（必須アミノ酸欠乏がヒト歯肉線維芽細胞に及ぼす生物学的影響）

大阪歯科大学Osaka Dental University博士（歯学）In this study, we aimed to investigate the effects of essential amino acid (EAA) deficiency on human gingival fibroblasts (HGFs). EAA deficiency inhibited HGF proliferation and migration, leading to impaired cellular functions. It also caused morphological changes, leading to thinner and less elongated cells, and suppressed collagen gene expression and synthesis. EAA deficiency promoted autophagy, as indicated by the increased expression levels of LC3 and decreased expression levels of p62. Overall, these findings suggest that EAA deficiency significantly impairs wound healing and tissue regeneration by HGFs. Therefore, adequate EAA intake is important to enhance tissue repair, particularly in periodontal treatment, by supporting the cellular functions necessary for healing.doctoral thesi

RETRACTED: The Chromatin-Remodeling Complex WINAC Targets a Nuclear Receptor to Promoters and Is Impaired in Williams Syndrome

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been retracted at the request of the Authors.Our paper reported that a chromatin-remodeling complex, WINAC, recruited the unliganded vitamin D receptor to promoters in cooperation with the transcription factor implicated in Williams syndrome, WSTF. The findings provided insights into the coordination between chromatin remodelers and sequence-specific transcription factors and pointed to a role of chromatin remodeling defects in Williams syndrome. We recently identified errors affecting several figure panels where original data were processed inappropriately such that the figure panels do not accurately report the original data. We believe that the most responsible course of action is to retract the paper. We sincerely apologize to the scientific community for any inconvenience that this might cause. The first author, H.K., declined to sign the retraction notice