Evaluation of cellular proliferation as prognostic indicator for canine cutaneous mast cell tumors

Este estudo teve como objetivo avaliar o valor prognóstico de marcadores de proliferação celular em casos de mastocitomas cutâneos caninos. Vinte e três casos foram analisados quanto à expressão imuno-histoquímica de Ki67 e do Antígeno Nuclear de Proliferação Celular (PCNA), sendo subsequentemente acompanhados clinicamente. Observou-se que a expressão de Ki67 mantém relação negativa com a tradicional graduação histopatológica (p= 0,0418; p<0,05 entre os graus I e III), sendo um indicador confiável para o tempo de sobrevida pós-cirúrgica (p=0,0089). A imunoexpressão de PCNA, apesar de estar correlacionada à marcação por Ki67, não apresentou valores estatisticamente significantes na predição da mortalidade em função da doença e do tempo de sobrevida pós-cirúrgico. Os resultados obtidos confirmam que informações sobre a atividade proliferativa tumoral pela detecção imuno-histoquímica de Ki67 podem incrementar a classificação de mastocitomas cutâneos caninos quanto à malignidade.This study evaluated the prognostic value of cell proliferation markers for canine cutaneous mast cell tumor cases. Twenty-three cases were analyzed with regard to immuno-histochemical expression of Ki67 and Proliferating Cell Nuclear Antigen (PCNA), and were clinically followed up. Ki67 expression was related to the traditional histopathological grading (p= 0.0418; p<0.05 between grades I and III), and was a reliable indicator of post-surgical survival (p=0.0089). PCNA immunoexpression did not show statistically significant values in the prediction of disease-related mortality and survival, although it is correlated to Ki67 expression. These results confirm that information about tumoral proliferative activity through Ki67 immunohistochemical detection can improve canine cutaneous mast cell tumor grading with regard to malignancy

Investigation on Performance Advantage of Functionally Integrated Magnetic Components in Decentralised Power Electronic Applications

Zugleich: Dissertation, Universität Kassel, 201

Controlled magnetic devices in power electronic applications

Proceedings der Konferenz 19th European Conference on Power Electronics and Applications (EPE'17 ECCE Europe) vom 11-14 Sept. 2017 in Warschau, Polen.Parts of the work presented in this paper have been supported by the German Federal Ministry for Economic Affairs and Energy (BMWi). Project funding reference number: 0324106A

Metamorfoses do simbólico no brasil rural – As transformações do início do século XXI vistas por meio de um personagem clássico da formação do Brasil, o caipira

In the analysis of Brazilian transfonnations of this 21st century there are polarizations involving the praise of unprecedented changes in the history of the country and the argument about their limited scope in the contemporary crisis. This article circumvents these extremes by stating that the period expresses changes in the bases of domination, here focused on the metamorphoses of the “caipira ” in rural and inland Brazil. This is portrayed in classic studies on Cunha and Bofete (SP) and revisited atpresent, highlighting three aspects: the 2000s recompose the “caipira’in the social hierarchy, combining changes and updates of old structures of domination; new ruralities show heterogeneous processes of preservation of the “caipira's” autonomy and tradition under theforms of contractualization of capitalist rationality and of the urban and post-industrial world; aspects emphasized by the classics of Brazilian configuration are supported if understood from the perspective of metamorphoses and material and symbolic articulations, interdependencies between local and extra local, and interpenetrations between past and present.En el análisis de las transformaciones brasileñas de este siglo XXI hay polarizaciones que implican elogios de cambios sin precedentes en la historia del país y el argumento sobre su alcance limitado en la crisis contemporánea. Este artículo evita estos extremos al afirmar que el período expresa cambios en las bases de la dominación, centrados en las metamorfosis del “caipira” en las zonas rurales y del interior de Brasil. Esto se retrata en estudios clásicos sobre Cunha y Bofete (SP), así como en las revisiones actuales, destacando tres aspectos: los años 2000 recomponen el “caipira” en la jerarquía social, combinando cambios y actualizaciones de viejas estructuras de dominación; las nuevas ruralidades muestran procesos heterogéneos de preservación de la autonomía y tradición del “caipira” bajo formas de contractualización de la racionalidad capitalista y del mundo urbano y postindustrial; los aspectos enfatizados por los clásicos de la formación brasileña se sostienen si se comprenden desde la perspectiva de las metamorfosis y las articulaciones de lo material y lo simbólico, las interdependencias entre lo local y lo extra local, y las interpenetraciones entre el pasado y el presente.Na análise das transformações brasileiras do século XXI há polarizações envolvendo enaltecimento de mudanças inéditas na história do país e argumentação sobre o alcance limitado destas na crise contemporânea. Este artigo contorna estes extremos afirmando que o período expressa mudanças nas bases da dominação, focalizadas nas metamorfoses do caipira no Brasil rural e interiorano. Esta é retratada em estudos clássicos sobre Cunha-SP e Bofete-SP e revisitada no presente, destacando-se três aspectos: os anos 2000 recompõem o caipira na hierarquia social, combinando alterações e atualizações de velhas estruturas de dominação; novas ruralidades evidenciam processos heterogêneos de preservação de autonomia e tradição do caipira sob formas de contratualização da racionalidade capitalista e do mundo urbano e pós-industrial; aspectos ressaltados pelos clássicos da formação brasileira têm sustentação se entendidos sob o prisma das metamorfoses e articulações do material e do simbólico, das interdependências entre local e extra local, e das interpenetrações entre passado e presente

