L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling.

During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits. How such a system works in coordination is not well understood. Cross-regulatory interactions between different signalling pathways and redundancy between them can increase precision and fidelity of guidance systems. Immunoglobulin superfamily proteins of the NCAM and L1 families couple specific substrate recognition and cell adhesion with the activation of receptor tyrosine kinases. Thus it has been shown that L1CAM-mediated cell adhesion promotes the activation of the EGFR (erbB1) from Drosophila to humans. Here we explore the specificity of the molecular interaction between L1CAM and the erbB receptor family. We show that L1CAM binds physically erbB receptors in both heterologous systems and the mammalian developing brain. Different Ig-like domains located in the extracellular part of L1CAM can support this interaction. Interestingly, binding of L1CAM to erbB enhances its response to neuregulins. During development this may synergize with the activation of erbB receptors through L1CAM homophilic interactions, conferring diffusible neuregulins specificity for cells or axons that interact with the substrate through L1CAM

Imaging the Ionized Disk of the High-Mass Protostar Orion-I

We have imaged the enigmatic radio source-I (Orion-I) in the Orion-KL nebula with the VLA at 43 GHz with 34 mas angular resolution. The continuum emission is highly elongated and is consistent with that expected from a nearly edge-on disk. The high brightness and lack of strong molecular lines from Orion-I can be used to argue against emission from dust. Collisional ionization and H-minus free-free opacity, as in Mira variables, require a central star with >10^5 Lsun, which is greater than infrared observations allow. However, if significant local heating associated with accretion occurs, lower total luminosities are possible. Alternatively, photo-ionization from an early B-type star and p+/e- bremsstrahlung can explain our observations, and Orion-I may be an example of ionized accretion disk surrounding a forming massive star. Such accretion disks may not be able to form planets efficiently.Comment: 16 pages, 1 table, 3 figure

Cicrumnuclear Supernova Remnants and HII Regions in NGC 253

Archival VLA data has been used to produce arcsecond-resolution 6- and 20-cm images of the region surrounding the nuclear 200-pc (~15") starburst in NGC 253. Twenty-two discrete sources stronger than 0.4 mJy have been detected within ~2 kpc (~3') of the galaxy nucleus; almost all these sources must be associated with the galaxy. None of the radio sources coincides with a detected X-ray binary, so they appear to be due to supernova remnants and H II regions. The region outside the central starburst has a derived radio supernova rate of <~0.1/yr, and may account for at least 20% of the recent star formation in NGC 253. Most of the newly identified sources have steep, nonthermal radio spectra, but several relatively strong thermal sources also exist, containing the equivalent of tens of O5 stars. These stars are spread over tens of parsecs, and are embedded in regions having average ionized gas densities of 20-200/cm^3, much lower than in the most active nuclear star-forming regions in NGC 253 or in the super star clusters seen in other galaxies. The strongest region of thermal emission coincides with a highly reddened area seen at near-infrared wavelengths, possibly containing optically obscured H II regions.Comment: 17 pages, 3 postscript figures, AASTeX format, in press for Astronomical Journal, July 200

Coaxial Jets and Sheaths in Wide-Angle-Tail Radio Galaxies

We add 20, 6 and 3.6 cm wavelength VLA observations of two WATs, 1231+674 and 1433+553, to existing VLA data at 6 and 20 cm, in order to study the variations of spectral index as a function of position. We apply the spectral tomography process that we introduced in our analysis of 3C67, 3C190 and 3C449. Both spectral tomography and polarization maps indicate that there are two distinct extended components in each source. As in the case of 3C449, we find that each source has a flat spectrum jet surrounded by a steeper spectrum sheath. The steep components tend to be more highly polarized than the flat components. We discuss a number of possibilities for the dynamics of the jet/sheath systems, and the evolution of their relativistic electron populations. While the exact nature of these two coaxial components is still uncertain, their existence requires new models of jets in FR I sources and may also have implications for the dichotomy between FR Is and FR IIs.Comment: 29 text pages plus 13 figures. Scheduled for publication in May 10, 1999 Ap

NICMOS and VLA Observations of the Gravitatonally Lensed Ultraluminous BAL Quasar APM~08279+5255: Detection of a Third Image

We present a suite of observations of the recently identified ultraluminous BAL quasar APM 08279+5255, taken both in the infra-red with the NICMOS high resolution camera on board the Hubble Space Telescope, and at 3.5cm with the Very Large Array. With an inferred luminosity of ~5x10^15 Solar luminosities, APM 08279+5255 is apparently the most luminous system known. Extant ground-based images show that APM 08279+5255 is not point-like, but is instead separated into two components, indicative of gravitational lensing. The much higher resolution images presented here also reveal two point sources, A and B, of almost equal brightness (f_B/f_A=0.782 +/- 0.010), separated by 0."378 +/- 0."001, as well as a third, previously unknown, fainter image, C, seen between the brighter images. While the nature of C is not fully determined, several lines of evidence point to it being a third gravitationally lensed image of the quasar, rather than being the lensing galaxy. Simple models which recover the relative image configuration and brightnesses are presented. While proving to be substantially amplified, APM 08279+5255 possesses an intrinsic bolometric luminosity of ~10^14 to 10^15 Solar luminosities and remains amongst the most luminous objects known.Comment: 21 pages, 5 figures (2 as GIF files); accepted for publication in the Astronomical Journa

