Sustainability in fasion as inspiration for textile design

Istraživanjem problema održivosti mode, jasno je da su nam potrebna riješenja kako bi smanjili štetu koju modna industrija prouzrokuje svojom proizvodnjom i stvaranjem otpada. Kroz povratak u prošlost i ponovno razmatranje starih tehnika bojadisanja te korištenje biljaka koje su najbolji i najraznolikiji izvor bojila, istražujem nove tehnike i mogučnosti printanja tekstila bez kemikalija te težim recikliranju 100% upotrebljene sirovine što rezultira stvaranjem kolekcije tekstila zero-waste (nula otpada) kvalitete.By researching the problem of sustainability of fashion, it is clear that we need solutions to reduce the damage caused by the fashion industry through its production and waste generation. Through returning to the past and reconsidering the old dyeing techniques and the use of the best and most colorful plants, I research the new techniques and the possibilities of printing textiles without chemicals and trying to recyclle 100% of the raw material used, which results with the creation of a zero-waste textile collection

Demonstration experiments in physics education: Energy change

U okviru rada diskutiraju se metode izvedbe nastave fizike koje bi trebale rezultirati boljim razumijevanjem nastavnih sadržaja i stjecanjem trajnih znanja. Pri tome je ključan fizikalni pokus kao središnji element nastavnog sata fizike. Na primjeru teme o pretvorbi energije temeljene na zakonu očuvanja energije, daje se pregled odabranih demonstracijskih pokusa kojima bi se mogli postići navedeni ciljevi.In this work, methods of performing physical teaching are discussed, which should result in a better understanding of teaching content and the acquisition of persistent knowledge. The physical experiment has a key role as the central element of the physics teaching. In an example of energy-based transformation topic, an overview of selected demonstration experiments is provided to achieve these goals

A Simple Non-Markovian Computational Model of the Statistics of Soccer Leagues: Emergence and Scaling effects

We propose a novel algorithm that outputs the final standings of a soccer league, based on a simple dynamics that mimics a soccer tournament. In our model, a team is created with a defined potential(ability) which is updated during the tournament according to the results of previous games. The updated potential modifies a teams' future winning/losing probabilities. We show that this evolutionary game is able to reproduce the statistical properties of final standings of actual editions of the Brazilian tournament (Brasileir\~{a}o). However, other leagues such as the Italian and the Spanish tournaments have notoriously non-Gaussian traces and cannot be straightforwardly reproduced by this evolutionary non-Markovian model. A complete understanding of these phenomena deserves much more attention, but we suggest a simple explanation based on data collected in Brazil: Here several teams were crowned champion in previous editions corroborating that the champion typically emerges from random fluctuations that partly preserves the gaussian traces during the tournament. On the other hand, in the Italian and Spanish leagues only a few teams in recent history have won their league tournaments. These leagues are based on more robust and hierarchical structures established even before the beginning of the tournament. For the sake of completeness, we also elaborate a totally Gaussian model (which equalizes the winning, drawing, and losing probabilities) and we show that the scores of the "Brasileir\~{a}o" cannot be reproduced. Such aspects stress that evolutionary aspects are not superfluous in our modeling. Finally, we analyse the distortions of our model in situations where a large number of teams is considered, showing the existence of a transition from a single to a double peaked histogram of the final classification scores. An interesting scaling is presented for different sized tournaments.Comment: 18 pages, 9 figure

Power in time: The influence of power posing on metaphoric perspectives on time

In English, the Moving Ego metaphor conceptualizes the ego as moving forward through time and the Moving Time metaphor construes time as moving forward toward the ego. Recent research has provided evidence that people’s metaphorical perspectives on deictic time may be influenced by experiences—both spatial and non-spatial—that are connected to approach motivations (Moving Ego) and avoidance motivations (Moving Time). We extend this research further, asking whether there are differences in preferred temporal perspective between those who exhibit higher and lower degrees of power, as high power has been connected to approach motivations and low power, to avoidance motivations. Across two temporal tasks, participants in our study who adopted high-power poses demonstrated a greater preference for the Moving Ego perspective, compared to those adopting low-power poses. These results suggest an embodied connection between approach and avoidance motivations and the Moving Ego and Moving Time metaphors, respectively

Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways

A subset of high-risk Human Papillomaviruses (HPVs) are the causative agents of a large number of human cancers, of which cervical is the most common. Two viral oncoproteins, E6 and E7, contribute directly towards the development and maintenance of malignancy. A characteristic feature of the E6 oncoproteins from cancer-causing HPV types is the presence of a PDZ binding motif (PBM) at its C-terminus, which confers interaction with cellular proteins harbouring PDZ domains. Here we show that this motif allows E6 interaction with Sorting Nexin 27 (SNX27), an essential component of endosomal recycling pathways. This interaction is highly conserved across E6 proteins from multiple high-risk HPV types and is mediated by a classical PBM-PDZ interaction but unlike many E6 targets, SNX27 is not targeted for degradation by E6. Rather, in HPV-18 positive cell lines the association of SNX27 with components of the retromer complex and the endocytic transport machinery is altered in an E6 PBM-dependent manner. Analysis of a SNX27 cargo, the glucose transporter GLUT1, reveals an E6-dependent maintenance of GLUT1 expression and alteration in its association with components of the endocytic transport machinery. Furthermore, knockdown of E6 in HPV-18 positive cervical cancer cells phenocopies the loss of SNX27, both in terms of GLUT1 expression levels and its vesicular localization, with a concomitant marked reduction in glucose uptake, whilst loss of SNX27 results in slower cell proliferation in low nutrient conditions. These results demonstrate that E6 interaction with SNX27 can alter the recycling of cargo molecules, one consequence of which is modulation of nutrient availability in HPV transformed tumour cells

Contribution of Human Papillomavirus E6 PDZ-Binding Activity to Virus-Induced Pathogenesis

It is clear that the targeting of PDZ-containing substrates by E6 is important for the normal viral life cycle and for the progression to malignancy. However, which of these PDZ domain-containing proteins is relevant for HPV pathology is still elusive. In this study, we provide the evidence that different PDZ domain-containing proteins are differentially targeted by E6. With these experiments, we identified MAGI-1 as a sensitive proteolytic substrate for both the HPV-16 and HPV-18 E6 oncoproteins. We show that E6 promotes the degradation of membrane-bound and nuclear pools of MAGI-1, and the silencing of E6 expression resulted in the MAGI-1-mediated junctional recruitment of ZO-1. Using a mutant MAGI-1, resistant to E6-mediated degradation, we also show that its expression in HeLa cells also promotes membrane recruitment of the tight junction-associated proteins ZO-1 and PAR3, represses cell proliferation and promotes apoptosis. These findings suggest that E6-mediated inhibition of MAGI-1 function perturbs tight junction assembly, with concomitant stimulation of proliferation and inhibition of apoptosis. We also found that the cell polarity regulator hScrib is differentially targeted by HPV-16 and HPV-18 Ed-mediated degradation. Surprisingly, we found that residual levels of hScrib expression are required for the maintenance of high levels of HPV-18 E6 expression in HeLa cells. This is not due to an effect on E6 stability or transcription, but rather is due to an effect upon E6 translation. We provide evidence that hScrib and E6 both regulate the PI3K/mTORC1 pathway, and that hScrib might regulate cap-dependent translation through the modulation of the mTORCl effector S6 kinase. This provides an unexpected role for hScrib in the regulation of tissue homeostasis, and provides further evidence that E6, by fine-tuning the levels of expression of its different cellular substrates, can impact upon a wide range of biological processes implicated in the pathogenesis of cervical cancer

