Autworks: a Cross-Disease Network Biology Application for Autism and Related Disorders

Background: The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results. Description: We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis. Conclusions: Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders

Migratory Typing: Ten Years Later

In this day and age, many developers work on large, untyped code repositories. Even if they are the creators of the code, they notice that they have to figure out the equivalent of method signatures every time they work on old code. This step is time consuming and error prone. Ten years ago, the two lead authors outlined a linguistic solution to this problem. Specifically they proposed the creation of typed twins for untyped programming languages so that developers could migrate scripts from the untyped world to a typed one in an incremental manner. Their programmatic paper also spelled out three guiding design principles concerning the acceptance of grown idioms, the soundness of mixed-typed programs, and the units of migration. This paper revisits this idea of a migratory type system as implemented for Racket. It explains how the design principles have been used to produce the Typed Racket twin and presents an assessment of the project\u27s status, highlighting successes and failures

Accounting Accreditation: Value Added Or Waste Of Resources?

In a forthcoming paper Everard, Edmonds, and St. Pierre (2014) question whether the AACSB has achieved its mission of recognizing excellence in business education and whether it has shown continuous improvement in its efforts since the change to a mission driven focus. In this paper, the authors expand on this topic and address the value of accounting accreditation from the perspective of the market it serves, whether accounting accreditation has diminished in value because of the quality of the programs being accredited, and whether accounting accreditation is an idea that has run its course. We conclude that since the move to a mission driven focus, the AACSB has diminished its brand, has failed in its ability todifferentiate quality accounting programs in the higher education market, and has not met its objective of continuous improvement for the organization itself. Unless changes are made in the organization, itsvalue in the higher education marketplace will diminish over time and the brand could become irrelevant

Measuring the Success of Female Faculty in the IS Research Arena: An Empirical Investigation

The gender disparity in the US IT workforce is well documented (Brandel, 2014). This research-in-progress looks at (1) whether a concomitant gender gap exists in MIS university faculty members and (2) whether women and men university faculty members are equally successful in the profession, as measured by their publishing activity in the leading MIS journals. In order to investigate these issues, we collect data on (1) female representation in the IS discipline and (2) female representation in the leading IS journals. We are not only interested in how many women are in the MIS academic field, but how successful they are from a publication perspective. Just as having a diverse workforce and female-friendly policies is touted as good business for industry, having a diverse workforce is good for academia. Having more women faculty members increases the attractiveness of the profession for other women, especially if they are deemed successful

Characteristics of transposable element exonization within human and mouse

Insertion of transposed elements within mammalian genes is thought to be an important contributor to mammalian evolution and speciation. Insertion of transposed elements into introns can lead to their activation as alternatively spliced cassette exons, an event called exonization. Elucidation of the evolutionary constraints that have shaped fixation of transposed elements within human and mouse protein coding genes and subsequent exonization is important for understanding of how the exonization process has affected transcriptome and proteome complexities. Here we show that exonization of transposed elements is biased towards the beginning of the coding sequence in both human and mouse genes. Analysis of single nucleotide polymorphisms (SNPs) revealed that exonization of transposed elements can be population-specific, implying that exonizations may enhance divergence and lead to speciation. SNP density analysis revealed differences between Alu and other transposed elements. Finally, we identified cases of primate-specific Alu elements that depend on RNA editing for their exonization. These results shed light on TE fixation and the exonization process within human and mouse genes.Comment: 11 pages, 4 figure

Contributors to the High-impact IS Journals (1977-2014): An Aid for Setting Research Standards

Interest in the rankings of contributors to academic literature is evidenced by the numerous publications across most business and economic disciplines. This study presents the most prolific authors 1) over the entire history of the 11 high-impact IS journals and 2) over the ten most recent years for each of the journals. We include the number of authors who have published in the journals but who may not be considered prolific based on our classification; this data is important and especially critical for IS departments that set research standards. Identifying and ranking authors in the IS discipline is interesting for several reasons. While some may be curious to see how they perform compared to these researchers, a more beneficial application of the findings in this paper pertains to establishing realistic promotion and tenure standards. Although 11,204 authors published in the 11 high-impact journals, 7,734 (69%) of those authors published only once in these journals in the 1977-2014 period. This fact is essential for any IS department that sets promotion and tenure guidelines. Using our findings will help colleges and IS departments establish reasonable and attainable promotion and tenure standards based on the actual performance of others in the discipline

A randomised control crossover trial of a theory based intervention to improve sun-safe and healthy behaviours in construction workers:Study protocol

