99 research outputs found

    Hume's Perceptual Relationism

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    My topic in this paper will be Hume’s claim that we have no idea of a vacuum. I offer a novel interpretation of Hume’s account of our ideas of extension that makes it clear why those ideas cannot include any ideas of vacuums, and I distinguish my interpretation from prominent readings offered by other Hume scholars. An upshot of Hume’s account, I will argue, is his commitment to a remarkable and distinctly Humean view I call “perceptual relationism.” Perceptual relationism is a fundamental characteristic of Hume’s “universe of the imagination,” and a manifestation of just how “loose and separate” the constituents of that inner universe are. Once we understand perceptual relationism and its entailments, we are in a better position to understand the rest of Hume’s sometimes puzzling remarks on space and the vacuum

    Gothic Girlhood and Resistance: Confronting Ireland’s Neoliberal Containment Culture in Tana French’s The Secret Place

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    The Secret Place (2014) exposes a persistent Western cultural impulse to contain the emotions of teenage girls when they demonstrate control over their lives. In the Irish context, the dismissal of teenage girls is resonant of a containment culture in which controlling women’s bodies and minds has been essential to upholding heteropatriarchal ideals. Resistance to the novel’s unresolved supernatural elements by readers and critics and the lack of sustained academic scholarship also point to an unsettling complacency with the neoliberal impulse to contain female emotion and lived experience in post-Celtic Tiger Ireland

    Hume against the Geometers

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    In the Treatise of Human Nature, David Hume mounts a spirited assault on the doctrine of the infinite divisibility of extension, and he defends in its place the contrary claim that extension is everywhere only finitely divisible. Despite this major departure from the more conventional conceptions of space embodied in traditional geometry, Hume does not endorse any radical reform of geometry. Instead Hume espouses a more conservative approach, claiming that geometry fails only “in this single point” – in its purported proofs of infinite divisibility – while “all of its other arguments” remain intact. In this paper, after laying out the prima facie case for Hume’s radical challenge to traditional geometry, I consider five strategies for blocking the arguments for infinite divisibility while conserving most of geometry. I show that each of these interpretive strategies suffers from serious substantive problems, and so none of them delivers an interpretation of Hume’s account that provides him with a way of blocking the geometric arguments for infinite divisibility while sustaining his geometric conservatism

    Bacillus cereus efflux protein BC3310 – a multidrug transporter of the unknown major facilitator family, UMF-2

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    Phylogenetic classification divides the major facilitator superfamily (MFS) into 82 families, including 25 families that are comprised of transporters with no characterized functions. This study describes functional data for BC3310 from Bacillus cereus ATCC 14579, a member of the “unknown major facilitator family-2” (UMF-2). BC3310 was shown to be a multidrug efflux pump conferring resistance to ethidium bromide, SDS and silver nitrate when heterologously expressed in Escherichia coli DH5α acrAB. A conserved aspartate residue (D105) in putative transmembrane helix 4 was identified, which was essential for the energy dependent ethidium bromide efflux by BC3310. Transport proteins of the MFS comprise specific sequence motifs. Sequence analysis of UMF- 2 proteins revealed that they carry a variant of the MFS motif A, which may be used as a marker to distinguish easily between this family and other MFS proteins. Genes orthologous to bc3310 are highly conserved within the B. cereus group of organisms and thus belong to the core genome, suggesting an important conserved functional role in the normal physiology of these bacteria

    Extreme wave loading on a semi-submerged heaving body

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