1,574 research outputs found
Heterogeneous conductivity parameters in a one dimensional fuel cell model
A model of one dimensional fuel cells is investigated, where the material inhomogeneities in the cathode are taken into account. We use the results in some preceding studies to describe the dynamics of the chemical reactions and transport of ions. A corresponding governing equation is derived for the numerical simulations. We apply an explicit-implicit time integration and Richardson extrapolation technique to increase the accuracy of the approximations. The efficiency of the method is demonstrated using a non-trivial test problem with real parameters. Numerical simulations are executed in presence of inhomogeneous conductivities and their effect on the cell potential is investigated
Pengujian Ketetapan Majelis Permusyawaratan Rakyat Dalam Sistem Ketatanegaraan Republik Indonesia
Pengujian Ketetapan Majelis Permusyawaratan Rakyat Dalam Sistem Ketatanegaraan Republik Indonesia meliputi antara lain: pertama, tujuan penelitian adalah untuk mengetahui bagaimana kedudukan hukum Ketetapan MPR dalam tata urutan peraturan Perundang-undangan. Kedua, mengenai pengujian ketetapan MPR yang masih berlaku dan lembaga mana yang berwenang menguji Ketetapan MPR yang bertentangan dengan Undang-Undang Dasar Negara Republik Indonesia Tahun 1945. Ketiga, metode penelitian adalah metode penelitian yuridis normatif dengan menggunakan pendekatan peraturan Perundang-undangan, pendekatan konseptual, pengumpulan bahan hukum yang dilakukan dengan studi kepustakaan. Keempat, hasil penelitian terungkap bahwa kedudukan hukum ketetapan MPR dalam sistem hukum nasional adalah berada setingkat dibawah Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 dan set dan DPR sesuai dengan ketentuan Pasal 4 Ketetapan MPR Nomor I/MPR/2003.ingkat berada diatas Undang-Undang. Dengan kedudukan demikian membawa konsekuensi yuridis bahwa secara materil Ketetapan MPR tersebut dapat dilakukan pengujian dengan batu uji Undang-Undang Dasar Negara Republik Indonesia Tahun 1945. Pengujian Ketetapan MPR dilakukan dengan mekanisme legislativ review, dan lembaga yang berwenang melakukan pengujian ketetapan MPR adalah MPR sendiri sebagai pembentuknya sesuai dengan Ketetapan MPR Nomor III/MPR/200
Preparing Teacher Candidates to Serve Students From Diverse Backgrounds: Triggering Transformative Learning Through Short-Term Cultural Immersion
This study followed 24 teacher candidates in a short-term cultural immersion field experience designed to help them reflect on their assumptions and perspectives in order to better understand the culturally, ethnically, and linguistically diverse students they will teach. Qualitative methods were informed by a phenomenological research approach to examine candidates’ transformative learning experiences in a cultural immersion context. The findings are discussed within a three-stage framework of transformative learning: triggering experiences, frame of reference examination, and transformative change
Prediction of gene–phenotype associations in humans, mice, and plants using phenologs
All authors are with the Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA. -- Ulf Martin Singh-Blom is with the Program in Computational and Applied Mathematics, The University of Texas at Austin, Austin, TX 78712, USA, and th Unit of Computational Medicine, Department of Medicine, Karolinska Institutet, Stockholm 171 76, Sweden. -- Kriston L. McGary is with the Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.Background: Phenotypes and diseases may be related to seemingly dissimilar phenotypes in other species by means of the orthology of underlying genes. Such “orthologous phenotypes,” or “phenologs,” are examples of deep homology, and may be used to predict additional candidate disease genes.
Results: In this work, we develop an unsupervised algorithm for ranking phenolog-based candidate disease genes through the integration of predictions from the k nearest neighbor phenologs, comparing classifiers and weighting functions by cross-validation. We also improve upon the original method by extending the theory to paralogous phenotypes. Our algorithm makes use of additional phenotype data — from chicken, zebrafish, and E. coli, as well as new datasets for C. elegans — establishing that several types of annotations may be treated as phenotypes. We demonstrate the use of our algorithm to predict novel candidate genes for human atrial fibrillation (such as HRH2, ATP4A, ATP4B, and HOPX) and epilepsy (e.g., PAX6 and NKX2-1). We suggest gene candidates for pharmacologically-induced seizures in mouse, solely based on orthologous phenotypes from E. coli. We also explore the prediction of plant gene–phenotype associations, as for the Arabidopsis response to vernalization phenotype.
Conclusions: We are able to rank gene predictions for a significant portion of the diseases in the Online Mendelian Inheritance in Man database. Additionally, our method suggests candidate genes for mammalian seizures based only on bacterial phenotypes and gene orthology. We demonstrate that phenotype information may come from diverse sources, including drug sensitivities, gene ontology biological processes, and in situ hybridization annotations. Finally, we offer testable candidates for a variety of human diseases, plant traits, and other classes of phenotypes across a wide array of species.Center for Systems and Synthetic BiologyInstitute for Cellular and Molecular [email protected]
Highly Stable and Active Catalyst for Sabatier Reactions
Highly active Ru/TiO2 catalysts for Sabatier reaction have been developed. The catalysts have shown to be stable under repeated shutting down/startup conditions. When the Ru/TiO2 catalyst is coated on the engineered substrate Fe-CrAlY felt, activity enhancement is more than doubled when compared with an identically prepared engineered catalyst made from commercial Degussa catalyst. Also, bimetallic Ru-Rh/TiO2 catalysts show high activity at high throughput
Professional practices, training, and funding mechanisms: A survey of pediatric primary care psychologists
The integration of mental health services in primary care settings has expanded rapidly in recent years with psychologists being at the forefront of efforts to promote healthy behaviors, reduce disease, and care for behavioral, emotional, and developmental needs to promote overall health and well-being for children and families (Asarnow, Kolko, Miranda,&Kazak, 2017; Stancin& Perrin, 2014). While there are many psychologists working in pediatric primary care (PPC), little is known about the specific activities that these psychologists engage in, the training they receive, or funding mechanisms that support their work. This study sought to address this gap in the literature through a survey of psychologists working in PPC. An anonymous online survey was disseminated to members of professional organizations and listservs who were identified as having interest in PPC. Psychologists (N-65) currently practicing in PPC completed the survey by reporting on clinical roles and practices, professional training, practice settings, and funding supports in PPC settings. Results indicate that psychologists assume a number of roles in PPC including providing individual and family therapy, conducting screenings for child mental health concerns, and providing consultation to medical colleagues. Many psychologists also provide supervision and offer educational opportunities for those in related fields, such as medicine and social work. Engagement in research activities was identified as a secondary activity. It was reported that a number of clinical activities were not billed for on a regular basis. Additional areas of research will be discussed along with implications for clinical services in PPC.. © 2017 American Psychological Association
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