Innovative solutions to sticky situations: Antiadhesive strategies for treating bacterial infections

ABSTRACT Bacterial adherence to host tissue is an essential process in pathogenesis, necessary for invasion and colonization and often required for the efficient delivery of toxins and other bacterial effectors. As existing treatment options for common bacterial infections dwindle, we find ourselves rapidly approaching a tipping point in our confrontation with antibiotic-resistant strains and in desperate need of new treatment options. Bacterial strains defective in adherence are typically avirulent and unable to cause infection in animal models. The importance of this initial binding event in the pathogenic cascade highlights its potential as a novel therapeutic target. This article seeks to highlight a variety of strategies being employed to treat and prevent infection by targeting the mechanisms of bacterial adhesion. Advancements in this area include the development of novel antivirulence therapies using small molecules, vaccines, and peptides to target a variety of bacterial infections. These therapies target bacterial adhesion through a number of mechanisms, including inhibition of pathogen receptor biogenesis, competition-based strategies with receptor and adhesin analogs, and the inhibition of binding through neutralizing antibodies. While this article is not an exhaustive description of every advancement in the field, we hope it will highlight several promising examples of the therapeutic potential of antiadhesive strategies.</jats:p

Recognition of landscapes in Santo André, SP, Brazil: an experience of Inventory of cultural goods

This article presents the experience that is being held with a view to organising the Inventory of cultural goods of Santo André, city of São Paulo metropolitan region, inserted in an area called popularly of ABC. This is the presentation of methodological procedures adopted in a given circumference - central area of the city. In this text are demonstrated: how to approach the area, the recognition of landscapes present making use of the concept of cultural landscape, the researches undertaken and the results obtained.Este artigo apresenta a experiência que vem sendo realizada com vistas à organização do Inventário de Bens Culturais de Santo André, cidade da região metropolitana de São Paulo, inserida em uma área denominada popularmente de ABC. Trata-se da apresentação dos procedimentos metodológicos adotados em um perímetro determinado - área central da cidade. Neste texto são demonstrados: a forma de abordagem da área, o reconhecimento das paisagens presentes fazendo-se uso do conceito de paisagem cultural, as pesquisas desenvolvidas e os resultados obtidos

Long-Term Treatment with Aqueous Garlic and/or Tomato Suspensions Decreases Ehrlich Ascites Tumors

We evaluated the preventive and therapeutic effects of aqueous suspensions of garlic, tomato, and garlic + tomato in the development of experimental Ehrlich tumors in mice. the aqueous suspensions (2%) were administered over a short term for 30 days before tumor inoculation and 12 days afterward, and suspensions at 6% were administered for 180 days before inoculation and for 12 days afterward. the volume, number, and characteristics of the tumor cells and AgNOR counts were determined to compare the different treatments. Aqueous 6% suspensions of garlic, tomato, and garlic + tomato given over the long term significantly reduced tumor growth but when given over the short term, they did not alter tumor growth.Paulista Univ UNIP, BR-05622001 São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Pharmacol, BR-04021001 São Paulo, BrazilUniv Metodista São Paulo, BR-09641000 Sao Bernardo Do Campo, SP, BrazilFed Univ São Paulo UNIFESP, Dept Pharmacol, BR-04021001 São Paulo, BrazilWeb of Scienc

Assessment of foodservice quality and identification of improvement strategies using hospital foodservice quality model

The purposes of this study were to assess hospital foodservice quality and to identify causes of quality problems and improvement strategies. Based on the review of literature, hospital foodservice quality was defined and the Hospital Foodservice Quality model was presented. The study was conducted in two steps. In Step 1, nutritional standards specified on diet manuals and nutrients of planned menus, served meals, and consumed meals for regular, diabetic, and low-sodium diets were assessed in three general hospitals. Quality problems were found in all three hospitals since patients consumed less than their nutritional requirements. Considering the effects of four gaps in the Hospital Foodservice Quality model, Gaps 3 and 4 were selected as critical control points (CCPs) for hospital foodservice quality management. In Step 2, the causes of the gaps and improvement strategies at CCPs were labeled as "quality hazards" and "corrective actions", respectively and were identified using a case study. At Gap 3, inaccurate forecasting and a lack of control during production were identified as quality hazards and corrective actions proposed were establishing an accurate forecasting system, improving standardized recipes, emphasizing the use of standardized recipes, and conducting employee training. At Gap 4, quality hazards were menus of low preferences, inconsistency of menu quality, a lack of menu variety, improper food temperatures, and patients' lack of understanding of their nutritional requirements. To reduce Gap 4, the dietary departments should conduct patient surveys on menu preferences on a regular basis, develop new menus, especially for therapeutic diets, maintain food temperatures during distribution, provide more choices, conduct meal rounds, and provide nutrition education and counseling. The Hospital Foodservice Quality Model was a useful tool for identifying causes of the foodservice quality problems and improvement strategies from a holistic point of view