the lessons to be learnt from the experiences of the existing city regions in the North East of England. It argues that while contemporary plans to develop Local Enterprise Partnerships (LEPs) can be usefully considered within the context of the emerging city regional developments under the previous Labour Governments, a number of important challenges remain, particularly in relation to ensuring accountable structures of governance, a range of appropriate functions, adequate funding, and comprehensive coverage across a variety of sub-regional contexts. While the proposals of the new Government create the necessary ‘space’ to develop sub-regional bodies and offer genuine opportunities for both city and county LEPs, the scale of the sub-regional challenge should not be underestimated, particularly given the context of economic recession and major reductions in the public sector

A Method for Assessing Blackbird Damage to Ripening Rice

A method for measuring and mapping the location of blackbird (Icterinae) damage to ripening rice over time was developed and employed in 7 commercial rice fields ranging from 20.6 to 47.4 ha in Matagorda County, Texas, during the 1985 and 1986 growing seasons. Ten evenly-spaced transects were established perpendicular to the longest side of the field and each transect was sampled at pre-determined distances. Transects were subdivided into edge ( \u3c = 60 m from field border) and middle ( \u3e 60 m from the field border) strata. The measured percent damage was compared to visual estimates for 3 samplings to assess the accuracy and precision of the latter. Measuring the percent damage to individual panicles appears to be valid, but damage may be underestimated. This sampling method may be useful for assessing the efficacy of current and proposed damage control techniques. Visual estimates were too high at low ( \u3c 5%) damage levels and too low at higher ( \u3e 5%) levels compared to measured damage

A METHOD FOR ASSESSING BLACKBIRD DAMAGE TO RIPENING RICE

A method for measuring and mapping the location of blackbird (Icterinae) damage to ripening rice over time was developed and employed in 7 commercial rice fields ranging from 20.6 to 47.4 ha in Matagorda County, Texas, during the 1985 and 1986 growing seasons. Ten evenly-spaced transects were established perpendicular to the longest side of the field and each transect was sampled at pre-determined distances. Transects were subdivided into edge (\u3c= 60 m from field border) and middle (\u3e 60 m from the field border) strata. The measured percent damage was compared to visual estimates for 3 samplings to assess the accuracy and precision of the latter. Measuring the percent damage to individual panicles appears to be valid, but damage may be underestimated. This sampling method may be useful for assessing the efficacy of current and proposed damage control techniques. Visual estimates were too high at low (\u3c 5%) damage levels and too low at higher (\u3e 5%) levels compared to measured damage

The medical student

The Medical Student was published from 1888-1921 by the students of Boston University School of Medicine

Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes

Antigen-specific age-related memory CD8 T cells induce and track Alzheimer’s-like neurodegeneration

Cerebral (Aβ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer’s disease (AD), yet are insufficient to confer complete AD-like neurodegeneration experimentally. Factors acting upstream of Aβ/pTau in AD remain unknown, but their identification could enable earlier diagnosis and more effective treatments. T cell abnormalities are emerging AD hallmarks, and CD8 T cells were recently found to mediate neurodegeneration downstream of tangle deposition in hereditary neurodegeneration models. The precise impact of T cells downstream of Aβ/pTau, however, appears to vary depending on the animal model. Our prior work suggested that antigen-specific memory CD8 T (“hiT”) cells act upstream of Aβ/pTau after brain injury. Here, we examine whether hiT cells influence sporadic AD-like pathophysiology upstream of Aβ/pTau. Examining neuropathology, gene expression, and behavior in our hiT mouse model we show that CD8 T cells induce plaque and tangle-like deposition, modulate AD-related genes, and ultimately result in progressive neurodegeneration with both gross and fine features of sporadic human AD. T cells required Perforin to initiate this pathophysiology, and IFNγ for most gene expression changes and progression to more widespread neurodegenerative disease. Analogous antigen-specific memory CD8 T cells were significantly elevated in the brains of human AD patients, and their loss from blood corresponded to sporadic AD and related cognitive decline better than plasma pTau-217, a promising AD biomarker candidate. We identify an age-related factor acting upstream of Aβ/pTau to initiate AD-like pathophysiology, the mechanisms promoting its pathogenicity, and its relevance to human sporadic AD.</p

A Developmental Perspective on Community Service in Adolescence

A substantial number of U.S. adolescents currently participate in community service and there is increased national interest in service programs. This article assesses the assumption of developmental benefits to service participants by critically reviewing 44 empirical studies. It offers a theoretical framework for understanding the findings by connecting them to identity development and delineating three pertinent concepts: agency, social relatedness, and moral-political awareness. These concepts are applied to studies that investigate: ( 1) the characteristics and motivations of participants, ( 2) the effects of service, and ( 3) the process of service. The findings support the conclusion that service activities which provide opportunities for intense experiences and social interactions are often associated with prosocial development. The findings also point to the need for more studies focused on particular service programs and on relationships between service providers and those served