Lasing on the D_2 line of sodium in helium atmosphere due to optical pumping on the D_1 line (up-conversion)

A new method is proposed to produce population inversion on transitions involving the ground state of atoms. The method is realized experimentally with sodium atoms. Lasing at the frequency corresponding to the sodium D_2 line is achieved in the presence of pump radiation resonant to the D_1 line with helium as a buffer gas.Comment: 4 pages, 4 figures, Late

Genomic signatures of population decline in the malaria mosquito Anopheles gambiae

Population genomic features such as nucleotide diversity and linkage disequilibrium are expected to be strongly shaped by changes in population size, and might therefore be useful for monitoring the success of a control campaign. In the Kilifi district of Kenya, there has been a marked decline in the abundance of the malaria vector Anopheles gambiae subsequent to the rollout of insecticide-treated bed nets. To investigate whether this decline left a detectable population genomic signature, simulations were performed to compare the effect of population crashes on nucleotide diversity, Tajima's D, and linkage disequilibrium (as measured by the population recombination parameter ρ). Linkage disequilibrium and ρ were estimated for An. gambiae from Kilifi, and compared them to values for Anopheles arabiensis and Anopheles merus at the same location, and for An. gambiae in a location 200 km from Kilifi. In the first simulations ρ changed more rapidly after a population crash than the other statistics, and therefore is a more sensitive indicator of recent population decline. In the empirical data, linkage disequilibrium extends 100-1000 times further, and ρ is 100-1000 times smaller, for the Kilifi population of An. gambiae than for any of the other populations. There were also significant runs of homozygosity in many of the individual An. gambiae mosquitoes from Kilifi. These results support the hypothesis that the recent decline in An. gambiae was driven by the rollout of bed nets. Measuring population genomic parameters in a small sample of individuals before, during and after vector or pest control may be a valuable method of tracking the effectiveness of interventions

Comparative effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors and human glucagon-like peptide-1 (GLP-1) analogue as add-on therapies to sulphonylurea among diabetes patients in the Asia-Pacific region: a systematic review

The prevalence of diabetes mellitus is rising globally, and it induces a substantial public health burden to the healthcare systems. Its optimal control is one of the most significant challenges faced by physicians and policy-makers. Whereas some of the established oral hypoglycaemic drug classes like biguanide, sulphonylureas, thiazolidinediones have been extensively used, the newer agents like dipeptidyl peptidase-4 (DPP-4) inhibitors and the human glucagon-like peptide-1 (GLP-1) analogues have recently emerged as suitable options due to their similar efficacy and favorable side effect profiles. These agents are widely recognized alternatives to the traditional oral hypoglycaemic agents or insulin, especially in conditions where they are contraindicated or unacceptable to patients. Many studies which evaluated their clinical effects, either alone or as add-on agents, were conducted in Western countries. There exist few reviews on their effectiveness in the Asia-Pacific region. The purpose of this systematic review is to address the comparative effectiveness of these new classes of medications as add-on therapies to sulphonylurea drugs among diabetic patients in the Asia-Pacific countries. We conducted a thorough literature search of the MEDLINE and EMBASE from the inception of these databases to August 2013, supplemented by an additional manual search using reference lists from research studies, meta-analyses and review articles as retrieved by the electronic databases. A total of nine randomized controlled trials were identified and described in this article. It was found that DPP-4 inhibitors and GLP-1 analogues were in general effective as add-on therapies to existing sulphonylurea therapies, achieving HbA1c reductions by a magnitude of 0.59–0.90% and 0.77–1.62%, respectively. Few adverse events including hypoglycaemic attacks were reported. Therefore, these two new drug classes represent novel therapies with great potential to be major therapeutic options. Future larger-scale research should be conducted among other Asia-Pacific region to evaluate their efficacy in other ethnic groups

Towards Standardization of Quantitative Retinal Vascular Parameters:Comparison of SIVA and VAMPIRE Measurements in the Lothian Birth Cohort 1936

Purpose: Semiautomated software applications derive quantitative retinal vascular parameters from fundus camera images. However, the extent of agreement between measurements from different applications is unclear. We evaluate the agreement between retinal measures from two software applications, the Singapore "I" Vessel Assessment (SIVA) and the Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE), and examine respective associations between retinal and systemic outcomes.Method: Fundus camera images from 665 Lothian Birth Cohort 1936 participants were analyzed with SIVA and VAMPIRE. Intraclass correlation coefficients (ICC) and Bland-Altman plots assessed agreement between retinal parameters: measurements of vessel width, fractal dimension, and tortuosity. Retinal-systemic variable associations were assessed with Pearson's correlation, and intersoftware correlation magnitude differences were examined with Williams's test.Results: ICC values indicated poor to limited agreement for all retinal parameters (0.159-0.410). Bland-Altman plots revealed proportional bias in the majority, and systematic bias in all measurements. SIVA and VAMPIRE measurements were associated most consistently with systemic variables relating to blood pressure (SIVAr's from -0.122 to -0.183; VAMPIREr's from -0.078 to -0.177). Williams's tests indicated significant differences in the magnitude of association between retinal and systemic variables for 7 of 77 comparisons (P&lt; 0.05).Conclusions: Agreement between two common software applications was poor. Further studies are required to determine whether associations with systemic variables are software-dependent.Translational Relevance: Standardization of the measurement of retinal vascular parameters is warranted to ensure that they are reliable and application-independent. This would be an important step towards realizing the potential of the retina as a source of imaging-derived biomarkers that are clinically useful.</p

