The impact of peppermint oil on the irritable bowel syndrome: A meta-analysis of the pooled clinical data 11 Medical and Health Sciences 1103 Clinical Sciences

Background: Peppermint oil (PO) has intrinsic properties that may benefit patients with irritable bowel syndrome (IBS) symptoms. The study objective was to determine the effect of peppermint oil in the treatment of the IBS. Methods: We systematically searched MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (Cochrane CENTRAL), ClinicalTrials.gov, EMBASE (Ovid), and Web of Science for randomized controlled trials (RCTs) of PO for IBS. We appraised the eligible studies by the Cochrane risk of bias tool. We performed random-effects meta-analysis on primary outcomes including global improvement in IBS symptoms and abdominal pain. A PRISMA-compliant study protocol is registered in PROSPERO Register [2016, CRD42016050917]. Results: Twelve randomized trials with 835 patients were included. For global symptom improvement, the risk ratio (RR) from seven RCTs for the effect of PO (n = 253) versus placebo (n = 254) on global symptoms was 2.39 [95% confidence interval (CI): 1.93, 2.97], I = 0%, z = 7.93 (p < 0.00001). Regarding abdominal pain, the RR from six RCTs for the effect of PO (n = 278) versus placebo (n = 278) was 1.78 [95% CI: 1.43, 2.20], I = 0%, z = 5.23 (p < 0.00001). Overall, there were no differences in the reported adverse effects: PO (32 events, 344 total, 9.3%) versus placebo (20 events, 327 total, 6.1%) for eight RCTs; RR 1.40 [95% CI: 0.87, 2.26] I = 0%, z = 1.39 (p = 0.16). The number needed to treat with PO to prevent one patient from having persistent symptoms was three for global symptoms and four for abdominal pain. Conclusions: In the most comprehensive meta-analysis to date, PO was shown to be a safe and effective therapy for pain and global symptoms in adults with IBS

Rationally designed rare earth separation by selective oxalate solubilization

A simple, environmentally benign, and efficient chemical separation of rare earth oxalates (CSEREOX) within two rare earth element (REE) subgroups has been developed. The protocol allows for selective solubilization of water-insoluble oxalates of rare earth elements, and results in efficient REE extraction even at low initial concentrations (&lt;5%) from processed magnet wastes.</p

Additional file 2: of The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data

Table of Excluded Studies. Ten of twenty-two included randomized controlled trials (RCTs) were eliminated for reasons shown. Five studies for data that was shown in other publications, four RCTs were cross-over trials without sufficient washout period, and an RCT was permitted rescue medication without sufficient data to permit analysis. (PDF 369 kb

Rationally designed rare earth separation by selective oxalate solubilization

A simple, eco-friendly and efficient chemical separation of rare earth oxalates (CSEREOX) in water within two rare earth metals subgroups has been elaborated.</p

Additional file 1: of The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data

Table of Medical Literature Search Results for Randomized Controlled Trials of Enteric-Coated Peppermint Oil for the Irritable Bowel Syndrome. We searched the medical literature for randomized controlled trials of enteric-coated peppermint oil for the treatment of the irritable bowel syndrome. Our search methodology yielded 102 reports in PubMed, 396 in Embase, 201 in Web of Science, and 60 in the Cochrane library. (PDF 265 kb

Investigation of the hydrodynamic behaviour of particles and aggregates by particle image velocimetry (PIV)

The IWA International Conference on Particle Separation (PS2007), Toulouse, France, 9-12 July 2007