Towards developing a customer relationship management (CRM) strategy for supporting pre-implementation activities in business

Effectively preparing and planning for Customer Relationship Management (CRM) strategy is critical to CRM implementation success. A lack of a common and systematic way to implement CRM means that focus must be placed on the pre-implementation stage to ensure chance of success. Although existing CRM implementation approaches evidence the need to concentrate mostly on the pre-implementation stage, they fail to address some key issues, which raises the need for a generic framework that address CRM strategy analysis. This paper proposes a framework to support effective CRM pre-implementation strategy development

LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2

Additional file 4: Figure S3. Representative images of colony formation of Mino cells. a The number of colonies in MALAT1 knockdown Mino cells were significantly reduced. b Photographs of colonies in colony formation assay. The size of individual colony was significantly reduced in MALAT1 knockdown Mino cells

Safety and efficacy of endoscopic submucosal dissection for rectal neoplasia: a multicenter North American experience.

Background and aims  Rectal lesions traditionally represent the first lesions approached during endoscopic submucosal dissection (ESD) training in the West. We evaluated the safety and efficacy of rectal ESD in North America. Methods  This is a multicenter retrospective analysis of rectal ESD between January 2010 and September 2018 in 15 centers. End points included: rates of en bloc resection, R0 resection, adverse events, comparison of pre- and post-ESD histology, and factors associated with failed resection. Results  In total, 171 patients (median age 63 years; 56 % men) underwent rectal ESD (median size 43 mm). En bloc resection was achieved in 141 cases (82.5 %; 95 %CI 76.8-88.2), including 24 of 27 (88.9 %) with prior failed endoscopic mucosal resection (EMR). R0 resection rate was 74.9 % (95 %CI 68.4-81.4). Post-ESD bleeding and perforation occurred in 4 (2.3 %) and 7 (4.1 %), respectively. Covert submucosal invasive cancer (SMIC) was identified in 8.6 % of post-ESD specimens. There was one case (1/120; 0.8 %) of recurrence at a median follow-up of 31 weeks; IQR: 19-76 weeks). Older age and higher body mass index (BMI) were predictors of failed R0 resection, whereas submucosal fibrosis was associated with a higher likelihood of both failed en bloc and R0 resection. Conclusion  Rectal ESD in North America is safe and is associated with high en bloc and R0 resection rates. The presence of submucosal fibrosis was the main predictor of failed en bloc and R0 resection. ESD can be considered for select rectal lesions, and serves not only to establish a definitive tissue diagnosis but also to provide curative resection for lesions with covert advanced disease

First case of sexual cannibalism in \u3ci\u3eLeiurus abdullahbayrami\u3c/i\u3e Yağmur, Koç & Kunt, 2009 (Scorpiones: Buthidae) from Lebanon

This study presents the first report of sexual cannibalism in the medically significant scorpion Leiurus abdullahbayrami Yağmur, Koç & Kunt, 2009, that was recorded during a herpetological field trip to the semi-desert area in northern Lebanon. It broadens the understanding of sexual cannibalism in scorpions and adds a new prey item to the dietary spectrum of the scorpion

Primary Care Provider Insight Toward Oral Cancer Screening in Jeddah, Saudi Arabia 2022

