Super-reflection of light from a random amplifying medium with disorder in the complex refractive index : Statistics of fluctuations

The probability distribution of the reflection coefficient for light reflected from a one-dimensional random amplifying medium with {\it cross-correlated} spatial disorder in the real and the imaginary parts of the refractive index is derived using the method of invariant imbedding. The statistics of fluctuations have been obtained for both the correlated telegraph noise and the Gaussian white-noise models for the disorder. In both cases, an enhanced backscattering (super-reflection with reflection coefficient greater than unity) results because of coherent feedback due to Anderson localization and coherent amplification in the medium. The results show that the effect of randomness in the imaginary part of the refractive index on localization and super-reflection is qualitatively different.Comment: RevTex 6 pages, 3 figures in ps file

Elevated levels of serum sialic acid and C-reactive protein: markers of systemic inflammation in patients with chronic obstructive pulmonary disease

Background: Chronic obstructive pulmonary disease (COPD) is a systemic chronic inflammatory disease with pulmonary and extra-pulmonary manifestations involving lungs causing airways dysfunction. C-reactive protein (C-RP) is a positive acute phase reactant and albumin a negative phase reactant during inflammation in COPD patients. Sialic acid (SA) prevalent in mucus rich tissues is gaining importance as biochemical marker in inflammatory immune response. Purpose of present study was to measure serum C-reactive protein (C-RP), total sialic acid and albumin levels in COPD patients and establish there association in COPD and compare with healthy controls.Methods: Seventy five clinically confirmed COPD patients, both male and female between the age group of 38-70 years were selected for the study and age/ sex matched healthy volunteers as controls were selected for comparison. Serum samples were analyzed for C-RP (mg/dl) by nephalometry and TSA (mmol/L) by periodate resorcinol method and albumin by dye binding method by spectrophotometer.Results: The mean value of serum C-RP in cases was 3.26±2.0 (mg/dl) and in controls 0.57±0.34 (mg/dl) with p<0.001. TSA in cases was 3.53±1.41 (mmol/L) compared to controls 1.81±0.53 (mmol/L), p<0.001. There was a statistically significant positive correlation between C-RP and TSA (r=0.755, p<0.001). The mean value of Albumin in cases decreased (2.54±0.87) as compared to control (4.07±0.66) (p<0.001) showed negative correlation with C-RP (r= -0.418, p<0.01) and TSA (r= -0.728, p<0.001). There was a significant decrease in BMI among cases 19.95±3.17 compared to control 21.17±1.78 p<0.001.Conclusions: C- reactive protein in association with TSA has increased in COPD as a marker of systemic inflammation. Albumin and BMI decreased as a result of nutritional depletion. Patients with low BMI and low serum albumin level have greater risk of having exacerbation, acute respiratory failure than patients with normal BMI.

S-Adenosyl homocysteine and DNA ends stimulate promiscuous nuclease activities in the Type III restriction endonuclease EcoPI

In the absence of the methyl donor S-adenosyl methionine and under certain permissive reaction conditions, EcoPI shows non-specific endonuclease activity. We show here that the cofactor analogue S-adenosyl homocysteine promotes this promiscuous DNA cleavage. Additionally, an extensive exonuclease-like processing of the DNA is also observed that can even result in digestion of non-specific DNA in trans. We suggest a model for how DNA communication events initiating from non-specific sites, and in particular free DNA ends, could produce the observed cleavage patterns

A review on drug resistance patho-mechanisms in ESKAPE bacterial pathogens

The escalating incidence of nosocomial infections stemming from ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) bacterial pathogens presents a formidable clinical challenge globally, affecting both the developed and developing nations. These pathogens, which are distinguished by their robust antibiotic resistance mechanisms, pose a significant threat to the public health. Their ability to evade traditional antimicrobial treatments underscores the urgent need for novel therapeutic stratifies or alternative approaches to mitigate their negative impact. Understanding the intricate mechanisms underpinning antibacterial resistance in ESKAPE bacteria is paramount for developing effective interventions. Enhanced insights into these mechanisms will facilitate the prediction of resistance patterns among the multidrug-resistant pathogens, thereby guiding the development of targeted therapies and preventive measures. Consequently, comprehensive efforts are needed aiming at unraveling the intricacies of antibacterial resistance in ESKAPE pathogens that are imperative to safeguarding the public health. The aim of the present review was to highlight the patho-mechanisms of ESKAPE bacteria towards the different antibiotics and genes involved in multi-drug resistance

Comparative analysis of co-processed starches prepared by three different methods

Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that co-granulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of co-processing influences the powder and tableting properties of the co-processed excipient

Comparative analysis of co-processed starches prepared by three different methods

Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that co-granulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of co-processing influences the powder and tableting properties of the co-processed excipient

Reversible and repeatable phase transition at a negative temperature regime for doped and co-doped spin coated mixed valence vanadium oxide thin films

