I-Corps as a Training Tool for New Technology Development

Innovation Corps is a program developed by the National Science Foundation where university scientists and students learn entrepreneurial skills that enable them to take their research be­yond the laboratory and discover the commercial potential of their innovation. I-Corps Sites, located at several universities, offer shortened curricula to qualify teams for participation in the national I-Corps program (NSF I-Corps Teams). The core topics covered in I-Corps Sites’ curricula teach teams about the importance of cus­tomer discovery; the teams are expected to leave the lab and personally interview 20+ potential customers to determine their product-market fit

Optimization of Oleosin 30G Production for Echocardiography

Provided they are uniform in size, monodisperse microbubbles behave as contrast agents to enhance echocardiographic imaging. Compounds like Oleosin 30G with surfactant-like properties help stabilize microbubbles - thereby ensuring their uniform size. Designed herein is an industrial-scale plant to produce medical-grade Oleosin 30G with a process consisting of three steps: 1) upstream production via recombinant E. coli in an integrated batch bioprocessing model, 2) downstream purification, and 3) processing by microfluidic manifolds. Ultimately Oleosin 30G-coated microbubbles are manufactured, ready for injection within one month. Owing to its unique properties and cost-effective production, Oleosin 30G has the potential to outcompete current market leader Definity®. Altogether, overall yield of Oleosin 30G constitutes 7.39 kg/year to provide for 100% market saturation. Financial analysis indicates pursuing Oleosin 30G for echocardiography applications is very profitable with a 296% return on investment and holds potential for production expansion should the market demand increase

Problems in designig and rebuilding of bridges and culverts

W pracy przedstawiono, na wybranych przykładach zrealizowanych mostów i przepustów, problemy związane z ich projektowaniem, modernizacją i przebudową. Szczególną uwagę zwrócono na aspekty uwarunkowań środowiskowych, estetycznych i wymagań co do trwałości zarówno nowoprojektowanych jak i remontowanych obiektów mostowych.The paper covers problems in designing and rebuilding of bridges and culverts. All bridges should be designed with taking into consideration environmental determinants and requirements of durability. On selected examples of existing objects like bridges and culverts there were shown the practical aspects of their designing and rebuilding

The Polish Immigration Committee in the United States: A Historical Study of the American Committee for the Relief of Polish Immigrants, 1947-1952

Formulation and Background of the Study. The recent movement to the United States of displaced persons and refugees has aroused unusual interest, because of its dramatic character, the large numbers and different types of people involved and the international unrest characterizing the period when it occurred. People in America are interested in knowing the facts concerning these people, the non-governmental or private agencies that handled this problem; their resettlement, adjustment and assimilation into the United States and finally how this program worked and who made it work