Background: Oral cancer is a growing public health threat affecting annually more than two million of the global population and the rates are increasing. Also, it is usually diagnosed in advanced stages and carries high morbidity and mortality rates. Proper knowledge of primary healthcare physicians, who usually are in the first line of facing the problem, is the most important factor for ensuring early diagnosis and management. Objectives: To assess the level of oral cancer knowledge, opinions, attitudes, and screening practices among primary care physicians working at primary care centers. Material and methods: An analytical cross-sectional study design was conducted in Jeddah city, Saudi Arabia among currently working Ministry of Health (MOH) primary healthcare (PHC) physicians throughout the study period; 2023-2024. A self-administered validated questionnaire was utilized for data collection. It consists of four main parts: Socio-demographic characteristics of physicians, knowledge, attitude, and practice related to oral cancer questions and statements. Results: The study included 199 physicians. Almost two-thirds (65.8%) were females. Approximately one-fifth (22.1%) were aged between 25 and 30 years and 17.1% were aged over 50 years. History of previous attending training courses in oral cancer screening was reported by 6.5 of the participants. Overall, the total knowledge score ranged between 2 and 14; out of a possible maximum of 15 while the attitude score ranged between 1 and 7; out of a possible maximum of 7, and practice score ranged between 0 and 3; out of a possible maximum of 3. The highest knowledge score was observed among physicians aged over 50 years (mean rank=126.59) whereas the lowest score was observed among those aged between 25 and 30 years (mean rank=81.65), p=0.036. Non-Saudi physicians were more knowledgeable about oral cancer than Saudis (mean ranks were 123.90 vs. 95.08), p=0.007. The highest knowledge score was observed among physicians whose experience in primary healthcare exceeded 10 years (mean rank=110.15) whereas the lowest score was observed among those whose experience was one year or less (mean rank=83.02), p=0.041. Physicians who reported previously attending training courses in oral cancer screening were more knowledgeable about oral cancer and its screening than their peers (mean ranks were 142.77 vs. 97.01), p=0.005. Conclusion: Knowledge of primary care physicians about the risk factors of oral cancer was quite accepted and also, and their attitude toward further training was encouraging. However, few of them had training courses in oral cancer screening and their overall practice regarding oral cancer was not appropriate in many aspects

Comparison of EUS-guided tissue acquisition using two different 19-gauge core biopsy needles: a multicenter, prospective, randomized, and blinded study

BACKGROUND AND STUDY AIMS: The optimal core biopsy needle for endoscopic ultrasound (EUS) is unknown. The principle aim of this study is to compare outcomes of EUS-fine-needle biopsy (EUS-FNB) with a new 19-gauge EUS histology needle (ProCore, Cook Medical Inc., Winston-Salem, North Carolina, United States) to a conventional 19-gauge Tru-Cut biopsy (EUS-TCB) needle (19G, Quick-Core, Cook Medical Inc.). PATIENTS AND METHODS: Patients referred for EUS who require possible histologic biopsy were prospectively randomized to EUS-FNB or EUS-TCB. With the initial needle, ≤ 3 biopsies were obtained until either technical failure or an adequate core was obtained. Patients with suspected inadequate biopsies were crossed over to the other needle and similarly ≤ 3 passes were obtained until adequate cores or technical failure occurred. Technical success, diagnostic histology, accuracy and complication rates were evaluated. RESULTS: Eighty-five patients (mean 58 years; 43 male) were randomized to FNB (n = 44) and TCB (n = 41) with seven patients excluded. Procedure indication, biopsy site, mass size, number of passes, puncture site, overall technical success and adverse events were similar between the two groups. FNB specimens had a higher prevalence of diagnostic histology (85 % vs. 57 %; P = 0.006), accuracy (88 % vs. 62 %; P = 0.02), mean total length (19.4 vs. 4.3 mm; P = 0.001), mean complete portal triads from liver biopsies (10.4 vs. 1.3; P = 0.0004) and required fewer crossover biopsies compared to those of TCB (2 % vs. 65 %; P = 0.0001). Overall technical success and complication rates were comparable. CONCLUSION: EUS-FNB using a 19-gauge FNB needle is superior to 19-gauge EUS-TCB needle

Radically enhanced molecular recognition

The tendency for viologen radical cations to dimerize has been harnessed to establish a recognition motif based on their ability to form extremely strong inclusion complexes with cyclobis(paraquat-p-phenylene) in its diradical dicationic redox state. This previously unreported complex involving three bipyridinium cation radicals increases the versatility of host–guest chemistry, extending its practice beyond the traditional reliance on neutral and charged guests and hosts. In particular, transporting the concept of radical dimerization into the field of mechanically interlocked molecules introduces a higher level of control within molecular switches and machines. Herein, we report that bistable and tristable [2]rotaxanes can be switched by altering electrochemical potentials. In a tristable [2]rotaxane composed of a cyclobis(paraquat-p-phenylene) ring and a dumbbell with tetrathiafulvalene, dioxynaphthalene and bipyridinium recognition sites, the position of the ring can be switched. On oxidation, it moves from the tetrathiafulvalene to the dioxynaphthalene, and on reduction, to the bipyridinium radical cation, provided the ring is also reduced simultaneously to the diradical dication