Smooth, uniform mixed valance vanadium oxide (VO) thin films are grown on flexible, transparent Kapton and opaque Al6061 substrates by the spin coating technique at a constant rpm of 3000. Various elements e.g., F, Ti, Mo and W are utilized for doping and co-doping of VO. All the spin coated films are heat treated in a vacuum. Other than the doping elements the existence of only V4+ and V5+ species is noticed in the present films. Transmittance as a function of wavelength and the optical band gap are also investigated for doped and co-doped VO thin films grown on a Kapton substrate. The highest transparency (approximate to 75%) is observed for the Ti, Mo and F (i.e., Ti-Mo-FVO) co-doped VO system while the lowest transparency (approximate to 35%) is observed for the F (i.e., FVO) doped VO system. Thus, the highest optical band gap is estimated as 2.73 eV for Ti-Mo-FVO and the lowest optical band gap (i.e., 2.59 eV) is found for the FVO system. The temperature dependent phase transition characteristics of doped and co-doped VO films on both Kapton and Al6061 are studied by the differential scanning calorimetry (DSC) technique. Reversible and repeatable phase transition is noticed in the range of -24 to -26.3 degrees C

Physiological Correlates of Volunteering

We review research on physiological correlates of volunteering, a neglected but promising research field. Some of these correlates seem to be causal factors influencing volunteering. Volunteers tend to have better physical health, both self-reported and expert-assessed, better mental health, and perform better on cognitive tasks. Research thus far has rarely examined neurological, neurochemical, hormonal, and genetic correlates of volunteering to any significant extent, especially controlling for other factors as potential confounds. Evolutionary theory and behavioral genetic research suggest the importance of such physiological factors in humans. Basically, many aspects of social relationships and social activities have effects on health (e.g., Newman and Roberts 2013; Uchino 2004), as the widely used biopsychosocial (BPS) model suggests (Institute of Medicine 2001). Studies of formal volunteering (FV), charitable giving, and altruistic behavior suggest that physiological characteristics are related to volunteering, including specific genes (such as oxytocin receptor [OXTR] genes, Arginine vasopressin receptor [AVPR] genes, dopamine D4 receptor [DRD4] genes, and 5-HTTLPR). We recommend that future research on physiological factors be extended to non-Western populations, focusing specifically on volunteering, and differentiating between different forms and types of volunteering and civic participation

Prognosticfactors in patients with renal cell carcinoma: Is TNM (1997) staging relevant in Indian subpopulation?

BACKGROUND: RCC (Renal Cell Carcinoma) is a common genitourinary malignancy, but its behavior has not been studied in the Indian Subpopulation. AIMS: The aim of this study was to assess the validity of 1997 AJCC TNM staging in Indian subpopulation and also to identify independent predictors for survival in patients having RCC. SETTING AND DESIGN: Retrospective uncontrolled analysis of patients with RCC was performed at our centre. MATERIAL AND METHODS: Medical records of patients of undergoing radical nephrectomy at our center between 1994 to August 2003 were identified retrospectively. Medical records of 178 patients were available for analysis. Patient characteristics, preoperative imaging and surgical details were reviewed. Each tumor was staged according to the 1997 AJCC TNM classification. Nuclear grade was assigned according to the Fuhrman\u2032s grading system. STATISTICAL METHODS: Statistical analysis was performed using statistical software and descriptive statistics and survival functions were obtained. Univariate and multivariate analysis of factors affecting outcome of the patient were performed. RESULTS: Mean follow up period was 42.3 months (range 3 to 108 months). Stage wise 5-year Cancer specific survival was 87.2% in stage 1 disease, 74.3% in stage 2, 36.4% in stage 3 and 3.1% in stage 4. Univariate analysis revealed that stage, grade and lymph node status were statistically significant (P=0.009, 0.007 and 0.003 respectively). Sub-classifying stage 1 tumors between tumor of less than 4 cm. and more than 4 cm. did not reveal any statistically significant difference in survival (P=0.32). Multivariate analysis model revealed that Fuhrman\u2032s grade and lymph node status were statistically significant (P=0.007 and 0.002 respectively). CONCLUSION: This study validates the TNM (1997) staging for RCC as having significant survival impact in the Indian subpopulation. Sub-classifying stage 1 tumors between tumor of less than 4 cm. and more than 4 cm is not of much importance. Nuclear grade and lymph node involvement are important independent predictors of survival. Organ confined tumors with high nuclear grades need to be followed up more rigorously

Calibration of VELC detectors on-board Aditya-L1 mission

Aditya-L1 is the first Indian space mission to explore the Sun and solar atmosphere with seven multi-wavelength payloads, with Visible Emission Line Coronagraph (VELC) being the prime payload. It is an internally occulted coronagraph with four channels to image the Sun at 5000 \AA~ in the field of view 1.05 - 3 \rsun, and to pursue spectroscopy at 5303 \AA, 7892 \AA~ and 10747 \AA~ channels in the FOV (1.05 - 1.5 \rsun). In addition, spectropolarimetry is planned at 10747 \AA~ channel. Therefore, VELC has three sCMOS detectors and one InGaAs detector. In this article, we aim to describe the technical details and specifications of the detectors achieved by way of thermo-vacuum calibration at the CREST campus of the Indian Institute of Astrophysics, Bangalore, India. Furthermore, we report the estimated conversion gain, full-well capacity, and readout noise at different temperatures. Based on the numbers, it is thus concluded that it is essential to operate the sCMOS detectors and InGaAs detectors at $-5^{\circ}$ and $-17^{\circ}$ C, respectively, at the spacecraft level.Comment: Accepted for publication in Experimental Astronomy; 13 Pages, 5 Figures and 8 Table