Wind Variability in BZ Camelopardalis

(Shortened) Sequences of spectra of the nova-like cataclysmic variable (CV) BZ Cam were acquired on 9 nights in 2005-2006 in order to study the time development of episodes of wind activity known to occur frequently in this star. We confirm past results that the P-Cygni absorption components of the lines mostly evolve from a higher expansion velocity to lower velocity as an episode progresses. We also commonly find blueshifted emission components in the Halpha line profile, whose velocities and durations strongly suggest that they are also due to the wind. We suggest that the progression from larger to smaller expansion velocities is due the higher velocity portions of a wind concentration moving beyond the edge of the continuum light of the disk first, leaving a net redward shift of the remaining absorption profile. We also derive a new orbital ephemeris for BZ Cam, using the radial velocity of the core of the HeI 5876AA line, finding P = 0.15353(4). Using this period the wind episodes in BZ Cam are found to be concentrated near inferior conjuction of the emission line source. This result confirms that the winds in nova-like CVs are often phase dependent, in spite of the puzzling implication that such winds lack axisymmetry. We argue that the radiation-driven wind in BZ Cam receives an initial boost by acting on gas that has been lifted above the disk by the interaction of the accretion stream with the disk, thereby imposing flickering time scales onto the wind events, as well as leading to an orbital modulation of the wind due to the non-axisymmetric nature of the stream/disk interaction.Comment: The Astronomical Journal, in pres

Leisure geographies of young people: cross-cultural perspectives

Peer reviewe

Inhibition of the Redox Function of APE1/Ref-1 in Myeloid Leukemia Cell Lines Results in a Hypersensitive Response to Retinoic Acid-induced Differentiation and Apoptosis

Objective The standard of care for promyelocytic leukemia includes use of the differentiating agent all-trans retinoic acid (RA) and chemotherapy. RA induces cell differentiation through retinoic acid receptor (RAR) transcription factors. Because redox mechanisms influence how readily transcription factors bind to DNA response elements (RARE), the impact of small molecule (E3330) inhibition of the redox regulatory protein, apurinic-apyrimidinic endonuclease/redox effector factor (APE1/Ref-1) on RAR DNA binding and function in RA-induced myeloid leukemia cell differentiation and apoptosis was investigated. Materials and Methods The redox function of APE1 was studied using the small molecule inhibitor E3330 in HL-60 and PLB acute myeloid leukemia cells. Electrophoretic mobility shift assays were employed to determine effect of inhibitor on APE1/Ref-1 redox signaling function. Trypan blue assays, Annexin-V/propidium iodide and CD11b staining, and real-time polymerase chain reaction analyses were employed to determine survival, apoptosis, and differentiation status of cells in culture. Results RARα binds to its RARE in a redox-dependent manner mediated by APE1/Ref-1 redox regulation. Redox-dependent RAR-RARE binding is blocked by E3330, a small molecule redox inhibitor of APE1/Ref-1. Combination treatment of RA + E3330 results in a profound hypersensitivity of myeloid leukemia cells to RA-induced differentiation and apoptosis. Additionally, redox inhibition by E3330 results in enhanced RAR target gene, BLR-1, expression in myeloid leukemia cells. Conclusions The redox function of APE1/Ref-1 regulates RAR binding to its DNA RAREs influencing the response of myeloid leukemia cells to RA-induced differentiation. Targeting of APE1/Ref-1 redox function may allow manipulation of the retinoid response with therapeutic implications

Image and information management system

A system and methods through which pictorial views of an object's configuration, arranged in a hierarchical fashion, are navigated by a person to establish a visual context within the configuration. The visual context is automatically translated by the system into a set of search parameters driving retrieval of structured data and content (images, documents, multimedia, etc.) associated with the specific context. The system places ''hot spots'', or actionable regions, on various portions of the pictorials representing the object. When a user interacts with an actionable region, a more detailed pictorial from the hierarchy is presented representing that portion of the object, along with real-time feedback in the form of a popup pane containing information about that region, and counts-by-type reflecting the number of items that are available within the system associated with the specific context and search filters established at that point in time