Abstract Background Exposure to sunlight can have both positive and negative health impacts. Excessive exposure to ultra-violet (UV) radiation from the sun can cause skin cancer, however insufficient exposure to sunlight has a detrimental effect on production of Vitamin D. In the construction industry there are onsite proactive behaviours for safety, but sun-safety remains a low priority. There is limited research on understanding the barriers to adopting sun-safe behaviours and the association this may have with Vitamin D production. This paper reports a protocol for an intervention study, using text messaging in combination with a supportive smartphone App. The intervention aims to both reduce UV exposure during months with higher UV levels and promote appropriate dietary changes to boost Vitamin D levels during months with low UV levels. Method/design Approximately 60 construction workers will be recruited across the United Kingdom. A randomised control crossover trial (RCCT) will be used to test the intervention, with randomisation at site level – i.e. participants will receive both the control (no text messages or supportive App support) and intervention (daily text messages and supportive App). Using the Theory of Planned Behaviour (TPB) the intervention focuses on supporting sun-safety and healthy dietary decisions in relation to Vitamin D intake. The intervention emphasises cultivating the perception of normative support in the workplace, increasing awareness of control and self-efficacy in taking sun-protective behaviours, making healthier eating choices to boost Vitamin D, and tackling stigmas attached to image and group norms. Each study epoch will last 21 days with intervention text messages delivered on workdays only. The supportive App will provide supplementary information about sun protective behaviours and healthy dietary choices. The primary outcome measure is 25-hydroxy-Vitamin D [25(OH)D] level (obtained using blood spot sampling), which will be taken pre and post control and intervention periods. Secondary outcome measures are two-fold, (1) using the TPB to detect changes in behaviour, and (2) quantifying UV exposure during the UK peak radiation season (April–September) using body-mounted UV sensors. Discussion This study will provide important information about the effectiveness of a technology-based intervention to promote sun-safety and healthy behaviours in outdoor construction workers. Trial registration ISRCTN15888934 retrospectively registered 15.01.2018

The Galleria mellonella Hologenome Supports Microbiota-Independent Metabolism of Long-Chain Hydrocarbon Beeswax

The greater wax moth, Galleria mellonella, degrades wax and plastic molecules. Despite much interest, the genetic basis of these hallmark traits remains poorly understood. Herein, we assembled high-quality genome and transcriptome data from G. mellonella to investigate long-chain hydrocarbon wax metabolism strategies. Specific carboxylesterase and lipase and fatty-acid-metabolism-related enzymes in the G. mellonella genome are transcriptionally regulated during feeding on beeswax. Strikingly, G. mellonella lacking intestinal microbiota successfully decomposes long-chain fatty acids following wax metabolism, although the intestinal microbiome performs a supplementary role in short-chain fatty acid degradation. Notably, final wax derivatives were detected by gas chromatography even in the absence of gut microbiota. Our findings provide insight into wax moth adaptation and may assist in the development of unique wax-degradation strategies with a similar metabolic approach for a plastic molecule polyethylene biodegradation using organisms without intestinal microbiota. The evolutionarily expanded long-chain fatty acid degradation gene products of Galleria mellonella decompose long-chain hydrocarbons independently of intestinal microorganisms. Kong et al. show that beeswax and degradation products are detected equally in larvae in the presence or absence of intestinal microbes

Clothing sustainability and upcycling in Ghana

The aim of this paper is to assess opportunities for the upcycling of waste clothing through design workshops held in Accra, Ghana. An upcycling approach to clothing longevity examines how garments can be re-designed and resold in a new form. Significant amounts of surplus and second-hand clothing from the developed world and large producer nations, for example China, are distributed to Africa and sold in local markets at affordable prices. The research was conducted into upcycling waste clothing from the market by five groups of fashion design students at Accra Technical University (ATU). A participatory research design was applied to the project and the initial briefing to design groups confirmed the concept of upcycling and the design parameters. Each group defined a design theme, made a selection of clothes and accessories in the Accra market and returned to the university to conceptualise and re-create clothes and accessories. The project culminated in presentations of finished garments modelled by the students. It addressed the disposal stage of the circular economy model of clothing sustainability by providing new knowledge of how waste clothing, readily available in a developing country’s market can be sourced and creatively re-designed into new garments and accessories

How do risk attitudes affect measured confidence?

We examine the relationship between confidence in own absolute performance and risk attitudes using two confidence elicitation procedures: self-reported (non-incentivised) confidence and an incentivised procedure that elicits the certainty equivalent of a bet based on performance. The former procedure reproduces the “hard-easy effect” (underconfidence in easy tasks and overconfidence in hard tasks) found in a large number of studies using non-incentivised self-reports. The latter procedure produces general underconfidence, which is significantly reduced, but not eliminated when we filter out the effects of risk attitudes. Finally, we find that self-reported confidence correlates significantly with features of individual risk attitudes including parameters of individual probability weighting