Influence of age on the clinical outcomes of coronary revascularisation for the treatment of patients with multivessel de novo coronary artery lesions: sirolimus-eluting stent vs. coronary artery bypass surgery and bare metal stent, insight from the multicentre randomised Arterial Revascularisation Therapy Study Part I (ARTS-I) and Part II (ARTS-II)

peer reviewedAims: We sought to evaluate the prognostic impact of age on the procedural results and subsequent clinical outcomes in patients with multivessel disease (MVD) treated either by coronary artery bypass surgery (CABG) or by percutaneous coronary intervention (PCI) with or without drug eluting stents, based on data of the Arterial Revascularisation Therapies Study (ARTS) part I and part II. The potential influence of age in determining the most appropriate revascularisation strategy for patients with MVD is largely unknown. Methods and results: Three year clinical outcome of ARTS I patients randomised to PCI with bare metal stent (BMS) (n= 600) or CABG (n= 605), and matched patients treated by PCI with sirolimus-eluting stents (SES) in ARTS II (n= 607) were reviewed according to four age quartiles. Endpoints were measured in terms of major adverse cardiac and cerebrovascular events MACCE) during hospital stay and up to three years. The frequency of female, diabetes, hypertension, peripheral vascular disease, pulmonary disease, as well as lesion complexity increased with age. At three years, MACCE free survival was comparable between patients treated by CABG or SES PCI, regardless of age quartile. The incidence of MACCE was higher among ARTS I BMS treated patients in all but the second age quartile. This was primarily related to a higher need for repeat revascularisation among BMS treated patients. However, age, which emerged as a strong independent predictor of MACCE following CABG (p<0.005), was not predictive of adverse events following PCI. Conversely, diabetes was the strongest independent predictor of MACCE among PCI treated patients (p<0.02), but didn’t affect three-year outcomes following CABG. Conclusions: Age seems to influence the CABG outcome in-hospital but not PCI. PCI-SES could offer lower immediate risk in patients with MVD and comparable long-term outcome as CABG especially in older patients. The worst outcome of PCI-BMS group is primarily related to the need for repeat revascularisation. Diabetes is the most important predictor of MACCE following PCI

Are Temporal Concepts Embodied? A Challenge for Cognitive Neuroscience

Is time an embodied concept? People often talk and think about temporal concepts in terms of space. This observation, along with linguistic and experimental behavioral data documenting a close conceptual relation between space and time, is often interpreted as evidence that temporal concepts are embodied. However, there is little neural data supporting the idea that our temporal concepts are grounded in sensorimotor representations. This lack of evidence may be because it is still unclear how an embodied concept of time should be expressed in the brain. The present paper sets out to characterize the kinds of evidence that would support or challenge embodied accounts of time. Of main interest are theoretical issues concerning (1) whether space, as a mediating concept for time, is itself best understood as embodied and (2) whether embodied theories should attempt to bypass space by investigating temporal conceptual grounding in neural systems that instantiate time perception

Differences in self-regulated learning between gifted students, students with special needs and other students in Slovenian schools

Self-regulated learning strategies play a crucial role in learning progress and academic achievement of different groups of students. The purpose of the present study is to investigate differences in the use of self-regulatory strategies among a sample of 1,495 students, aged 12 to 15 years, representing three groups: gifted students, students with special needs, and other students. The theoretical framework for the study is Pintrich\u27s (1991) model of self-regulated learning. Data were collected using the Motivated Strategies for Learning Questionnaire (MSLQ). Results indicated that gifted students scored significantly higher on the MSLQ subscales of motivation and learning strategies than students with special needs and other peers. Special needs students reported lower intrinsic and extrinsic goal orientation and weaker self-efficacy in learning and achievement than other students. There were no significant differences between these two groups on the MSLQ learning strategies subscales. Positive and statistically significant associations between the MSLQ subscales and final grades in three school subjects (Slovenian, mathematics, and foreign language) were also confirmed. We discuss the implications of our findings for future research and the educational context that contributes most to the development of self-regulated learning in all groups of students