Image and information management system

A system and methods through which pictorial views of an object's configuration, arranged in a hierarchical fashion, are navigated by a person to establish a visual context within the configuration. The visual context is automatically translated by the system into a set of search parameters driving retrieval of structured data and content (images, documents, multimedia, etc.) associated with the specific context. The system places hot spots, or actionable regions, on various portions of the pictorials representing the object. When a user interacts with an actionable region, a more detailed pictorial from the hierarchy is presented representing that portion of the object, along with real-time feedback in the form of a popup pane containing information about that region, and counts-by-type reflecting the number of items that are available within the system associated with the specific context and search filters established at that point in time

Shape-based peak identification for ChIP-Seq

We present a new algorithm for the identification of bound regions from ChIP-seq experiments. Our method for identifying statistically significant peaks from read coverage is inspired by the notion of persistence in topological data analysis and provides a non-parametric approach that is robust to noise in experiments. Specifically, our method reduces the peak calling problem to the study of tree-based statistics derived from the data. We demonstrate the accuracy of our method on existing datasets, and we show that it can discover previously missed regions and can more clearly discriminate between multiple binding events. The software T-PIC (Tree shape Peak Identification for ChIP-Seq) is available at http://math.berkeley.edu/~vhower/tpic.htmlComment: 12 pages, 6 figure

Conceiving time?: women who do or do not conceive

This article explores the importance of time for an understanding of women's experiences of reproductive identity. In order to do this we draw on data from two separate qualitative research projects. The first project is concerned with the experiences of conception, pregnancy, childbirth and early motherhood in primagravidae, whilst the second focuses on the experiences of individuals (especially women) who defined themselves (at the time of the fieldwork, or some time previously) as 'involuntarily childless' and/or 'infertile'. These two areas are usually treated as separate; however this article explores similarities between them in terms of time and medicalisation. Our central concern then is with exploring the similarities of experience for women who do or do not conceive

Evolution of the sugar receptors in insects

<p>Abstract</p> <p>Background</p> <p>Perception of sugars is an invaluable ability for insects which often derive quickly accessible energy from these molecules. A distinctive subfamily of eight proteins within the gustatory receptor (Gr) family has been identified as sugar receptors (SRs) in <it>Drosophila melanogaster </it>(Gr5a, Gr61a, and Gr64a-f). We examined the evolution of these SRs within the 12 available Drosophila genome sequences, as well as three mosquito, two moth, and beetle, bee, and wasp genome sequences.</p> <p>Results</p> <p>While most Drosophila species retain all eight genes, we find that the three Drosophila subgenus species have lost Gr64d, while <it>D. grimshawi </it>and the <it>D. pseudoobscura/persimilis </it>sibling species have also lost Gr5a function. The entire Gr64 gene complex was also duplicated in the <it>D. grimshawi </it>lineage, but only one potentially functional copy of each gene has been retained. The numbers of SRs range from two in the hymenopterans <it>Apis mellifera </it>and <it>Nasonia vitripennis </it>to 16 in the beetle <it>Tribolium castaneum</it>. An unusual aspect is the evolution of a novel exon from intronic sequence in an expanded set of four SRs in <it>Bombyx mori </it>(BmGr5-8), which appears to be the first example of such exonization in insects. Twelve intron gains and 63 losses are inferred within the SR family.</p> <p>Conclusion</p> <p>Examination of the SRs in these fly, mosquito, moth, beetle, and hymenopteran genome sequences reveals that they appear to have originated independently from single ancestral genes within the dipteran and coleopteran lineages, and two genes in the lepidopteran and hymenopteran lineages. The origin of the insect SRs will eventually be illuminated by additional basal insect and arthropod genome sequences.</p

The Herschel Virgo cluster survey: V. Star-forming dwarf galaxies - dust in metal-poor environments

We present the dust properties of a small sample of Virgo cluster dwarf galaxies drawn from the science demonstration phase data set of the Herschel Virgo Cluster Survey. These galaxies have low metallicities (7.8 < 12 + log(O/H) < 8.3) and star-formation rates < 10^{-1} M_{sun}/yr. We measure the spectral energy distribution (SED) from 100 to 500 um and derive dust temperatures and dust masses. The SEDs are fitted by a cool component of temperature T < 20 K, implying dust masses around 10^{5} M_{sun} and dust-to-gas ratios D within the range 10^{-3}-10^{-2}. The completion of the full survey will yield a larger set of galaxies, which will provide more stringent constraints on the dust content of star-forming dwarf galaxies.Comment: Letter accepted for publication in A&A (Herschel special issue