Lomustine use in combination with etoposide, cytarabine and melphalan in a brief conditioning regimen for auto-HSCT in patients with lymphoma: the optimal dose

Univ Fed Juiz de Fora, Div Hematol & Bone Marrow Transplantat, Juiz de Fora, MG, BrazilMed Univ S Carolina, Div Hematol Oncol, Charleston, SC 29425 USAUniv Fed Juiz de Fora, Div Clin Med, Juiz de Fora, MG, BrazilUniversidade Federal de São Paulo, Div Hematol, São Paulo, BrazilUniversidade Federal de São Paulo, Div Hematol, São Paulo, BrazilWeb of Scienc

How reproducible is the acoustical characterization of porous media?

There is a considerable number of research publications on the characterization of porous media that is carried out in accordance with ISO 10534-2 (International Standards Organization, Geneva, Switzerland, 2001) and/or ISO 9053 (International Standards Organization, Geneva, Switzerland, 1991). According to the Web of Science(TM) (last accessed 22 September 2016) there were 339 publications in the Journal of the Acoustical Society of America alone which deal with the acoustics of porous media. However, the reproducibility of these characterization procedures is not well understood. This paper deals with the reproducibility of some standard characterization procedures for acoustic porous materials. The paper is an extension of the work published by Horoshenkov, Khan, Bécot, Jaouen, Sgard, Renault, Amirouche, Pompoli, Prodi, Bonfiglio, Pispola, Asdrubali, Hübelt, Atalla, Amédin, Lauriks, and Boeckx [J. Acoust. Soc. Am. 122(1), 345-353 (2007)]. In this paper, independent laboratory measurements were performed on the same material specimens so that the naturally occurring inhomogeneity in materials was controlled. It also presented the reproducibility data for the characteristic impedance, complex wavenumber, and for some related pore structure properties. This work can be helpful to better understand the tolerances of these material characterization procedures so improvements can be developed to reduce experimental errors and improve the reproducibility between laboratories

Modeling of negative Poisson’s ratio (auxetic) crystalline cellulose Iβ

Energy minimizations for unstretched and stretched cellulose models using an all-atom empirical force field (Molecular Mechanics) have been performed to investigate the mechanism for auxetic (negative Poisson’s ratio) response in crystalline cellulose Iβ from kraft cooked Norway spruce. An initial investigation to identify an appropriate force field led to a study of the structure and elastic constants from models employing the CVFF force field. Negative values of on-axis Poisson’s ratios nu31 and nu13 in the x1-x3 plane containing the chain direction (x3) were realized in energy minimizations employing a stress perpendicular to the hydrogen-bonded cellobiose sheets to simulate swelling in this direction due to the kraft cooking process. Energy minimizations of structural evolution due to stretching along the x3 chain direction of the ‘swollen’ (kraft cooked) model identified chain rotation about the chain axis combined with inextensible secondary bonds as the most likely mechanism for auxetic response

«LIFE QUALITY» INDICATORS IN PATIENTS WITH CHRONIC DERMATOSIS

The subject of the study – the analysis of «life quality» indicators in patients with chronic dermatosis. The purpose of a work is to compare «life quality» indicators in patients with rosacea and psoriasis with complicated and uncomplicated forms of the disease. The research is conducting with the WHOOOL-BREF Quiz – an analysis of four basic spheres, characterizing different aspects of life quality indicators of patients with rosacea and psoriasis testifies to reliable differences of the majority of scores in examined patients, comparing with average scores in «healthy people»; more pronounced differences were mentioned in complicated forms of these and others dermatosis.Keywords : rosacea, psoriasis, demodecosis, arthropathia, life quality.  Предмет исследования – анализ показателей качества жизни у больных хроническими дерматозами. Цель работы – сравнить показатели качества жизни больных розацеа и псориазом с осложненными и не осложненными формами течения заболевания. Проведение с помощью опросника ВОЗ (WHOOOL-BREF) – анализа 4 основных сфер, характеризующих различные аспекты качества жизни больных розацеа и псориазом свидетельствует о достоверных отличиях по большинству изученных показателей у обследованных больных по сравнению со среднестатистическими коэффициентами у «здоровых лиц»; более выраженные отличия наблюдались при осложненных формах этих и других дерматозов.Ключевые слова: розацеа, псориаз, демодекоз, артропатия, качество жизни