A Compact Extreme Scattering Event Cloud Towards AO 0235+164

We present observations of a rare, rapid, high amplitude Extreme Scattering Event toward the compact BL-Lac AO 0235+164 at 6.65 GHz. The ESE cloud is compact; we estimate its diameter between 0.09 and 0.9 AU, and is at a distance of less than 3.6 kpc. Limits on the angular extent of the ESE cloud imply a minimum cloud electron density of ~ 4 x 10^3 cm^-3. Based on the amplitude and timescale of the ESE observed here, we suggest that at least one of the transients reported by Bower et al. (2007) may be attributed to ESEs.Comment: 11 pages, 2 figure

Rotation Measure Synthesis of Galactic Polarized Emission with the DRAO 26-m Telescope

Radio polarimetry at decimetre wavelengths is the principal source of information on the Galactic magnetic field. The diffuse polarized emission is strongly influenced by Faraday rotation in the magneto-ionic medium and rotation measure is the prime quantity of interest, implying that all Stokes parameters must be measured over wide frequency bands with many frequency channels. The DRAO 26-m Telescope has been equipped with a wideband feed, a polarization transducer to deliver both hands of circular polarization, and a receiver, all operating from 1277 to 1762 MHz. Half-power beamwidth is between 40 and 30 arcminutes. A digital FPGA spectrometer, based on commercially available components, produces all Stokes parameters in 2048 frequency channels over a 485-MHz bandwidth. Signals are digitized to 8 bits and a Fast Fourier Transform is applied to each data stream. Stokes parameters are then generated in each frequency channel. This instrument is in use at DRAO for a Northern sky polarization survey. Observations consist of scans up and down the Meridian at a drive rate of 0.9 degree per minute to give complete coverage of the sky between declinations -30 degree and 90 degree. This paper presents a complete description of the receiver and data acquisition system. Only a small fraction of the frequency band of operation is allocated for radio astronomy, and about 20 percent of the data are lost to interference. The first 8 percent of data from the survey are used for a proof-of-concept study, which has led to the first application of Rotation Measure Synthesis to the diffuse Galactic emission obtained with a single-antenna telescope. We find rotation measure values for the diffuse emission as high as approximately 100 rad per square metre, much higher than recorded in earlier work.Comment: Accepted for publication in The Astronomical Journa

Spin Dynamics of Cavity Polaritons

We have studied polariton spin dynamics in a GaAs/AlGaAs microcavity by means of polarization- and time-resolved photoluminescence spectroscopy as a function of excitation density and normal mode splitting. The experiments reveal a novel behavior of the degree of polarization of the emission, namely the existence of a finite delay to reach its maximum value. We have also found that the stimulated emission of the lower polariton branch has a strong influence on spin dynamics: in an interval of $\sim$150 ps the polarization changes from +100% to negative values as high as -60%. This strong modulation of the polarization and its high speed may open new possibilities for spin-based devices.Comment: 4 pages, 3 eps figures, RevTeX, Physical Review B Rapid (submitted

Nuclear gas dynamics in Arp 220 - sub-kiloparsec scale atomic hydrogen disks

We present new, high angular resolution (~0.22") MERLIN observations of neutral hydrogen (HI) absorption and 21-cm radio continuum emission across the central ~900 parsecs of the ultraluminous infrared galaxy, Arp220. Spatially resolved HI absorption is detected against the morphologically complex and extended 21-cm radio continuum emission, consistent with two counterrotating disks of neutral hydrogen, with a small bridge of gas connecting the two. We propose a merger model in which the two nuclei represent the galaxy cores which have survived the initial encounter and are now in the final stages of merging, similar to conclusions drawn from previous CO studies (Sakamoto, Scoville & Yun 1999). However, we suggest that instead of being coplanar with the main CO disk (in which the eastern nucleus is embedded), the western nucleus lies above it and, as suggested by bridge of HI connecting the two nuclei, will soon complete its final merger with the main disk. We suggest that the collection of radio supernovae (RSN) detected in VLBA studies in the more compact western nucleus represent the second burst of star formation associated with this final merger stage and that free-free absorption due to ionised gas in the bulge-like component can account for the observed RSN distribution. (Abridged)Comment: 26 pages including 8 figures and 1 table; accepted for publication in Ap

Interaction and dynamical binding of spin waves or excitons in quantum Hall systems

Interaction between spin waves (or excitons) moving in the lowest Landau level is studied using numerical diagonalization. Becuse of complicated statistics obeyed by these composite particles, their effective interaction is completely different from the dipole-dipole interaction predicted in the model of independent (bosonic) waves. In particular, spin waves moving in the same direction attract one another which leads to their dynamical binding. The interaction pseudopotentials V_[up,up](k) and V_[up,down](k) for two spin waves with equal wavevectors k and moving in the same or opposite directions have been calculated and shown to obey power laws V(k) ~ k^alpha at small k. A high value of alpha_[up,up]~4 explains the occurrence of linear bands in the spin excitation spectra of quantum Hall droplets.Comment: 6 pages, 4 figures, submitted to PR