Determining reliability functions of steam turbine in power plant 'Nikola Tesla, block a4'

Determination of reliability indicators of steam turbine system in the thermal power plant 'Nikola Tesla, Block A4'during useful life period is based on a ten-year operational database. By implementation of mathematical theory of reliability to exploitation research data and using simple and complex two-parameter Weibull distribution, the theoretical reliability functions of the considered system are determined. The graphical method is applied to quantitatively determine reliability indicators. Obtained probabilistic laws of failure density and failure rate, according to which the random variable behaves, do not coincide completely with empirical distributions, regardless of whether the theoretical functions are obtained by simple or complex Weibull distribution

Determining reliability functions of steam turbine in power plant 'Nikola Tesla, block a4'

Determination of reliability indicators of steam turbine system in the thermal power plant 'Nikola Tesla, Block A4'during useful life period is based on a ten-year operational database. By implementation of mathematical theory of reliability to exploitation research data and using simple and complex two-parameter Weibull distribution, the theoretical reliability functions of the considered system are determined. The graphical method is applied to quantitatively determine reliability indicators. Obtained probabilistic laws of failure density and failure rate, according to which the random variable behaves, do not coincide completely with empirical distributions, regardless of whether the theoretical functions are obtained by simple or complex Weibull distribution

Risk assessment based on analytical evaluation of structural integrity and life of drilling rig pipe

Risk assessment procedure based on structural integrity evaluation has been applied to oil drilling rig pipe. The new concept based on application of structural integrity evaluation to assess risk level according to probability and consequence of failure was used. Analytical expressions for surface cracks are used to calculate stress intensity factors for different crack geometries. Oil drilling rig welded pipe integrity has been evaluated analytically by simple application of the Failure Assessment Diagramme (FAD), i.e. by using the ratio of linear elastic fracture mechanics parameter, KI, and its critical value, KIc, in relation with the ratio of applied stress and its critical value, to define the point in FAD. Probability of failure is then taken according to the position of the point in the FAD, corresponding to oil drilling rig welded pipe data. The same logic is employed in the case of cyclic loading, i.e. fatigue crack growth. In that case, structural life is estimated by using Paris law to calculate crack length vs. number of cycles, to be used in risk assessment procedure and by managers to make decision about further use of damaged pipes, based on data provided by engineers

Risk assessment based on analytical evaluation of structural integrity and life of drilling rig pipe

Risk assessment procedure based on structural integrity evaluation has been applied to oil drilling rig pipe. The new concept based on application of structural integrity evaluation to assess risk level according to probability and consequence of failure was used. Analytical expressions for surface cracks are used to calculate stress intensity factors for different crack geometries. Oil drilling rig welded pipe integrity has been evaluated analytically by simple application of the Failure Assessment Diagramme (FAD), i.e. by using the ratio of linear elastic fracture mechanics parameter, KI, and its critical value, KIc, in relation with the ratio of applied stress and its critical value, to define the point in FAD. Probability of failure is then taken according to the position of the point in the FAD, corresponding to oil drilling rig welded pipe data. The same logic is employed in the case of cyclic loading, i.e. fatigue crack growth. In that case, structural life is estimated by using Paris law to calculate crack length vs. number of cycles, to be used in risk assessment procedure and by managers to make decision about further use of damaged pipes, based on data provided by engineers

Genomic Runs of Homozygosity Record Population History and Consanguinity

The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin marriages have long runs of homozygosity (ROH), while the numerous shorter tracts relate to shared ancestry tens and hundreds of generations ago. Human populations have experienced a wide range of demographic histories and hold diverse cultural attitudes to consanguinity. In a global population dataset, genome-wide analysis of long and shorter ROH allows categorisation of the mainly indigenous populations sampled here into four major groups in which the majority of the population are inferred to have: (a) recent parental relatedness (south and west Asians); (b) shared parental ancestry arising hundreds to thousands of years ago through long term isolation and restricted effective population size (N(e)), but little recent inbreeding (Oceanians); (c) both ancient and recent parental relatedness (Native Americans); and (d) only the background level of shared ancestry relating to continental N(e) (predominantly urban Europeans and East Asians; lowest of all in sub-Saharan African agriculturalists), and the occasional cryptically inbred individual. Moreover, individuals can be positioned along axes representing this demographic historic space. Long runs of homozygosity are therefore a globally widespread and under-appreciated characteristic of our genomes, which record past consanguinity and population isolation and provide a distinctive record of the demographic history of an individual's ancestors. Individual ROH measures will also allow quantification of the disease risk arising from polygenic recessive effects

Crack resistance of aluminium alloy friction stir welded joint

Charpy testing is conducted on a high-speed data acquisition instrument, using instrumented pendulum to separate energies for crack initiation and propagation. The J-R curves are used to determine JIc, as the measure of fracture toughness. The Taguchi method with a special design of orthogonal matrices to reduce the number of experiments to a reasonable level has been applied