Promoting successful participation of people living with Alzheimer's disease and related dementias in pain-related neuroimaging research studies

Recruitment and retention of participants for pain-related neuroimaging research is challenging and becomes increasingly so when research participants have a diagnosis of Alzheimer's disease and related dementias (ADRD). This article shares the authors' recommendations from several years of successful recruitment and completion of pain-related neuroimaging studies of people living with ADRD and includes supportive literature. While not an exhaustive list, this review covers several topics related to recruitment and retention of participants living with ADRD, including community engagement, capacity to consent, dementia diagnostic criteria, pain medication and other study exclusion criteria, participant and caregiver burden, communication concerns, and relationships with neuroimaging facilities. Threaded throughout the paper are important cultural considerations. Additionally, we discuss implications of the coronavirus (COVID-19) pandemic for recruitment. Once tailored to specific research study protocols, these proven strategies may assist researchers with successfully recruiting and retaining participants living with ADRD for pain-related neuroimaging research studies toward improving overall health outcomes

Dramatic Shifts in Benthic Microbial Eukaryote Communities following the Deepwater Horizon Oil Spill

Benthic habitats harbour a significant (yet unexplored) diversity of microscopic eukaryote taxa, including metazoan phyla, protists, algae and fungi. These groups are thought to underpin ecosystem functioning across diverse marine environments. Coastal marine habitats in the Gulf of Mexico experienced visible, heavy impacts following the Deepwater Horizon oil spill in 2010, yet our scant knowledge of prior eukaryotic biodiversity has precluded a thorough assessment of this disturbance. Using a marker gene and morphological approach, we present an intensive evaluation of microbial eukaryote communities prior to and following oiling around heavily impacted shorelines. Our results show significant changes in community structure, with pre-spill assemblages of diverse Metazoa giving way to dominant fungal communities in post-spill sediments. Post-spill fungal taxa exhibit low richness and are characterized by an abundance of known hydrocarbon-degrading genera, compared to prior communities that contained smaller and more diverse fungal assemblages. Comparative taxonomic data from nematodes further suggests drastic impacts; while pre-spill samples exhibit high richness and evenness of genera, post-spill communities contain mainly predatory and scavenger taxa alongside an abundance of juveniles. Based on this community analysis, our data suggest considerable (hidden) initial impacts across Gulf beaches may be ongoing, despite the disappearance of visible surface oil in the region

Network Alterations in Comorbid Chronic Pain and Opioid Addiction: An Exploratory Approach

The comorbidity of chronic pain and opioid addiction is a serious problem that has been growing with the practice of prescribing opioids for chronic pain. Neuroimaging research has shown that chronic pain and opioid dependence both affect brain structure and function, but this is the first study to evaluate the neurophysiological alterations in patients with comorbid chronic pain and addiction. Eighteen participants with chronic low back pain and opioid addiction were compared with eighteen age- and sex-matched healthy individuals in a pain-induction fMRI task. Unified structural equation modeling (SEM) with Lagrange multiplier (LM) testing yielded a network model of pain processing for patient and control groups based on 19 a priori defined regions. Tests of differences between groups on specific regression parameters were determined on a path-by-path basis using z-tests corrected for the number of comparisons. Patients with the chronic pain and addiction comorbidity had increased connection strengths; many of these connections were interhemispheric and spanned regions involved in sensory, affective, and cognitive processes. The affected regions included those that are commonly altered in chronic pain or addiction alone, indicating that this comorbidity manifests with neurological symptoms of both disorders. Understanding the neural mechanisms involved in the comorbidity is crucial to finding a comprehensive treatment, rather than treating the symptoms individually