The Frequency and Natural History of Urinary Tract Infection in School Children

This presentation reviews briefly investigations of the epidemiology and natural history of urinary tract infections in school children conducted during the past four years in Central Virginia. The results of this work will be summarized and their implications discussed

Solitary and compact-like shear waves in the bulk of solids

We show that a model proposed by Rubin, Rosenau, and Gottlieb [J. Appl. Phys. 77 (1995) 4054], for dispersion caused by an inherent material characteristic length, belongs to the class of simple materials. Therefore, it is possible to generalize the idea of Rubin, Rosenau, and Gottlieb to include a wide range of material models, from nonlinear elasticity to turbulence. Using this insight, we are able to fine-tune nonlinear and dispersive effects in the theory of nonlinear elasticity in order to generate pulse solitary waves and also bulk travelling waves with compact support

The surface climatology of the eastern Mediterranean region obtained in a three-member ensemble climate change simulation experiment

International audienceTwo configurations of RegCM3 regional climate model (RCM) have been used to downscale results of two atmosphere-ocean global climate model (AOGCM) simulations of the current (1961?1990) and future climates (2071?2100) over the eastern Mediterranean (EM) region. The RCM domain covering the EM region from northern Africa to central part of Asia Minor with grid spacing of 50 km was used. Three sets of RCM simulations were completed. Results of the RCM experiment support earlier projections of a temperature (annual precipitation) increase (decrease) to the end of 21st century over the EM. The roles of several major factors in controlling uncertainty of the climate change estimates are evaluated. The main uncertainty factors appear to be associated with possible inadequacies in RCM description of the EM-climate-controlling developments over remotely located areas as well as those in the simulations of the global climate and its trends by the AOGCMs

The effect of environmental stochasticity on species richness in neutral communities

Environmental stochasticity is known to be a destabilizing factor, increasing abundance fluctuations and extinction rates of populations. However, the stability of a community may benefit from the differential response of species to environmental variations due to the storage effect. This paper provides a systematic and comprehensive discussion of these two contradicting tendencies, using the metacommunity version of the recently proposed time-average neutral model of biodiversity which incorporates environmental stochasticity and demographic noise and allows for extinction and speciation. We show that the incorporation of demographic noise into the model is essential to its applicability, yielding realistic behavior of the system when fitness variations are relatively weak. The dependence of species richness on the strength of environmental stochasticity changes sign when the correlation time of the environmental variations increases. This transition marks the point at which the storage effect no longer succeeds in stabilizing the community

Pilot study of the safety and effect of adalimumab on pain, physical function, and musculoskeletal disease in mucopolysaccharidosis types I and II.

Mucopolysaccharidosis I and II are lysosomal storage disorders that, despite treatment with hematopoietic cell transplantation (HCT) and/or enzyme replacement therapy (ERT), continue to cause significant skeletal abnormalities leading to pain, stiffness, physical dysfunction, and short stature. Tumor necrosis factor - alpha (TNF-α) is elevated in individuals with MPS I and II and associated with pain and physical dysfunction. Therefore, we evaluated the safety and effects of the TNF-α inhibitor adalimumab in patients with MPS I and II in a 32-week, randomized, double blind, placebo-controlled, crossover study of adalimumab at a dose of 20 mg (weight 15-<30 kg) or 40 mg (weight ≥ 30 kg) administered subcutaneously every other week or saline placebo for 16 weeks. Participants were evaluated at baseline, week 16, and week 32 with the Children's Health Questionnaire - Parent Form 50 (CHQ-PF50), the Pediatric Pain Questionnaire (PPQ), range-of-motion (ROM) measurements, anthropometry, six-minute walk test (6MWT), hand dynamometer, and laboratory evaluations for safety. The primary outcome was safety and primary efficacy outcome was bodily pain (BP) measured by the CHQ-PF50. Two subjects, one with MPS I and one with MPS II, completed the study. Adalimumab was well tolerated and there were no serious adverse events. Standardized BP scores for age and gender were higher (i.e. less pain) at the end of the treatment versus placebo phase for both subjects. Subject #1 became unblinded during treatment due to skin erythema. Behavior measured by both CHQ-PF50 and parental report improved during treatment compared to placebo in both subjects. ROM improved by > 5° in seven of eight joints in Subject #1 and five of eight joints in Subject #2 (range 7.0° to 52.8°). There was no change in the PPQ, 6MWT, or hand dynamometer. Data from this small pilot study suggest that treatment with adalimumab is safe, tolerable, and may improve ROM, physical function, and possibly pain, in children with MPS I or II. However, additional clinical trials are needed before this therapy should be recommended as part of clinical care

The Cauchy Problem for a One Dimensional Nonlinear Peridynamic Model

This paper studies the Cauchy problem for a one-dimensional nonlinear peridynamic model describing the dynamic response of an infinitely long elastic bar. The issues of local well-posedness and smoothness of the solutions are discussed. The existence of a global solution is proved first in the sublinear case and then for nonlinearities of degree at most three. The conditions for finite-time blow-up of solutions are established.Comment: To appear in Journal of Differential Equations (added references, corrected typos, minor revision in Section 2, 18 pages