The explicit form of expectation propagation for a simple statistical model

© 2016, Institute of Mathematical Statistics. All rights reserved. We derive the explicit form of expectation propagation for approximate deterministic Bayesian inference in a simple statistical model. The model corresponds to a random sample from the Normal distribution. The explicit forms, and their derivation, allow a deeper understanding of the issues and challenges involved in practical implementation of expectation propagation for statistical analyses. No auxiliary approximations are used: we follow the expectation propagation prescription exactly. A simulation study shows expectation propagation to be more accurate than mean field variational Bayes for larger sample sizes, but at the cost of considerably more algebraic and computational effort

Age-related diffusion patterns in intervertebral disc degeneration

Poster Presentation - Give the Dog a Bone: no. 818postprintThe Joint Annual Meeting of ISMRM-ESMRMB 2010, Stockholm, Sweden, 1-7 May 2010

Lower bounds for on-line graph colorings

We propose two strategies for Presenter in on-line graph coloring games. The first one constructs bipartite graphs and forces any on-line coloring algorithm to use $2\log_2 n - 10$ colors, where $n$ is the number of vertices in the constructed graph. This is best possible up to an additive constant. The second strategy constructs graphs that contain neither $C_3$ nor $C_5$ as a subgraph and forces $\Omega(\frac{n}{\log n}^\frac{1}{3})$ colors. The best known on-line coloring algorithm for these graphs uses $O(n^{\frac{1}{2}})$ colors

Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility

While the molecular interactions between individual myosin motors and F-actin are well established, the relationship between F-actin organization and actomyosin forces remains poorly understood. Here we explore the accumulation of myosin-induced stresses within a two-dimensional biomimetic model of the disordered actomyosin cytoskeleton, where myosin activity is controlled spatiotemporally using light. By controlling the geometry and the duration of myosin activation, we show that contraction of disordered actin networks is highly cooperative, telescopic with the activation size, and capable of generating non-uniform patterns of mechanical stress. We quantitatively reproduce these collective biomimetic properties using an isotropic active gel model of the actomyosin cytoskeleton, and explore the physical origins of telescopic contractility in disordered networks using agent-based simulations

High-Performance, Wearable Thermoelectric Generator Based on a Highly Aligned Carbon Nanotube Sheet

A high-performance, wearable thermoelectric generator (TEG) was fabricated with a highly aligned carbon nanotube (CNT) sheet. The aligned CNT sheet exhibits extraordinary electrical conductivity compared to disordered CNT sheets and also can be directly fabricated as a continuous TEG without metal electrode interconnects. This provides a significant reduction in contact resistance between TE legs and electrodes compared to traditional TEGs, resulting in higher power output. In addition, the continuity of the module without any disconnected parts provides high degrees of mechanical stability and durability. This robust and scalable approach to flexible TEG fabrication paves the way for CNT applications in lightweight, flexible, and wearable electronics

Ultrashort time-to-echo MRI of the cartilagenous endplate & relationship to degenerative disc disease & Schmorl’s nodes

Session - The Short of It: no. 570Early diagnosis of CEP defects by UTE technique may provide useful information for understanding the pathogenesis of each of DDD and Schmorl¡¦s nodes (SN). The objective of this study was to assess CEP integrity in normal IVD levels, levels with degenerated IVDs and levels with SNs. Based on the UTE images, CEP defects were defined as discontinuity of high signal over 4 consecutive slices. Results showed that CEP defects were found to have a 4.5 fold increased likelihood of having DDD. No association between CEP defects and SNs was established. The effects of age and CEP defects were found to be level dependent. (abstract by publisher)postprin

Counterflow dielectrophoresis for trypanosome enrichment and detection in blood

Human African trypanosomiasis or sleeping sickness is a deadly disease endemic in sub-Saharan Africa, caused by single-celled protozoan parasites. Although it has been targeted for elimination by 2020, this will only be realized if diagnosis can be improved to enable identification and treatment of afflicted patients. Existing techniques of detection are restricted by their limited field-applicability, sensitivity and capacity for automation. Microfluidic-based technologies offer the potential for highly sensitive automated devices that could achieve detection at the lowest levels of parasitemia and consequently help in the elimination programme. In this work we implement an electrokinetic technique for the separation of trypanosomes from both mouse and human blood. This technique utilises differences in polarisability between the blood cells and trypanosomes to achieve separation through opposed bi-directional movement (cell counterflow). We combine this enrichment technique with an automated image analysis detection algorithm, negating the need for a human operator

Cracking in asphalt materials

This chapter provides a comprehensive review of both laboratory characterization and modelling of bulk material fracture in asphalt mixtures. For the purpose of organization, this chapter is divided into a section on laboratory tests and a section on models. The laboratory characterization section is further subdivided on the basis of predominant loading conditions (monotonic vs. cyclic). The section on constitutive models is subdivided into two sections, the first one containing fracture mechanics based models for crack initiation and propagation that do not include material degradation due to cyclic loading conditions. The second section discusses phenomenological models that have been developed for crack growth through the use of dissipated energy and damage accumulation concepts. These latter models have the capability to simulate degradation of material capacity upon exceeding a threshold number of loading cycles.Peer ReviewedPostprint (author's final draft

Quantitative evaluation of diffusion tensor imaging at 3T in the human lumbar intervertebral disc degeneration

Poster presentations: ST4postprintThe 2010 World Forum for Spine Research (WFSR 2010): The Intervertebral Disc, Montreal, Canada, 5-8 July 2010

Multiparametric magnetic resonance imaging of normal and degenerative lumbar intervertebral discs

Magnetic resonance imaging (MRI) has been shown to improve the diagnosis and management of patients with intervertebral disc (IVD) related disorders. Multiparametric MRI offers the possibility of noninvasively assessing multiple aspects of pathophysiological processes that exist simultaneously, thereby further assisting in patient treatment management. The purpose of this study is to determine the correlation between relaxation parameters (T1ρ and T2), diffusion properties including fractional anisotropy (FA) and mean diffusivity (MD) measured by diffusion tensor imaging (DTI) and various clinical findings in human IVD. Our results suggest that each parameter may attribute different sensitivity to tissue properties.postprin