Interval brain imaging for adults with cerebral glioma

© 2018 The Cochrane Collaboration. This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine whether interval brain imaging (performing brain imaging at regular intervals) compared with brain imaging upon clinical indication (performing brain imaging upon the development of new or worsening symptoms) improves outcomes associated with cerebral glioma. To appraise critically and summarise current evidence on the costs and cost-effectiveness of interval brain imaging compared with symptomatic imaging

Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders

Prova tipográfica (uncorrected proof)Neurodevelopmental disorders such as epilepsy, intellectual disability (ID), and autism spectrum disorders (ASDs) occur in over 2 % of the population, as the result of genetic mutations, environmental factors, or combination of both. In the last years, use of large-scale genomic techniques allowed important advances in the identification of genes/loci associated with these disorders. Nevertheless, following association of novel genes with a given disease, interpretation of findings is often difficult due to lack of information on gene function and effect of a given mutation in the corresponding protein. This brings the need to validate genetic associations from a functional perspective in model systems in a relatively fast but effective manner. In this context, the small nematode, Caenorhabditis elegans, presents a good compromise between the simplicity of cell models and the complexity of rodent nervous systems. In this article, we review the features that make C. elegans a good model for the study of neurodevelopmental diseases. We discuss its nervous system architecture and function as well as the molecular basis of behaviors that seem important in the context of different neurodevelopmental disorders. We review methodologies used to assess memory, learning, and social behavior as well as susceptibility to seizures in this organism. We will also discuss technological progresses applied in C. elegans neurobiology research, such as use of microfluidics and optogenetic tools. Finally, we will present some interesting examples of the functional analysis of genes associated with human neurodevelopmental disorders and how we can move from genes to therapies using this simple model organism.The authors would like to acknowledge Fundação para a Ciência e Tecnologia (FCT) (PTDC/SAU-GMG/112577/2009). AJR and CB are recipients of FCT fellowships: SFRH/BPD/33611/2009 and SFRH/BPD/74452/2010, respectively

Bone-anchored hearing aid modified with directional microphone: do patients benefit?

Trabajo presentado en: II Congreso Español Herpetología; Programa y Resúmenes.[ES]Los yacimientos fosilíferos paleógenos situados al N del río Duero se caracterizan por una fauna reptiliana en la que se observan diferencias claras con respecto a las de la misma edad ubicadas al S de dicho río.[EN]The Paleogene fossil deposits located to the N of the Douro River are characterized by a reptilian fauna in which clear differences were observed with respect to the same age located at the S of that river.Españo